Compare and book 5 Star hotels in Big Pine Key, Florida

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Check availability on Big Pine Key 5 Star Hotels

Tonight
5 Jul - 6 Jul
Tomorrow
6 Jul - 7 Jul
Next weekend
11 Jul - 13 Jul
In two weeks
18 Jul - 20 Jul

Top Big Pine Key 5 Star Hotels

Isla Bella Beach Resort & Spa
Property grounds

Isla Bella Beach Resort & Spa

5.0 star property
9.0 out of 10, Wonderful, (1006)
"Had a great stay"
The price is £276
includes taxes & fees
3 Aug - 4 Aug
Isla Bella Beach Resort & Spa
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Explore similar 4-star hotels

Many 4-star hotels have the same amenities as 5-star hotels. See all 4-star hotels in Big Pine Key.
Tranquility Bay Beachfront Hotel and Resort

Tranquility Bay Beachfront Hotel and Resort

2600 Overseas Hwy, Marathon, FL
The price is £248 per night from 6 Jul to 7 Jul
£248
6 Jul - 7 Jul
includes taxes & fees
8.8/10 Excellent! (1,001 reviews)
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Lowest nightly price found within the past 24 hours based on a 1 night stay for 2 adults. Prices and availability subject to change. Additional terms may apply.

Learn more about Big Pine Key

Snorkel crystal-clear waters teeming with colourful fish, then spot adorable Key deer at the National Key Deer Refuge. Unwind on pristine beaches like Calusa or Sandspur, where soft sand meets turquoise waves.

See all hotels in Big Pine Key
Big Pine Key showing a bay or harbour, a coastal town and general coastal views

Frequently asked questions

How much does it cost to stay in a 5-star hotel in Big Pine Key?
How much you pay for a 5-star hotel in Big Pine Key depends on factors like when you want to go and the length of your escape. An insider tip for bagging an awesome deal? Use our pricing filters to compare the available options for your preferred dates.

  • Search for the lowest price per night from £160

What makes a hotel 5 stars in Big Pine Key?
From fine dining venues and 24/7 fitness centres to pools and luxury bedding, the 5-star experience in Big Pine Key is all about luxury and relaxation. But it takes more than just top-notch amenities to get a 5-star rating. Accommodation also have to offer extraordinary guest-centric services like in-room beauty treatments, laundry and dry cleaning and a nightly turn-down service.
Are there any 5-star all-inclusive resorts in Big Pine Key?
Use our handy filters to find a luxury escape in Big Pine Key where most of what you need is included in the price. After your initial search, refine your results for accommodation that have a 5-star rating and are categorised as "All inclusive." The first thing on the schedule at these stays? Pure relaxation and indulgence.