Cheap Flights from Knoxville (TYS) to San Diego (SAN)

Featured airlines

    Plan, book, fly with confidence
    trending down icon
    Be in the know
    Get alerts if flight prices drop or rise*
    bex rewards loyalty icon
    Book smarter
    Save up to 25% on select hotels after you book a flight*
    payments icon
    Earn twice
    Earn your airline miles on top of our rewards
    Sign in
Flight from Knoxville to San Diego route information
Origin airport
McGhee Tyson
Destination airport
San Diego Intl.
Distance
3038 km

Compare flights from Knoxville to San Diego easily and book in confidence

For travelling on business or for pleasure, Expedia makes it easy to book your flights from Knoxville to San Diego. Operating between them flights per day, airlines cover the route. And fly direct, getting you to San Diego Intl. in just hours. If you have a preferred carrier, use our advanced search tool to find the right flight from McGhee Tyson to San Diego Intl..  

To make things even better, in the advanced search, you can also choose to fly economy, premium economy, business or first class, select your maximum number of stops, and pick your preferred departure and arrival time. You can also opt for refundable and direct flights. 

Grab a great deal on your flight from McGhee Tyson (TYS) to San Diego Intl. (SAN) 

The easiest way to view the best deals on flights from Knoxville to San Diego today is to enter your travel dates and hit search. From here, you can sort your results by price to see the cheapest flights first. Right now, return flights from McGhee Tyson to San Diego Intl. start at just and range up to .  

To find an even better deal, try  

  • being flexible on your dates – midweek flights can be cheaper
  • looking for other airports near Knoxville and San Diego
  • booking your flight during , the cheapest month on this route
  • varying your flight times – early morning and late at night are sometimes cheaper 

Why you should book your Knoxville to San Diego flight with Expedia!

We cater for all flight types, cabin classes and airlines. So whether you’re booking flights from McGhee Tyson to San Diego Intl. for a budget break or a business trip with a bit of pleasure thrown in, we make it easy to secure the seat that’s right for you.  

Thanks to our supersized inventory that offers great choice all in one place, you know you’ll get a great deal with Expedia. Especially if you bundle your flight together with your hotel, you will unlock amazing savings. For added peace of mind, you can choose flexible bookings or filter to find refundable options, so you won’t pay a fee to change your flight.  

Frequently asked questions

How much is a flight from TYS to San Diego Intl. Airport (SAN)?
The lowest price advertised for a round-trip journey from McGhee Tyson Airport (TYS) to San Diego Intl. Airport (SAN) is . But you better act fast. This figure is taken from fares listed within the last 7 days on Expedia for flights departing within the next year. Prices and availability are subject to change. Additional terms apply.
Do I need to pay a cancellation fee if I cancel my flight from TYS to San Diego Intl. Airport (SAN)?
We understand that things crop up unexpectedly, so we’ve made it as easy as possible for you to cancel your flight online. Just visit the Customer Service Portal and follow the instructions.
How do I find cheap flights from McGhee Tyson Airport (TYS) to San Diego Airport that have flexible change policies?
Many airlines offer the option to reschedule your flight without a change fee. All you pay is the difference between the original flight and the new flight. When you’re searching for Knoxville Airport to San Diego Intl. Airport (SAN) flights, you’ll see a “no change fees” filter for you to select.
How far is the flight from McGhee Tyson Airport (TYS) to San Diego Intl. Airport (SAN)?
Around 3,100 kilometres separates Alcoa and San Diego, so pack something to keep you occupied for a couple of hours. That gripping novel you’ve yet to start will do the trick.
Which airlines fly direct from Knoxville Airport to San Diego Intl. Airport (SAN)?
If you want to fly straight from McGhee Tyson Airport (TYS) to San Diego Airport, you’ll need to book a flight with one or more stops. Unfortunately, there aren’t any airlines that fly directly between these airports.
Are Knoxville Airport to San Diego Airport flight tickets cheaper when they're purchased at the last minute?
Fares from McGhee Tyson Airport (TYS) to San Diego Intl. Airport (SAN) are available up to 12 months prior to departure on Expedia. And although you may pick up a great last-minute deal, it’s not something you should count on. Also, booking your flights in advance means you’ll have more options — and you can avoid getting trapped in the dreaded middle seat! We regularly update our fares to bring you the best bargains, so check back often for all the latest specials.
*Available to Expedia members.