Santo Spirito Holidays from £472

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Your Santo Spirito Holiday

Experience the best that Santo Spirito has to offer with a tailor-made Santo Spirito holiday package. From its walking and views to its culture, you'll quickly fall for the charms of this residential neighbourhood. Not sure what to do during your trip to Santo Spirito? Nearby attractions like Piazza Santo Spirito, Santo Spirito Basilica and Brancacci Chapel are good places to begin. Expedia is here to put your travel plans into action. Book your perfect Santo Spirito holiday today.

Price found within the past 48 hours. Click for updated prices.
Cappuccina Country Resort

Cappuccina Country Resort

4 out of 5
Save 100% on your flight
Price was £795, price is now £472 per person
£472
per person
2 Jul - 6 Jul
found 1 day ago
Return direct flight included
Manchester (MAN) to Florence (FLR)
8.6/10 Excellent! (94 reviews)
Great stay. Very good experience.

Reviewed on 20 Oct 2025

Aurum Uffizi

Aurum Uffizi

4 out of 5
Historic Centre of Florence
Save 100% on your flight
Price was £1,560, price is now £771 per person
£771
per person
24 May - 29 May
found 1 day ago
Return flight included
London (LON) to Florence (FLR)
7.6/10 Good! (1,000 reviews)
The room was clean and newly renovated. Having breakfast included was great for a quick bite so I could focus on exploring instead of searching and waiting in line. Would definitely recommend a stay here

Reviewed on 9 Apr 2026

Aurum Firenze

Aurum Firenze

4 out of 5
Historic Centre of Florence
Save 100% on your flight
Price was £1,126, price is now £632 per person
£632
per person
15 May - 19 May
found 8 hours ago
Return direct flight included
Birmingham (BHX) to Florence (FLR)
7.6/10 Good! (1,006 reviews)
Super clean room, modern, good shower and bed, nice and quiet, 10 minutes from the train station, breakfast was done in time slots and was ok maybe could have had more selection, staff were friendly, my only bugbear was the WiFi was really slow and i ended up using my hot-spot instead

Reviewed on 12 Apr 2026

Eurostars Florence Boutique

Eurostars Florence Boutique

4 out of 5
Historic Centre of Florence
Save 100% on your flight
Price was £860, price is now £494 per person
£494
per person
16 Jun - 19 Jun
found 1 day ago
Return flight included
London (LON) to Florence (FLR)
8.6/10 Excellent! (483 reviews)
The room was clean and the staff very accommodating. The breakfast was quite sufficient and had a good variety. The location is great. It's a short walk from the square, shopping and from restaurants.

Reviewed on 13 Dec 2025

Residenza Florentia

Residenza Florentia

1 out of 5
Historic Centre of Florence
Save 100% on your flight
Price was £967, price is now £576 per person
£576
per person
23 May - 26 May
found 1 day ago
Return direct flight included
Manchester (MAN) to Florence (FLR)
8.4/10 Very Good! (48 reviews)
The hotel staff were extremely friendly and highly professional – honestly, I’ve rarely experienced this level of service. The hotel is in a perfect location, right in the city center, which is a huge advantage. Everything was clean, well-maintained, and very comfortable. I would highly recommend this place to anyone looking for quality accommodation.

Reviewed on 6 Apr 2026

Where to stay in Santo Spirito

Find the best Santo Spirito areas and neighborhoods for the activities you enjoy most. Learn more about Santo Spirito
Historic Centre of Florence

Historic Centre of Florence

10 out of top 10 points of interest in this area

Lose yourself in the Renaissance charm of Florence’s old town, where masterpieces by Brunelleschi and Giotto line up alongside cafés, gelato shops and trattorias.

Find hotels in Historic Centre of Florence

Top hotels in Santo Spirito

Hotel Horto Convento

Hotel Horto Convento

4 out of 5
Viale Ariosto, 13 Florence FI
Fully refundableReserve now, pay when you stay
The price is £252 per night from 21 Apr to 22 Apr
£252
21 Apr - 22 Apr
includes taxes & fees
9.8/10 Exceptional! (634 reviews)
Everyone very helpful

Reviewed on 7 Apr 2026

Hotel Horto Convento
Palazzo Mannaioni Suites

Palazzo Mannaioni Suites

4 out of 5
Via Maffia 9 - 17r Florence FI
The price is £188 per night from 20 Apr to 21 Apr
£188
20 Apr - 21 Apr
includes taxes & fees
9.2/10 Wonderful! (1,099 reviews)
One of my favorite places to stay in Florence. Nice área with a lot of places to eat at a walking distance. The staff is always friendly and ready to assist you. The rooms are fabolous and some have a great view.

Reviewed on 12 Apr 2026

Palazzo Mannaioni Suites
La Torre Del Cestello

La Torre Del Cestello

Via Borgo San Frediano, 8 Florence FI
Fully refundable
The price is £144 per night from 23 Apr to 24 Apr
£144
23 Apr - 24 Apr
includes taxes & fees
9.2/10 Wonderful! (248 reviews)
Very nice place in the centre of town. Extremely helpful and friendly staff. Room was exactly as advertised , spacious with a great view overlooking the river and old town. If i go back to Florence i would happily stay here again.

Reviewed on 7 Apr 2026

La Torre Del Cestello
See all 495 properties in Santo Spirito
Lowest nightly price found within the past 24 hours based on a 1 night stay for 2 adults. Prices and availability subject to change. Additional terms may apply.
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Frequently asked questions

How much does a Santo Spirito travel package cost?
We make it simple for everyone to travel, with Santo Spirito travel packages starting from as little as £472. You'll have the flexibility to bundle your preferred hotels, airlines and car rental. For the ultimate escape, why not add a few tours and experiences to your itinerary?
If I'm not able to travel, can I cancel my Santo Spirito travel package?
Don't worry if you're rethinking your Santo Spirito travel package — it's possible to change or amend your booking. And if you've booked it within 24 hours, you may be able to do it for free. However, bookings made more than 24 hours ago may incur fees from your airline, hotel or car rental company. We get that life can occasionally throw a spanner in the travel works, so make your way to our Customer Service Portal if that occurs. When you're ready to make changes, we're here to help.
How do I get a cheap travel package to Santo Spirito?
One of the easiest ways to save money (and time) is to combine your bookings with Expedia. Hotels, flights, activities and rental cars — we've got them all covered. Pick and choose a combination that suits you and watch your savings stack up. We know a package deal is never one-size-fits-all. That's why we offer over 550 air carriers and 1,000,000 hotel options across the world, which lets you customize your Santo Spirito holiday.
Does Expedia offer Book Now, Pay Later Santo Spirito holidays?
Good news! We do. Expedia has teamed up with online lender Klarna to help you easily pay for your holiday in manageable instalments. Simply pick the payment plan that suits you best during the checkout process and take the stress out of budgeting for your next trip. Don't forget to bundle your accommodation, car hire and flights with Expedia to get the biggest bang for your buck. Consider these flexible payment options below:

  • Pay monthly holidays: Escape on that dream holiday sooner with Klarna's convenient monthly instalment plans. If paying bite-sized amounts each month sounds right for you, pick this option during the checkout process.
  • Pay in instalments holidays: Like the idea of paying off your holiday in multiple transactions? Then go for this Book Now, Pay Later option with Klarna.
  • Low deposit holidays: If paying a small percentage of your getaway (rather than the full total upfront) makes it easier to click that "book now" button, opt for a low deposit holiday payment plan from Klarna.

What are the top hotels in Santo Spirito?
Get your holiday off to a good start by locking in a room at B&B Monte Oliveto. It's one of most popular hotels in Santo Spirito. Another comfortable option is Ottantotto Firenze.
How far in advance should I book my Santo Spirito holiday?
While not all air carriers release ticket prices early, you can normally compare international fares on Expedia up to a year in advance. This is the time you can score some fantastic deals. If you've left things to the last minute, you might still be in luck. Low prices occasionally become available only weeks prior to departure.
What does an Expedia Santo Spirito travel package include?
With Expedia, you can select a combination of car rentals, hotels and flights to build your ideal Santo Spirito package. Once you've made your booking, you can add on all the fun stuff like sightseeing tours and activities. Don't forget — the more you bundle, the bigger the savings!
What should I know before booking a Santo Spirito travel package?
Locking in all the parts of your escape together is one of the easiest ways to save. Bundle car rentals, airfares and hotels into a handy package. But your options don't end at hotels. Expedia features all sorts of properties, including holiday rentals like beachside villas and spacious residences. Your choices are almost endless!
Can I choose my airline with a Santo Spirito Expedia travel package?
Expedia offers access to more than 550 airline partners worldwide, so you definitely can. Simply select the carrier you want and create the perfect Santo Spirito holiday.

Popular places to visit

Brancacci Chapel

Brancacci Chapel

A dazzling array of Renaissance frescoes adorn the walls of the most famous chapel of Florence’s 750-year-old Church of Santa Maria del Carmine.

Brancacci Chapel

Things to do

Small-Group Wine Tasting Experience in the Tuscan Countryside

Small-Group Wine Tasting Experience in the Tuscan Countryside

£77
per adult
98% of travellers recommend
Small-Group Wine Tasting Experience in the Tuscan Countryside
Skip-the-Line Duomo: Priority-Access 30-Minute Guided Tour

Skip-the-Line Florence Duomo: Priority-Access Express Guided Tour

£20
per adult
80% of travellers recommend
Skip-the-Line Florence Duomo: Priority-Access Express Guided Tour
Florence: San Gimignano, Siena, Monteriggioni, Chianti & Lunch with Wine

Florence: San Gimignano, Siena, Monteriggioni, Chianti & Lunch with Wine

£69
per adult
88% of travellers recommend
Florence: San Gimignano, Siena, Monteriggioni, Chianti & Lunch with Wine
See all activities in Florence

* Savings based on package bookings compared to the price of the same components booked separately. Savings not available on all packages. Flight-inclusive packages are ATOL protected.