Southern Indiana Luxury Holidays

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    Packages with flights are ATOL protected

Top flight + Luxury hotel deals in Southern Indiana

Price found within the past 48 hours. Click for updated prices.
The Brown Hotel

The Brown Hotel

Downtown Louisville
£1,072
per person
28 Oct - 1 Nov
found 1 day ago
Return direct flight included
Manchester (MAN) to Louisville (SDF)
9.4/10 Exceptional! (1,309 reviews)
Louisville Marriott Downtown

Louisville Marriott Downtown

Downtown Louisville
£1,280
per person
28 Oct - 1 Nov
found 1 day ago
Return direct flight included
Manchester (MAN) to Louisville (SDF)
9/10 Wonderful! (1,003 reviews)
Hyatt Regency Louisville

Hyatt Regency Louisville

Downtown Louisville
£1,143
per person
28 Oct - 1 Nov
found 1 day ago
Return direct flight included
Manchester (MAN) to Louisville (SDF)
8.8/10 Excellent! (1,007 reviews)
Friendly staff, great location, easy parking, breakfast was good, clean

Reviewed on 27 Sept 2026

Galt House Hotel Trademark Collection by Wyndham

Galt House Hotel Trademark Collection by Wyndham

Downtown Louisville
£1,087
per person
28 Oct - 1 Nov
found 1 day ago
Return direct flight included
Manchester (MAN) to Louisville (SDF)
9/10 Wonderful! (4,303 reviews)
The hotel was clean, but our room smelled very old and mattresses and pillows were very uncomfortable and needed updating. There were dated items like very old blow dryer. Staff was nice but now overly friendly like other places we’ve stayed. I won’t stay there again.

Reviewed on 28 Sept 2026

Embassy Suites Louisville Downtown

Embassy Suites Louisville Downtown

Downtown Louisville
£1,132
per person
28 Oct - 1 Nov
found 1 day ago
Return direct flight included
Manchester (MAN) to Louisville (SDF)
9/10 Wonderful! (1,363 reviews)
Great hotel. Clean and awesome staff. Perfect stay for Bourbon and Beyond.

Reviewed on 28 Sept 2026

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4 Night Luxury holidays in Southern Indiana

Price found within the past 48 hours. Click for updated prices.
The Brown Hotel

The Brown Hotel

Downtown Louisville
£1,072
per person
28 Oct - 1 Nov
found 1 day ago
Return direct flight included
Manchester (MAN) to Louisville (SDF)
9.4/10 Exceptional! (1,309 reviews)
Louisville Marriott Downtown

Louisville Marriott Downtown

Downtown Louisville
£1,280
per person
28 Oct - 1 Nov
found 1 day ago
Return direct flight included
Manchester (MAN) to Louisville (SDF)
9/10 Wonderful! (1,003 reviews)
Hyatt Regency Louisville

Hyatt Regency Louisville

Downtown Louisville
£1,143
per person
28 Oct - 1 Nov
found 1 day ago
Return direct flight included
Manchester (MAN) to Louisville (SDF)
8.8/10 Excellent! (1,007 reviews)
Friendly staff, great location, easy parking, breakfast was good, clean

Reviewed on 27 Sept 2026

Don't see what you're looking for?
See all available trips from Manchester to Southern Indiana
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All you need to know about luxury holidays in Southern Indiana

What can I expect from a luxury Southern Indiana holiday?

Luxury on holiday is all about relaxing and feeling good. Whether you choose a sumptuous spa, Michelin-starred restaurant or super-king bed is your call. Use our amenities filters to find the things that tick all your boxes.

How can I find all-inclusive luxury holidays in Southern Indiana?

Tick the all-inclusive and 5-star filters to find the crème de la crème of Southern Indiana holidays. With everything included in the package price, you can drink and dine to your heart’s content, without worrying about that bill at the end.

Can I book a cheap luxury holiday to Southern Indiana?

A luxury holiday doesn’t have to break the bank. Travel out of peak season, choose a hotel or resort a little way out or go for a last-minute getaway and you’ll find some cracking deals. Sort by price to find luxury holidays to Southern Indiana starting at £1,072. Prices and availability are subject to change. Additional terms may apply.

Are there luxury spa holidays in Southern Indiana?

For sunset massages on the shoreline and view-filled saunas, use our spa filter to find your ideal Southern Indiana spa hotel. Book a whole weekend soaking away your stresses, or hop into the spa after the beach, some golf or a local advent-ahhhh.

What should I look for when booking a luxury family holiday in Southern Indiana?

Luxury isn’t just for adults. Those little touches designed for little people make a family holiday genuinely stress free … which is the greatest luxury of all. Look for spacious suites, pools toddlers can splash in, and breakfast buffets with waffles, pancakes and Nutella galore.

Can I book luxury last-minute holidays to Southern Indiana?

You can wangle a top-notch luxury holiday in Southern Indiana for a fraction of the normal price by booking last minute. Just enter your dates and see what’s available – if you’re flexible ... even better!

Can I book a luxury holiday in Southern Indiana with free cancellation and/or flexible dates?

If you’re splashing out on a luxury holiday, make sure your money is safe by booking with free cancellation. Just use the fully refundable filter and make sure you read all the terms and conditions.

Why should I book my luxury travel to Southern Indiana with Expedia?

Nobody does luxury quite like Expedia. With so many gorgeous properties in Southern Indiana to choose from, as well as access to first-class flight deals and hire cars with horsepower, there’s no better place to book.

Top Luxury Southern Indiana Hotels

21c Museum Hotel Louisville

21c Museum Hotel Louisville

700 W Main Street Louisville KY
  • 9 min walk from KFC Yum Center
Stay at this luxury hotel in Louisville. Enjoy free Wi-Fi, a full-service spa and breakfast (surcharge). Our guests praise the restaurant and the helpful staff ...
21c Museum Hotel Louisville
West Baden Springs Hotel

West Baden Springs Hotel

8538 W Baden Ave West Baden Springs IN
  • 2 hours drive from KFC Yum Center
Stay at this luxury resort in West Baden Springs. Enjoy free Wi-Fi, a full-service spa and 15 restaurants. Popular attractions West Baden Springs Hotel and French ...
West Baden Springs Hotel
The Brown Hotel

The Brown Hotel

335 W Broadway Louisville KY
  • 14 min walk from KFC Yum Center
Stay at this luxury hotel in Louisville. Enjoy free Wi-Fi, breakfast (surcharge) and a fitness centre. Our guests praise the helpful staff and the clean rooms ...
The Brown Hotel
See all 1,650 properties in Southern Indiana
Lowest nightly price found within the past 24 hours based on a 1 night stay for 2 adults. Prices and availability subject to change. Additional terms may apply.

More holidays you might like

* Savings based on package bookings compared to the price of the same components booked separately. Savings not available on all packages. Flight-inclusive packages are ATOL protected.