All Hotels by Independent in Santee - 2026 Updated Prices

Santee River Dam on Lake Marion, South Carolina, Aerial drone view of electric power lines

Change your mind
Book hotels with free cancellation
Treat yourself
Save instantly and earn perks with One Key
Learn about One Key
Be picky
Search almost a million properties worldwide

Check prices for these dates

Tonight

Tomorrow

This weekend

Next weekend

Save an average of 15% on thousands of hotels when you're signed in

Sign in

Sign up, it's free

Top Santee Hotel Reviews

Hampton Inn Santee-I-95

10/10 Excellent

"Nice breakfast, rooms spacious, convenient location"

Waterfront Lake Marion Retreat • Pool • Gazebo • Minutes from I-95

10/10 Excellent

"We felt at home from the moment we arrived until we left. Beautiful view of the lake from both sitting room and bedroom. The listing gives the impression (to me) it was a stand alone , but it is a condo / townhouse in a condo community. It was VERY quiet. We loved it and look forward to returning in the future."

Quality Inn & Suites Santee I-95

4/10 Poor

"The towels had dirt stains on them, there was hair everywhere in the bathroom, stuck to shower walls, on floor, etc…The guy that checked me in wasn’t helpful and had an attitude. It looked like dried blood on the stairwell, which was nasty, dirty. I won’t be back, too many better choices less than a mile away."

Explore a world of travel with Expedia

More ways to book

Book Independent in Santee on Expedia.com

Room 1

Change your mind

Treat yourself

Be picky

Check prices for these dates

Top Santee Hotel Reviews

Hampton Inn Santee-I-95

Tru By Hilton Santee

Best Western Plus Santee Inn

Baymont by Wyndham Santee

Fairfield Inn & Suites by Marriott Santee

Super 8 by Wyndham Santee/I-95

Waterfront Lake Marion Retreat • Pool • Gazebo • Minutes from I-95

Quality Inn & Suites Santee I-95

Comfort Inn & Suites Santee

Explore a world of travel with Expedia

Search Hotels by Independent in Santee

Change your mind

Treat yourself

Be picky

Check prices for these dates

Top Santee Hotel Reviews

Hampton Inn Santee-I-95

Explore a world of travel with Expedia