Compare and book 5 Star hotels in Big Pine Key, Florida

    price find illustration

    Change your mind

    Book hotels with free cancellation
    deals illustration

    Treat yourself

    Save instantly and earn perks with One Key
    Learn about One Key
    bed illustration

    Be picky

    Search almost a million properties worldwide

Check availability on Big Pine Key 5 Star Hotels

Top Big Pine Key 5 Star Hotels

Our top choices for Big Pine Key 5-star hotels

Isla Bella Beach Resort & Spa
Property grounds

Isla Bella Beach Resort & Spa

5.0 star property
9.2 out of 10, Wonderful, (1033)
"Beautiful hotel with fantastic facilities and stunning views. Great spot for some family downtime - the kids loved the pools and the linked fishing charters were awesome "
The price is £238
includes taxes & fees
11 Sept - 12 Sept
Isla Bella Beach Resort & Spa
Save an average of 15% on thousands of hotels when you're signed in
Sign in
Sign up, it's free

Explore similar 4-star hotels

Many 4-star hotels have the same amenities as 5-star hotels. See all 4-star hotels in Big Pine Key.
Faro Blanco Resort & Yacht Club Marathon, Curio by Hilton

Faro Blanco Resort & Yacht Club Marathon, Curio by Hilton

1996 Overseas Highway, Marathon, FL
The price is £156 per night from 8 Sept to 9 Sept
£156
8 Sept - 9 Sept
includes taxes & fees
8.8/10 Excellent! (1,286 reviews)
Still don't see what you're looking for?
See all properties in Big Pine Key.
You can also use these popular filters to refine your search.
PoolSpaHot tubBreakfast includedWaterpark
Lowest nightly price found within the past 24 hours based on a 1 night stay for 2 adults. Prices and availability subject to change. Additional terms may apply.

Learn more about Big Pine Key

Explore romantic Big Pine Key: its fishing, beaches, natural setting and more!

See all hotels in Big Pine Key
Big Pine Key showing a bay or harbour, a coastal town and general coastal views

Top Big Pine Key Hotel Reviews

Isla Bella Beach Resort & Spa

Isla Bella Beach Resort & Spa

10/10 Excellent
"Beautiful hotel with fantastic facilities and stunning views. Great spot for some family downtime - the kids loved the pools and the linked fishing charters were awesome "
Matthew 5-night trip
Posted 2 days ago
Isla Bella Beach Resort & Spa

Frequently asked questions

How much does it cost to stay in a 5-star hotel in Big Pine Key?
How much you pay for a 5-star hotel in Big Pine Key depends on factors like when you want to go and the length of your escape. An insider tip for bagging an awesome deal? Use our pricing filters to compare the available options for your preferred dates.

  • Search for the lowest price per night from £156

What makes a hotel 5 stars in Big Pine Key?
From fine dining venues and 24/7 fitness centres to pools and luxury bedding, the 5-star experience in Big Pine Key is all about luxury and relaxation. But it takes more than just top-notch amenities to get a 5-star rating. Accommodation also have to offer extraordinary guest-centric services like in-room beauty treatments, laundry and dry cleaning and a nightly turn-down service.
Are there any 5-star all-inclusive resorts in Big Pine Key?
Use our handy filters to find a luxury escape in Big Pine Key where most of what you need is included in the price. After your initial search, refine your results for accommodation that have a 5-star rating and are categorised as "All inclusive." The first thing on the schedule at these stays? Pure relaxation and indulgence.