Title: Cayos Zapatilla Adventure Holidays 2025/2026 | Expedia.co.uk ![](https://images.trvl-media.com/place/6246124/962b07b0-9b6f-43f9-a3da-ab98125d9cc6.jpg?impolicy=fcrop&w=1200&h=300&q=medium) # Cayos Zapatilla Adventure Holidays ## Book a Adventure Hotel + Flight or Car together to unlock savings Photo by Isa - ## Plan, book, travel with confidence - ### Better together Save up to £335 when you book a flight and hotel together\* - ### Find the right fit With over 300,000 hotels worldwide, it's easy to create a perfect package - ### Rest easy Packages with flights are ATOL protected ## Top flight + Adventure hotel deals in Cayos Zapatilla Price found within the past 48 hours. Click for updated prices. ![Central Hotel Panama Casco Viejo](https://images.trvl-media.com/lodging/16000000/15690000/15683600/15683502/3165768f_y.jpg?impolicy=fcrop&w=900&h=506&q=mediumHigh) ### Central Hotel Panama Casco Viejo Casco Viejo £754 per person 9 Jan - 13 Jan found 1 hour ago Return direct flight included Newark Liberty Intl. Airport (EWR) to Panama City (PTY) 9/10 Wonderful! (1,005 reviews) Staffs were wonderful. Reviewed on 28 Oct 2025 [](https://expedia.co.uk/go/package/search/FlightHotel/2026-01-09/2026-01-13/?FromAirport=EWR&Destination=PTY&NumRoom=1&NumAdult=2&NumChild=0&hotelId=15683502&paandie=true&HotelClass=40&dealMarker=9QQWmg7FEplEjIJhxEEjCFvIL9UroEIMEMuDyEkej-PEJZgFluPVFqW4cgLpy-fb) ![Casa Mallet by Wynwood House](https://images.trvl-media.com/lodging/100000000/99780000/99778900/99778891/dfb3f761_y.jpg?impolicy=fcrop&w=900&h=506&q=mediumHigh) ### Casa Mallet by Wynwood House Casco Viejo £1,754 per person 26 Dec - 31 Dec found 1 day ago Return flight included Bridgetown (BGI) to Panama City (PTY) 9.8/10 Exceptional! (24 reviews) It was very relaxing to stay at the historical and cutely renovated apartment. Great aesthetic. Lively apartment, very well decorated! Right the middle of everything in the beautiful town of Casco Veijo. Vibrant lanes, boutique stores, cafes and restaurants near by. We had an amazing time staying for 2 nights at this apartment. Reviewed on 23 Jul 2025 [](https://expedia.co.uk/go/package/search/FlightHotel/2025-12-26/2025-12-31/?FromAirport=BGI&Destination=PTY&NumRoom=1&NumAdult=2&NumChild=0&hotelId=99778891&paandie=true&HotelClass=40&dealMarker=hqrzlFyS8DwRVlr4irIrHjrPxgVZWwC30DB5h3jo6msGx824JnvQIMWjzPyisHrb) ![Megapolis Hotel Panamá](https://images.trvl-media.com/lodging/92000000/92000000/91995600/91995575/4aee4896_y.jpg?impolicy=fcrop&w=900&h=506&q=mediumHigh) ### Megapolis Hotel Panamá San Francisco £885 per person 26 Dec - 31 Dec found 1 day ago Return flight included Bridgetown (BGI) to Panama City (PTY) 8.4/10 Very Good! (1,127 reviews) Great quality customer service. The food was delicious and all the staff very kind. The room had an amazing view and it was very comfortable. The location is convenient a few good things ti see are relatively close. Reviewed on 4 Nov 2025 [](https://expedia.co.uk/go/package/search/FlightHotel/2025-12-26/2025-12-31/?FromAirport=BGI&Destination=PTY&NumRoom=1&NumAdult=2&NumChild=0&hotelId=91995575&paandie=true&HotelClass=40&dealMarker=hqrzlFyS8DwRVlr4irIrHjrPxgVZWwC30DB5h3jo6mv8AtYlLCt6VJuYpzja7br5) ![Hotel La Compañía Casco Antiguo](https://images.trvl-media.com/lodging/72000000/71140000/71136000/71135966/02cb9f51_y.jpg?impolicy=fcrop&w=900&h=506&q=mediumHigh) ### Hotel La Compañía Casco Antiguo Casco Viejo £1,998 per person 26 Dec - 31 Dec found 1 day ago Return flight included Bridgetown (BGI) to Panama City (PTY) 9.8/10 Exceptional! (236 reviews) Many shops and restaurants nearby and the hotel is located in a beautiful area Reviewed on 5 Nov 2025 [](https://expedia.co.uk/go/package/search/FlightHotel/2025-12-26/2025-12-31/?FromAirport=BGI&Destination=PTY&NumRoom=1&NumAdult=2&NumChild=0&hotelId=71135966&paandie=true&HotelClass=40&dealMarker=hqrzlFyS8DwRVlr4irIrHjrPxgVZWwC30DB5h3jo6muFFLPR_YKRWfw_wgVKggzR) ![Dreams Playa Bonita Panama - All Inclusive](https://images.trvl-media.com/lodging/13000000/12450000/12445600/12445554/7c338453_y.jpg?impolicy=fcrop&w=900&h=506&q=mediumHigh) ### Dreams Playa Bonita Panama - All Inclusive £996 per person 9 Jan - 13 Jan found 1 hour ago Return direct flight included Newark Liberty Intl. Airport (EWR) to Panama City (PTY) 7.4/10 Good! (1,006 reviews) Great staff, room, amenities and property. Reviewed on 5 Nov 2025 [](https://expedia.co.uk/go/package/search/FlightHotel/2026-01-09/2026-01-13/?FromAirport=EWR&Destination=PTY&NumRoom=1&NumAdult=2&NumChild=0&hotelId=12445554&paandie=true&HotelClass=40&dealMarker=d8WXsIpRSRqP6I9NTyMJXuBgXamRjB1Tx8GZ9i2FTpgK7iRKD75y8QwgA8fBQDcj) Don't see what you're looking for? See all available trips from Newark Liberty Intl. Airport to Cayos Zapatilla [View all trips](https://expedia.co.uk/go/package/search/FlightHotel/2025-12-07/2025-12-14/?FromAirport=EWR&Destination=PAC&NumRoom=1&NumAdult=2&NumChild=0&paandie=true) ## 5\* Adventure holidays in Cayos Zapatilla Price found within the past 48 hours. Click for updated prices. ![Hotel Riu Plaza Panama](https://images.trvl-media.com/lodging/4000000/3910000/3900400/3900395/1eaf88f5_y.jpg?impolicy=fcrop&w=900&h=506&q=mediumHigh) ### Hotel Riu Plaza Panama Bella Vista £589 per person 9 Jan - 13 Jan found 1 day ago Return direct flight included Newark Liberty Intl. Airport (EWR) to Panama City (PTY) 9/10 Wonderful! (4,386 reviews) The room was clean and the staff are courteous. Reviewed on 6 Nov 2025 [](https://expedia.co.uk/go/package/search/FlightHotel/2026-01-09/2026-01-13/?FromAirport=EWR&Destination=PTY&NumRoom=1&NumAdult=2&NumChild=0&hotelId=3900395&paandie=true&HotelClass=50&dealMarker=5SCtZfXSGJnbEuuNfbozKTC5tWAmEBqUWdsm-Pj9DJKuMWB527HHDQ3rB4uXDMih) ![The Santa Maria, A Luxury Collection Hotel & Golf Resort, Panama City](https://images.trvl-media.com/lodging/21000000/20960000/20958600/20958573/d80494b9_y.jpg?impolicy=fcrop&w=900&h=506&q=mediumHigh) ### The Santa Maria, A Luxury Collection Hotel & Golf Resort, Panama City Juan Diaz £768 per person 9 Jan - 13 Jan found 1 day ago Return direct flight included Newark Liberty Intl. Airport (EWR) to Panama City (PTY) 9.6/10 Exceptional! (618 reviews) This is a quality hotel with quality service. Recommend it Reviewed on 30 Oct 2025 [](https://expedia.co.uk/go/package/search/FlightHotel/2026-01-09/2026-01-13/?FromAirport=EWR&Destination=PTY&NumRoom=1&NumAdult=2&NumChild=0&hotelId=20958573&paandie=true&HotelClass=50&dealMarker=5SCtZfXSGJnbEuuNfbozKTC5tWAmEBqUWdsm-Pj9DJJgPOIdKW39Q6gpZHmpTuId) ![Waldorf Astoria Panama](https://images.trvl-media.com/lodging/5000000/4960000/4952100/4952056/e7e98c5e_y.jpg?impolicy=fcrop&w=900&h=506&q=mediumHigh) ### Waldorf Astoria Panama Bella Vista £749 per person 9 Jan - 13 Jan found 1 day ago Return direct flight included Newark Liberty Intl. Airport (EWR) to Panama City (PTY) 9/10 Wonderful! (1,001 reviews) The kitchen and dining staff were excellent for breakfast shout out to Mr. Will for making the special coffee in the morning. Room service was fantastic the food was very good you did have a limited menu but if you told them what you want they can pretty much take care of what you would like to have. Only negative was the pool looked a little green. Reviewed on 6 Nov 2025 [](https://expedia.co.uk/go/package/search/FlightHotel/2026-01-09/2026-01-13/?FromAirport=EWR&Destination=PTY&NumRoom=1&NumAdult=2&NumChild=0&hotelId=4952056&paandie=true&HotelClass=50&dealMarker=5SCtZfXSGJnbEuuNfbozKTC5tWAmEBqUWdsm-Pj9DJK8U3Y0FD61fEZDYvL6lW4n) Don't see what you're looking for? See all available trips from Newark Liberty Intl. Airport to Cayos Zapatilla [View all trips](https://expedia.co.uk/go/package/search/FlightHotel/2025-12-07/2025-12-14/?FromAirport=EWR&Destination=PAC&NumRoom=1&NumAdult=2&NumChild=0&paandie=true) ## 4 Night Adventure holidays in Cayos Zapatilla Price found within the past 48 hours. Click for updated prices. ![Las Americas Golden Tower Panama](https://images.trvl-media.com/lodging/10000000/9680000/9675300/9675263/83f7ceed_y.jpg?impolicy=fcrop&w=900&h=506&q=mediumHigh) ### Las Americas Golden Tower Panama San Francisco £622 per person 9 Jan - 13 Jan found 1 day ago Return direct flight included Newark Liberty Intl. Airport (EWR) to Panama City (PTY) 9/10 Wonderful! (1,009 reviews) Nice clean spacious room Reviewed on 1 Nov 2025 [](https://expedia.co.uk/go/package/search/FlightHotel/2026-01-09/2026-01-13/?FromAirport=EWR&Destination=PTY&NumRoom=1&NumAdult=2&NumChild=0&hotelId=9675263&paandie=true&dealMarker=5SCtZfXSGJnbEuuNfbozKTC5tWAmEBqUWdsm-Pj9DJKG7Ym9HG80AedgEw3XRhum) ![Central Hotel Panama Casco Viejo](https://images.trvl-media.com/lodging/16000000/15690000/15683600/15683502/3165768f_y.jpg?impolicy=fcrop&w=900&h=506&q=mediumHigh) ### Central Hotel Panama Casco Viejo Casco Viejo £754 per person 9 Jan - 13 Jan found 1 hour ago Return direct flight included Newark Liberty Intl. Airport (EWR) to Panama City (PTY) 9/10 Wonderful! (1,005 reviews) Staffs were wonderful. Reviewed on 28 Oct 2025 [](https://expedia.co.uk/go/package/search/FlightHotel/2026-01-09/2026-01-13/?FromAirport=EWR&Destination=PTY&NumRoom=1&NumAdult=2&NumChild=0&hotelId=15683502&paandie=true&dealMarker=9QQWmg7FEplEjIJhxEEjCFvIL9UroEIMEMuDyEkej-PEJZgFluPVFqW4cgLpy-fb) ![Dreams Playa Bonita Panama - All Inclusive](https://images.trvl-media.com/lodging/13000000/12450000/12445600/12445554/7c338453_y.jpg?impolicy=fcrop&w=900&h=506&q=mediumHigh) ### Dreams Playa Bonita Panama - All Inclusive £996 per person 9 Jan - 13 Jan found 1 hour ago Return direct flight included Newark Liberty Intl. Airport (EWR) to Panama City (PTY) 7.4/10 Good! (1,006 reviews) Great staff, room, amenities and property. Reviewed on 5 Nov 2025 [](https://expedia.co.uk/go/package/search/FlightHotel/2026-01-09/2026-01-13/?FromAirport=EWR&Destination=PTY&NumRoom=1&NumAdult=2&NumChild=0&hotelId=12445554&paandie=true&dealMarker=d8WXsIpRSRqP6I9NTyMJXuBgXamRjB1Tx8GZ9i2FTpgK7iRKD75y8QwgA8fBQDcj) Don't see what you're looking for? See all available trips from Newark Liberty Intl. Airport to Cayos Zapatilla [View all trips](https://expedia.co.uk/go/package/search/FlightHotel/2025-12-07/2025-12-14/?FromAirport=EWR&Destination=PAC&NumRoom=1&NumAdult=2&NumChild=0&paandie=true) ## More holidays you might like ![](https://forever.travel-assets.com/flex/flexmanager/images/2022/06/08/all-inclusive_holidays_US.jpeg?impolicy=fcrop&w=300&h=300&q=mediumHigh) All Inclusive Holidays [](https://expedia.co.uk/lp/theme-holidays/all-inclusive-holidays?rfrr=editorial.All_Inclusive%20Holidays.click) ![](https://forever.travel-assets.com/flex/flexmanager/images/2022/10/17/XPC_Beach_Overview_HR_v3.jpg?impolicy=fcrop&w=300&h=300&q=mediumHigh) Beach Holidays [](https://expedia.co.uk/lp/theme-holidays/beach-holidays?rfrr=editorial.Beach_Holidays.click) ![](https://forever.travel-assets.com/flex/flexmanager/images/2022/06/08/Family_holidays_US_3_.jpeg?impolicy=fcrop&w=300&h=300&q=mediumHigh) Family Friendly Holidays [](https://expedia.co.uk/lp/theme-holidays/kid-friendly-holidays?rfrr=editorial.Family_Friendly%20Holidays.click) ![](https://forever.travel-assets.com/flex/flexmanager/images/2022/04/29/frCA_Sejours_golf-Portugal.jpeg?impolicy=fcrop&w=300&h=300&q=mediumHigh) Golf Holidays [](https://expedia.co.uk/lp/theme-holidays/golf-holidays?rfrr=editorial.Golf_Holidays.click) ![](https://forever.travel-assets.com/flex/flexmanager/images/2022/07/15/US_Luxury_VR_Miami.jpg?impolicy=fcrop&w=300&h=300&q=mediumHigh) Luxury Holidays [](https://expedia.co.uk/lp/theme-holidays/luxury-holidays?rfrr=editorial.Luxury_Holidays.click) ![gay friendly holiday packages](https://forever.travel-assets.com/flex/flexmanager/images/2023/06/15/LGBTQIA_Holiday_Package.jpg?impolicy=fcrop&w=300&h=300&q=mediumHigh) LGBTQ+ Holidays [](https://expedia.co.uk/lp/theme-holidays/gay-friendly-holidays?rfrr=editorial.LGBTQ+_Holidays.click) ![](https://forever.travel-assets.com/flex/flexmanager/images/2022/08/29/romantic.jpg?impolicy=fcrop&w=300&h=300&q=mediumHigh) Romantic Holidays [](https://expedia.co.uk/lp/theme-holidays/romantic-holidays?rfrr=editorial.Romantic_Holidays.click) ![](https://forever.travel-assets.com/flex/flexmanager/images/2022/10/17/31952_v1_atfraraski22_insta_4.jpg?impolicy=fcrop&w=300&h=300&q=mediumHigh) Ski Holidays [](https://expedia.co.uk/lp/theme-holidays/ski-holidays?rfrr=editorial.Ski_Holidays.click) ![](https://forever.travel-assets.com/flex/flexmanager/images/2022/08/22/hero-image-pet-friendly_copy.jpg?impolicy=fcrop&w=300&h=300&q=mediumHigh) Pet Friendly Holidays [](https://expedia.co.uk/lp/theme-holidays/pet-friendly-holidays?rfrr=editorial.Pet_Friendly%20Holidays.click) ![](https://forever.travel-assets.com/flex/flexmanager/images/2023/05/10/mesog-34434-card-venice.jpg?impolicy=fcrop&w=300&h=300&q=mediumHigh) Where to go when [](https://expedia.co.uk/lp/b/where-to-go-when?rfrr=editorial.Where_to%20go%20when.click) ## More Holiday Ideas [Flights to Cayos Zapatilla](https://expedia.co.uk/Cheap-Flights-To-Cayos-Zapatilla.d6286134.Travel-Guide-Flights)[Cayos Zapatilla Hotels](https://expedia.co.uk/Cayos-Zapatilla-Hotels.d6286134.Travel-Guide-Hotels)[Cayos Zapatilla Holiday Rentals](https://expedia.co.uk/Cayos-Zapatilla-Holiday-Rentals.d6286134.Travel-Guide-HolidayRentals)[Cayos Zapatilla Car Hire](https://expedia.co.uk/Compare-Cheap-Car-Hire-In-Cayos-Zapatilla.d6286134.Car-Hire-Guide)[Cayos Zapatilla Holidays](https://expedia.co.uk/Cayos-Zapatilla.d6286134.Holidays-City-Breaks) \* Savings based on package bookings compared to the price of the same components booked separately. Savings not available on all packages. Flight-inclusive packages are ATOL protected. ![](https://a.travel-assets.com/mad-service/footer/bnaBanners/BEX_Footer.jpg) ## Go further with the Expedia app Save on select hotels when you book in the app. Our app deals help you to save on trips so you can travel more and manage it all on the go. Scan the QR code with your device camera and download our app ![QR code to download the app](data:image/png;base64,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)