Santo Spirito Holidays

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    Save up to £750 when you book a flight and hotel together*

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    With over 300,000 hotels worldwide, it's easy to create a perfect package

  • Rest easy

    Packages with flights are ATOL protected

Your Santo Spirito Holiday

Experience the best that Santo Spirito has to offer with a tailor-made Santo Spirito holiday package. From its walking and views to its culture, you'll quickly fall for the charms of this residential neighbourhood. Not sure what to do during your trip to Santo Spirito? Nearby attractions like Piazza Santo Spirito, Santo Spirito Basilica and Brancacci Chapel are good places to begin. Expedia is here to put your travel plans into action. Book your perfect Santo Spirito holiday today.

Price found within the past 48 hours. Click for updated prices.
  • Quadruple Room | Premium bedding, minibar, in-room safe, blackout curtains
    Aug 17 - Aug 23

    Aurum Firenze + Flight

    Historic Centre of Florence
    6 nights
    4.0 star property
    7.6/10 - Good (1,004 reviews)
    "The room smelled pretty bad even with the windows open. There's also a bunch of mosquitoes flying around, but everything else was ok!"
    Reviewed May 27, 2026
    Return • London (LGW) - Florence (FLR)
    LGW - FLR • Direct FLR - LGW • Direct
    Save 100% on your flight
    £859
    £465
    per traveller
    found 12 hours ago
    Aurum Firenze
  • Premium bedding, in-room safe, free cots/infant beds, free WiFi
    Aug 17 - Aug 23

    Aurum Uffizi + Flight

    Historic Centre of Florence
    6 nights
    4.0 star property
    7.6/10 - Good (1,001 reviews)
    "Excelente servicio, las habitaciones las limpiaron todos los días, el desayuno muy completo, además muy cerca de plazas principales"
    Reviewed May 27, 2026
    Return • London (LGW) - Florence (FLR)
    LGW - FLR • Direct FLR - LGW • Direct
    Save 100% on your flight
    £929
    £491
    per traveller
    found 12 hours ago
    Aurum Uffizi
  • Rooftop terrace
    Jul 31 - Aug 3

    Donati Luxury Tower Suites + Flight

    Historic Centre of Florence
    3 nights
    5.0 star property
    9.6/10 - Exceptional (65 reviews)
    "Agradable estancia. Excelente servicio. La habitación la mantenían siempre limpia. Todo queda cerca del área. Muy recomendable"
    Reviewed May 23, 2026
    Return • London (LGW) - Florence (FLR)
    LGW - FLR • Direct FLR - LGW • Direct
    Save 100% on your flight
    £1,246
    £704
    per traveller
    found 1 day ago
    Donati Luxury Tower Suites
  • Exterior
    Aug 20 - Aug 24

    Park Hotel Villa Ariston + Flight

    Camaiore
    4 nights
    4.0 star property
    8.8/10 - Excellent (131 reviews)
    "Highly recommend the Park Villa Ariston! The property is very clean and the staff are amazing. High praise for the breakfast and pool. We hope to return soon"
    Reviewed May 14, 2026
    Return • London (LGW) - Florence (FLR)
    LGW - FLR • Direct FLR - LGW • Direct
    Save 100% on your flight
    £876
    £524
    per traveller
    found 7 hours ago
    Park Hotel Villa Ariston
  • Turkish bath/hammam
    Jul 6 - Jul 17

    Boccioleto Resort&Spa + Flight

    Montaione
    11 nights
    4.0 star property
    9.2/10 - Wonderful (119 reviews)
    "Staff were very friendly and the rooms were clean and spacious! "
    Reviewed November 17, 2025
    Return • London (LGW) - Rome (FCO)
    LGW - FCO • Direct FCO - LGW • Direct
    Save 100% on your flight
    £1,205
    £729
    per traveller
    found 1 day ago
    Boccioleto Resort&Spa

Where to stay in Santo Spirito

Find the best Santo Spirito areas and neighborhoods for the activities you enjoy most. Learn more about Santo Spirito
Historic Centre of Florence

Historic Centre of Florence

10 out of top 10 points of interest in this area

Lose yourself in the Renaissance charm of Florence’s old town, where masterpieces by Brunelleschi and Giotto line up alongside cafés, gelato shops and trattorias.

Find hotels in Historic Centre of Florence

Top hotels in Santo Spirito

Hotel Horto Convento

Hotel Horto Convento

4 out of 5
Viale Ariosto, 13 Florence FI
Fully refundableReserve now, pay when you stay
The price is £217 per night from 28 Jun to 29 Jun
£217
28 Jun - 29 Jun
includes taxes & fees
9.8/10 Exceptional! (666 reviews)
"Beautiful, quiet surrounds. Walking distance to all major landmarks in Florence. Very friendly and helpful staff. No restaurant on site but breakfast is lovely and Giovanni has wonderful recommendations for where to eat. I didn’t have them but I’m told the cocktails are delicious. Didn’t use the ..."

Reviewed on 24 May 2026

Hotel Horto Convento
Palazzo Mannaioni Suites

Palazzo Mannaioni Suites

4 out of 5
Via Maffia 9 - 17r Florence FI
9.2/10 Wonderful! (1,121 reviews)
"The accommodations were great! Location is very central, can walk to anything. Probably the best hotel of our vacation in that regard. Word of caution if arriving with a car, this hotel is located "deep" inside a ZTL, or limited transit zone. The hotel/staff make no accommodation for this. We arrived ..."

Reviewed on 27 May 2026

Get rates
Palazzo Mannaioni Suites
La Torre Del Cestello

La Torre Del Cestello

Via Borgo San Frediano, 8 Florence FI
Fully refundableReserve now, pay when you stay
The price is £158 per night from 1 Jun to 2 Jun
£158
1 Jun - 2 Jun
includes taxes & fees
9/10 Wonderful! (257 reviews)
"Walking distant to everything"

Reviewed on 27 May 2026

La Torre Del Cestello
See all 506 properties in Santo Spirito
Lowest nightly price found within the past 24 hours based on a 1 night stay for 2 adults. Prices and availability subject to change. Additional terms may apply.
All Inclusive Holidays
All Inclusive Holidays
Beach Holidays
Beach Holidays
Family Friendly Holidays
Family Friendly Holidays

Frequently asked questions

How much does a Santo Spirito travel package cost?
We make it simple for everyone to travel, with Santo Spirito travel packages starting from as little as . You'll have the flexibility to bundle your preferred hotels, airlines and car rental. For the ultimate escape, why not add a few tours and experiences to your itinerary?
If I'm not able to travel, can I cancel my Santo Spirito travel package?
Don't worry if you're rethinking your Santo Spirito travel package — it's possible to change or amend your booking. And if you've booked it within 24 hours, you may be able to do it for free. However, bookings made more than 24 hours ago may incur fees from your airline, hotel or car rental company. We get that life can occasionally throw a spanner in the travel works, so make your way to our Customer Service Portal if that occurs. When you're ready to make changes, we're here to help.
How do I get a cheap travel package to Santo Spirito?
One of the easiest ways to save money (and time) is to combine your bookings with Expedia. Hotels, flights, activities and rental cars — we've got them all covered. Pick and choose a combination that suits you and watch your savings stack up. We know a package deal is never one-size-fits-all. That's why we offer over 550 air carriers and 1,000,000 hotel options across the world, which lets you customize your Santo Spirito holiday.
Does Expedia offer Book Now, Pay Later Santo Spirito holidays?
Good news! We do. Expedia has teamed up with online lender Klarna to help you easily pay for your holiday in manageable instalments. Simply pick the payment plan that suits you best during the checkout process and take the stress out of budgeting for your next trip. Don't forget to bundle your accommodation, car hire and flights with Expedia to get the biggest bang for your buck. Consider these flexible payment options below:

  • Pay monthly holidays: Escape on that dream holiday sooner with Klarna's convenient monthly instalment plans. If paying bite-sized amounts each month sounds right for you, pick this option during the checkout process.
  • Pay in instalments holidays: Like the idea of paying off your holiday in multiple transactions? Then go for this Book Now, Pay Later option with Klarna.
  • Low deposit holidays: If paying a small percentage of your getaway (rather than the full total upfront) makes it easier to click that "book now" button, opt for a low deposit holiday payment plan from Klarna.

What are the top hotels in Santo Spirito?
Get your holiday off to a good start by locking in a room at B&B Monte Oliveto. It's one of most popular hotels in Santo Spirito. Another comfortable option is Ottantotto Firenze.
How far in advance should I book my Santo Spirito holiday?
While not all air carriers release ticket prices early, you can normally compare international fares on Expedia up to a year in advance. This is the time you can score some fantastic deals. If you've left things to the last minute, you might still be in luck. Low prices occasionally become available only weeks prior to departure.
What does an Expedia Santo Spirito travel package include?
With Expedia, you can select a combination of car rentals, hotels and flights to build your ideal Santo Spirito package. Once you've made your booking, you can add on all the fun stuff like sightseeing tours and activities. Don't forget — the more you bundle, the bigger the savings!
What should I know before booking a Santo Spirito travel package?
Locking in all the parts of your escape together is one of the easiest ways to save. Bundle car rentals, airfares and hotels into a handy package. But your options don't end at hotels. Expedia features all sorts of properties, including holiday rentals like beachside villas and spacious residences. Your choices are almost endless!
Can I choose my airline with a Santo Spirito Expedia travel package?
Expedia offers access to more than 550 airline partners worldwide, so you definitely can. Simply select the carrier you want and create the perfect Santo Spirito holiday.

Popular places to visit

Brancacci Chapel

Brancacci Chapel

A dazzling array of Renaissance frescoes adorn the walls of the most famous chapel of Florence’s 750-year-old Church of Santa Maria del Carmine.

Brancacci Chapel

Things to do

City Sightseeing Florence Hop-on Hop-off

City Sightseeing Florence Hop-on Hop-off Bus Tour

£25
per adult
76% of travellers recommend
City Sightseeing Florence Hop-on Hop-off Bus Tour
Small-Group Wine Tasting Experience in the Tuscan Countryside

Small-Group Wine Tasting Experience in the Tuscan Countryside

£77
per adult
98% of travellers recommend
Small-Group Wine Tasting Experience in the Tuscan Countryside
Skip the Line: Florence's Accademia Gallery Priority Entrance Ticket

Skip the Line: Florence's Accademia Gallery Priority Entrance Ticket

£30
per adult
88% of travellers recommend
Skip the Line: Florence's Accademia Gallery Priority Entrance Ticket
See all activities in Florence

* Savings based on package bookings compared to the price of the same components booked separately. Savings not available on all packages. Flight-inclusive packages are ATOL protected.