Santo Spirito Holidays from £365
Book a Hotel + Flight or Car together to unlock savings
- Plan, book, travel with confidence
- Better togetherSave up to £750 when you book a flight and hotel together*
- Find the right fitWith over 300,000 hotels worldwide, it's easy to create a perfect package
- Rest easyPackages with flights are ATOL protected
Your Santo Spirito Holiday
Experience the best that Santo Spirito has to offer with a tailor-made Santo Spirito holiday package. From its walking and views to its culture, you'll quickly fall for the charms of this residential neighbourhood. Not sure what to do during your trip to Santo Spirito? Nearby attractions like Piazza Santo Spirito, Santo Spirito Basilica and Brancacci Chapel are good places to begin. Expedia is here to put your travel plans into action. Book your perfect Santo Spirito holiday today.
Price found within the past 48 hours. Click for updated prices.
Hotel Villa Liana
Historic Centre of Florence
£557
per person
2 Oct - 7 Oct
found 1 day ago
Return direct flight included
London (LGW) to Florence (FLR)
8.8/10 Excellent! (360 reviews)
clean, spacious, well-stocked with toiletries and breakfast items too. walkable distance to all iconic sites. Grace, the breakfast host, did an incredible job, very welcoming & served with options for hot coffee drinks. All together, wonderful, memorable stay!!
Reviewed on 23 May 2026
The Moon Boutique Hotel & Spa
Historic Centre of Florence
£566
per person
20 Oct - 23 Oct
found 16 hours ago
Return direct flight included
Birmingham (BHX) to Florence (FLR)
9.6/10 Exceptional! (584 reviews)
Arrived and was very welcomed at the hotel
Beautiful and clean
The staff very helpful and respectful
Very much cooperative and very hospitable
Reviewed on 25 Aug 2026
Where to stay in Santo Spirito
Find the best Santo Spirito areas and neighborhoods for the activities you enjoy most. Learn more about Santo Spirito
Historic Centre of Florence
10 out of top 10 points of interest in this area
Lose yourself in the Renaissance charm of Florence’s old town, where masterpieces by Brunelleschi and Giotto line up alongside cafés, gelato shops and trattorias.
Duomo
Visitors to Duomo rave about its fascinating museums, stunning cathedral and popular shops. You might also want to make some time to see Piazza del Duomo or Piazza di Santa Maria Novella while you're exploring the neighbourhood.
Santa Maria Novella
Enjoy the popular shops in Santa Maria Novella. Piazza di Santa Maria Novella is a worthwhile stop, and you can jump on the metro at Porta al Prato - Leopolda Tram Stop or Fratelli Rosselli Tram Stop to see more of Porta al Prato.
San Giovanni
If you're spending some time in San Giovanni, Piazza della Repubblica and Via de' Calzaiuoli are top sights worth seeing.
Santa Croce
Santa Croce is known for its interesting museums, and you can plan a trip to Basilica of Santa Croce and Piazza Santa Croce while you're in town.
Top hotels in Santo Spirito
Hotel Horto Convento
Viale Ariosto, 13 Florence FI
Fully refundableReserve now, pay when you stay
£133
31 Aug - 1 Sept
includes taxes & fees
9.8/10 Exceptional! (713 reviews)
"Good location, close to main attractions."
Reviewed on 21 Aug 2026
La Torre Del Cestello
Via Borgo San Frediano, 8 Florence FI
£92
31 Aug - 1 Sept
includes taxes & fees
9.2/10 Wonderful! (300 reviews)
"We had a wonderful 3 night stay here. The room was spacious with beautiful views overlooking the Arno river. The air conditioning worked very well in the room and was much appreciated during a heat wave in August. The location could not be beat. It is away from the major crowds, but still surrounded ..."
Reviewed on 25 Aug 2026
UNA Hotels Vittoria Firenze
Via Pisana 59 Florence FI
£81
30 Aug - 31 Aug
includes taxes & fees
8.4/10 Very good! (1,006 reviews)
"Very clean, nice rooms, staff and great breakfast / evening food in the restaurant. Location 20min walk to main Santa Maria Station."
Reviewed on 16 Aug 2026
Lowest nightly price found within the past 24 hours based on a 1 night stay for 2 adults. Prices and availability subject to change. Additional terms may apply.
Frequently asked questions
How much does a Santo Spirito travel package cost?
We make it simple for everyone to travel, with Santo Spirito travel packages starting from as little as £365. You'll have the flexibility to bundle your preferred hotels, airlines and car rental. For the ultimate escape, why not add a few tours and experiences to your itinerary?
If I'm not able to travel, can I cancel my Santo Spirito travel package?
Don't worry if you're rethinking your Santo Spirito travel package — it's possible to change or amend your booking. And if you've booked it within 24 hours, you may be able to do it for free. However, bookings made more than 24 hours ago may incur fees from your airline, hotel or car rental company. We get that life can occasionally throw a spanner in the travel works, so make your way to our Customer Service Portal if that occurs. When you're ready to make changes, we're here to help.
How do I get a cheap travel package to Santo Spirito?
One of the easiest ways to save money (and time) is to combine your bookings with Expedia. Hotels, flights, activities and rental cars — we've got them all covered. Pick and choose a combination that suits you and watch your savings stack up. We know a package deal is never one-size-fits-all. That's why we offer over 550 air carriers and 1,000,000 hotel options across the world, which lets you customize your Santo Spirito holiday.
Does Expedia offer Book Now, Pay Later Santo Spirito holidays?
Good news! We do. Expedia has teamed up with online lender Klarna to help you easily pay for your holiday in manageable instalments. Simply pick the payment plan that suits you best during the checkout process and take the stress out of budgeting for your next trip. Don't forget to bundle your accommodation, car hire and flights with Expedia to get the biggest bang for your buck. Consider these flexible payment options below:
- Pay monthly holidays: Escape on that dream holiday sooner with Klarna's convenient monthly instalment plans. If paying bite-sized amounts each month sounds right for you, pick this option during the checkout process.
- Pay in instalments holidays: Like the idea of paying off your holiday in multiple transactions? Then go for this Book Now, Pay Later option with Klarna.
- Low deposit holidays: If paying a small percentage of your getaway (rather than the full total upfront) makes it easier to click that "book now" button, opt for a low deposit holiday payment plan from Klarna.
What are the top hotels in Santo Spirito?
Get your holiday off to a good start by locking in a room at B&B Monte Oliveto. It's one of most popular hotels in Santo Spirito. Another comfortable option is Ottantotto Firenze.
How far in advance should I book my Santo Spirito holiday?
While not all air carriers release ticket prices early, you can normally compare international fares on Expedia up to a year in advance. This is the time you can score some fantastic deals. If you've left things to the last minute, you might still be in luck. Low prices occasionally become available only weeks prior to departure.
What does an Expedia Santo Spirito travel package include?
With Expedia, you can select a combination of car rentals, hotels and flights to build your ideal Santo Spirito package. Once you've made your booking, you can add on all the fun stuff like sightseeing tours and activities. Don't forget — the more you bundle, the bigger the savings!
What should I know before booking a Santo Spirito travel package?
Locking in all the parts of your escape together is one of the easiest ways to save. Bundle car rentals, airfares and hotels into a handy package. But your options don't end at hotels. Expedia features all sorts of properties, including holiday rentals like beachside villas and spacious residences. Your choices are almost endless!
Can I choose my airline with a Santo Spirito Expedia travel package?
Expedia offers access to more than 550 airline partners worldwide, so you definitely can. Simply select the carrier you want and create the perfect Santo Spirito holiday.
Stay near popular Santo Spirito attractions
Piazza Santo Spirito
9.6/10 (8 reviews)
Learn about the local history of Florence with a stop at Piazza Santo Spirito. Discover the acclaimed art galleries and notable monuments in this vibrant area.
Porta Romana
8.6/10 (29 reviews)
Porta Romana is just one of the places to see in Arcetri, so why not enjoy the other things to explore during your travels? Discover the fascinating museums and churches in this vibrant area.
Brancacci Chapel
10.0/10 (1 review)
A dazzling array of Renaissance frescoes adorn the walls of the most famous chapel of Florence’s 750-year-old Church of Santa Maria del Carmine.
Santo Spirito Basilica
8.0/10 (3 reviews)
Learn about the local history of Florence when you take a trip to Santo Spirito Basilica. Stroll along the riverfront or visit the notable monuments in this vibrant area.
Piazza del Carmine
10.0/10 (3 reviews)
You can learn about the history of Florence with a trip to Piazza del Carmine. Amble around this vibrant area's riverfront or experience its acclaimed art galleries.
Santa Maria della Carmine
10.0/10 (1 review)
You can learn about the history of Florence with a visit to Santa Maria della Carmine. Visit the stunning cathedral and notable monuments in this vibrant area.
Il Nabucco di Matteo Gabellini
You can study the exhibits at Il Nabucco di Matteo Gabellini, a museum with a story of its own, during your travels to Florence. Discover the fascinating museums and stunning cathedral in this vibrant area.
Church of St Felix
Church of St Felix is just one of the places to see in Florence, so why not enjoy the other things to explore during your travels? Amble around this vibrant area's riverfront or experience its fascinating museums.
Things to do
Florence: Pasta Cooking Class with Unlimited Wine
£14
per adult
94% of travellers recommend
City Sightseeing Florence Hop-on Hop-off Bus Tour
£21
per adult
76% of travellers recommend
Best of Florence Tour with David at Accademia & Duomo (with VIP option)
£57
per adult
96% of travellers recommend
* Savings based on package bookings compared to the price of the same components booked separately. Savings not available on all packages. Flight-inclusive packages are ATOL protected.