Santa Ana Holidays

Book a Hotel + Flight or Car together to unlock savings

Photo by Isa
    Plan, book, travel with confidence
    payments icon
    Better together
    Save up to £195 when you book a flight and hotel together*
    lob hotels icon
    Find the right fit
    With over 300,000 hotels worldwide, it's easy to create a perfect package
    lob packages icon
    Rest easy
    Packages with flights are ATOL protected

Your Santa Ana Holiday

Experience the energy and excitement of Santa Ana with a tailor-made Santa Ana holiday package. From its sunny weather to its diversity, you'll never have a dull moment in this city. You'll want to go sightseeing during your trip to Santa Ana. Swing by major attractions such as Bridge of the Americas, Miraflores Locks and Metropolitan Cathedral of Panama. Check out Expedia's wide range of travel options and start organising your ideal holiday to Santa Ana now.

Where to stay in Santa Ana

Find the best Santa Ana areas and neighborhoods for the activities you enjoy most. Learn more about Santa Ana
Default Image

Casco Viejo

3.5/5(3 area reviews)

Unique features of Casco Viejo include the historical sites and bars. Make a stop by Metropolitan Cathedral of Panama or National Theater while you're exploring the area.

Find hotels in Casco Viejo

Top hotels in Santa Ana

Hotel Riu Plaza Panama
Hotel Riu Plaza Panama
5 out of 5
Calle 50, Urb. Marbella, Panama City, Panama
Fully refundableReserve now, pay when you stay
The price is £89 per night from 25 Jun to 26 Jun
£89
per night
25 Jun - 26 Jun
9/10 Wonderful! (2,568 reviews)
"The rooms are very nice"

Reviewed on 18 Jun 2024

Hotel Riu Plaza Panama
Dreams Playa Bonita Panama - All Inclusive
Dreams Playa Bonita Panama - All Inclusive
4 out of 5
KM 7, Road to Veracruz, Veracruz, Panama
Fully refundableReserve now, pay when you stay
The price is £196 per night from 8 Jul to 9 Jul
£196
per night
8 Jul - 9 Jul
7.4/10 Good! (1,008 reviews)
"Good"

Reviewed on 12 Jun 2024

Dreams Playa Bonita Panama - All Inclusive
Megapolis Hotel Panamá
Megapolis Hotel Panamá
4.5 out of 5
Avenida Balboa, Panama City
Fully refundableReserve now, pay when you stay
The price is £110 per night from 20 Jun to 21 Jun
£110
per night
20 Jun - 21 Jun
8.2/10 Very Good! (446 reviews)
"Customer service"

Reviewed on 16 Jun 2024

Megapolis Hotel Panamá
See all 1,305 properties in Santa Ana
Lowest nightly price found within the past 24 hours based on a 1 night stay for 2 adults. Prices and availability subject to change. Additional terms may apply.

All Inclusive Holidays

All Inclusive Holidays

Beach Holidays

Beach Holidays

Family Friendly Holidays

Family Friendly Holidays

Frequently asked questions

How much does a Santa Ana travel package cost?
Starting from as low as , a package is your passport to low-cost travel. Build your own Santa Ana escape by picking from our great range of hotels, flights and rental cars.
If I'm not able to travel, can I cancel my Santa Ana travel package?
It is possible to cancel your Santa Ana booking if your plans have been upended. Whether you’ll incur a fee or not depends on your airline, hotel or car rental company. You may be able to change or cancel free of charge if you booked in the last 24 hours. Head to our Customer Service Portal to find out more.
How do I get a cheap travel package to Santa Ana?
Bundle your hotels and flights, add extras such as activities or a rental car, and save with a Santa Ana travel package. You won’t just score exciting discounts on your escape — you’ll have lots of choice too. When you book with Expedia, you can choose from more than 550 airlines and 1,000,000 hotels across the globe. Your affordable holiday starts right here, right now!
Does Expedia offer Book Now, Pay Later Santa Ana holidays?
Yes. Expedia has partnered with online lender Klarna to help you easily pay for your holiday in instalments. Simply select the payment plan best suited to your needs during the checkout process and take the stress out of budgeting for your next trip. Be sure to bundle your flights, hotel and car hire with Expedia to get the biggest bang for your holiday buck. Check out our flexible payment options below:

  • Pay monthly holidays: Realise your holiday dreams sooner with Klarna’s monthly instalment plans. If paying a little each month works for you, choose this option during the checkout process.
  • Pay in instalments holidays: Into the idea of paying down your holiday in multiple transactions? Then go for this Book Now, Pay Later option from Klarna.
  • Low deposit holidays: Hitting the “book now” button is much easier with this payment plan. Put down a small deposit on your escape and then start working on your travel itinerary.

Where should I stay in Santa Ana?
Urban explorers come from all corners of the globe to see Metropolitan Cathedral of Panama and Miraflores Locks in Santa Ana. Book yourself a room within a stone’s throw of these popular attractions and visit them whenever you want.
What are the top hotels in Santa Ana?
Get your trip off to a good start by booking a room at The Executive Hotel. It’s one of most sought-after hotels in Santa Ana. Another comfortable option is JW Marriott Panama.
How far in advance should I book my Santa Ana holiday?
Search Expedia to compare international flights ASAP. In most cases, you can purchase a ticket up to a year prior to departure. If it’s too early for your preferred air carrier, or you’ve left things to the last minute, fear not. Low prices to Santa Ana occasionally appear within weeks of the date of departure.
What does an Expedia Santa Ana travel package include?
Hotels, flights and a reliable car for all your fun road trip adventures. Simply choose your preferred bundle and gain access to great discounts. Once you’ve made your booking, add on some sightseeing tours and watch your savings grow. When it comes to crafting your Santa Ana escape, you’re in control!
What should I know before booking a Santa Ana travel package?
A travel package can be tailored to your budget and is a simple way to make your budget go further. How little or much you include is up to you. Rental cars, hotels and flights — decide on a combination that suits your plans.
Can I choose my airline with a Santa Ana Expedia travel package?
With a travel package, you’re the one in charge. Whether you’d like to fly to Santa Ana in economy or first class, simply pick from the available airline options. Expedia has access to over 550 airline partners across the world.

Popular places to visit

Image for Multiplaza Pacific Mall

Multiplaza Pacific Mall

4.5/5(8 reviews)

During your trip to Panama City, you can search for that perfect souvenir at Multiplaza Pacific Mall. You can enjoy the restaurants while in the area.

Multiplaza Pacific Mall
Image for Cinta Costera

Cinta Costera

4/5(5 reviews)

Explore the great outdoors at Cinta Costera, a lovely green space in Panama City. While you're in the area, stroll along the seaside.

Cinta Costera
Image for Avenida Balboa

Avenida Balboa

3.5/5(9 reviews)

You can browse for the perfect souvenirs at Avenida Balboa during your stay in Panama City. While you're in the area, wander around the natural setting.

Avenida Balboa

Things to do

Image for Ocean to Ocean Panama Canal and Jungle Tour

Ocean to Ocean Panama Canal and Jungle Tour

£91
Per adult
96% of travellers recommend
Ocean to Ocean Panama Canal and Jungle Tour
Image for Panama Canal Partial Transit

Panama Canal Partial Transit

£119
Per adult
94% of travellers recommend
Panama Canal Partial Transit
Image for Panama Canal Tour and Gatun Lake Ecotour

Panama Canal Tour and Gatun Lake Ecotour

£107
Per adult
100% of travellers recommend
Panama Canal Tour and Gatun Lake Ecotour
See all activities in Panama City

More trip options

* Savings based on package bookings compared to the price of the same components booked separately. Savings not available on all packages. Flight-inclusive packages are ATOL protected.