£408 Cheap Flights from Panama City (PTY) to Johannesburg (JNB)

View £408 flight on Sun, 19 Jul 2026Opens in a new window

Popular airlines from Tocumen Intl. Airport (PTY) to O.R. Tambo Intl. Airport (JNB)

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Cheap Flights from Panama City (PTY) to Johannesburg (JNB)

Prices were available within the past 7 days and start at £408 for one-way flights and £701 for round trip, for the period specified. Prices and availability are subject to change. Additional terms apply.

Lufthansa
Tue, 2 Feb - Wed, 17 Feb
PTY
Panama City
JNB
Johannesburg
£701 Return, found 2 days ago
£701
Return
found 2 days ago
Select Lufthansa flight, departing Tue, 2 Feb from Panama City to Johannesburg, returning Wed, 17 Feb, priced at £701 found 2 days ago
Lufthansa
Tue, 2 Feb - Tue, 16 Feb
PTY
Panama City
JNB
Johannesburg
£951 Return, found 2 days ago
£951
Return
found 2 days ago
Select Lufthansa flight, departing Tue, 2 Feb from Panama City to Johannesburg, returning Tue, 16 Feb, priced at £951 found 2 days ago
Lufthansa
Sat, 6 Feb - Sun, 21 Feb
PTY
Panama City
JNB
Johannesburg
£986 Return, found 2 days ago
£986
Return
found 2 days ago
Select Lufthansa flight, departing Sat, 6 Feb from Panama City to Johannesburg, returning Sun, 21 Feb, priced at £986 found 2 days ago
Lufthansa
Tue, 2 Feb - Tue, 16 Feb
PTY
Panama City
JNB
Johannesburg
£1,050 Return, found 2 days ago
£1,050
Return
found 2 days ago
Select Lufthansa flight, departing Tue, 2 Feb from Panama City to Johannesburg, returning Tue, 16 Feb, priced at £1,050 found 2 days ago
Air Europa
Tue, 2 Feb - Tue, 16 Feb
PTY
Panama City
JNB
Johannesburg
£1,110 Return, found 2 days ago
£1,110
Return
found 2 days ago
Select Air Europa flight, departing Tue, 2 Feb from Panama City to Johannesburg, returning Tue, 16 Feb, priced at £1,110 found 2 days ago
Lufthansa
Tue, 2 Feb - Wed, 17 Feb
PTY
Panama City
JNB
Johannesburg
£1,154 Return, found 2 days ago
£1,154
Return
found 2 days ago
Select Lufthansa flight, departing Tue, 2 Feb from Panama City to Johannesburg, returning Wed, 17 Feb, priced at £1,154 found 2 days ago
Lufthansa
Sat, 6 Feb - Sun, 21 Feb
PTY
Panama City
JNB
Johannesburg
£1,169 Return, found 2 days ago
£1,169
Return
found 2 days ago
Select Lufthansa flight, departing Sat, 6 Feb from Panama City to Johannesburg, returning Sun, 21 Feb, priced at £1,169 found 2 days ago
Copa
Tue, 2 Feb - Tue, 16 Feb
PTY
Panama City
JNB
Johannesburg
£1,197 Return, found 2 days ago
£1,197
Return
found 2 days ago
Select Copa flight, departing Tue, 2 Feb from Panama City to Johannesburg, returning Tue, 16 Feb, priced at £1,197 found 2 days ago
KLM
Sat, 6 Feb - Sun, 21 Feb
PTY
Panama City
JNB
Johannesburg
£1,549 Return, found 2 days ago
£1,549
Return
found 2 days ago
Select KLM flight, departing Sat, 6 Feb from Panama City to Johannesburg, returning Sun, 21 Feb, priced at £1,549 found 2 days ago
Air France
Tue, 2 Feb - Tue, 16 Feb
PTY
Panama City
JNB
Johannesburg
£1,571 Return, found 2 days ago
£1,571
Return
found 2 days ago
Select Air France flight, departing Tue, 2 Feb from Panama City to Johannesburg, returning Tue, 16 Feb, priced at £1,571 found 2 days ago

Frequently asked questions

How much does a flight from Panama City (PTY-Tocumen Intl.) to Johannesburg (JNB-O.R. Tambo Intl.) cost?
One-way flights typically cost between £756 and £6,523 and return flights often range between £756 and £6,523. Flight prices vary based on the month and day of the week you want to travel, as well as the airline and how far in advance you book your ticket. Filter your search on Expedia by "Price (lowest to highest)" to see the cheapest fares first, and use the Price Tracking tool to receive alerts when Anaa (AAA) to Toronto, ON (YYZ-Pearson Intl.) ticket fares go up or down.
How do I find cheap flights from Panama City (PTY-Tocumen Intl.) to Johannesburg (JNB-O.R. Tambo Intl.)?
To find a cheap flight from Panama City (PTY-Tocumen Intl.) to Johannesburg (JNB-O.R. Tambo Intl.), be flexible with your dates. Traveling outside of peak vacation months and booking a mid-week flight can help you save. Early morning and late night flights are often more affordable, too. Expedia allows you to compare flight times, airlines and routes all in one place to find low fares. You can also set up Price Tracking and receive alerts when fares go up or down.
What is the best time to fly from Panama City (PTY-Tocumen Intl.) to Johannesburg (JNB-O.R. Tambo Intl.)?
The best time to fly is usually mid-week (Tuesday or Wednesday) and during early morning hours as flights tend to be cheaper, less crowded, and generally more on-time. Avoid major holidays and peak vacation seasons for smoother travel. Combining off-peak days and hours often gives the best combination of cost, comfort, and convenience.
How many flights per day from Panama City (PTY-Tocumen Intl.) to Johannesburg (JNB-O.R. Tambo Intl.)?
There are approximately 16 connecting flights per day from Panama City (PTY-Tocumen Intl.) to Johannesburg (JNB-O.R. Tambo Intl.). Some common connection points include Schiphol (AMS), Adolfo Suarez Madrid-Barajas (MAD), and George Bush Intercontinental (IAH).
What is the earliest flight from Panama City (PTY-Tocumen Intl.) to Johannesburg (JNB-O.R. Tambo Intl.)?
The earliest flight from Panama City (PTY-Tocumen Intl.) to Johannesburg (JNB-O.R. Tambo Intl.) typically departs at approximately 2:55 AM local time. This is a seasonal service, active only in February, and is operated by AV and 5K. An early departure like this can help you maximise your time at your destination. To compare early flights on Expedia, select the "Early Morning" and "Morning" filters in your search.
What day of the week has the most flights from Panama City (PTY-Tocumen Intl.) to Johannesburg (JNB-O.R. Tambo Intl.)?
You'll typically find the most flights from Panama City (PTY-Tocumen Intl.) to Johannesburg (JNB-O.R. Tambo Intl.) on a Tuesday, with around 37 flights available. This gives you a good selection of options for your journey. Major airlines on this route include Copa Airlines, United Airlines, and American Airlines. Compared to other days, Tuesdays offer notably more flight options.
What are the most popular departure times for flights from Panama City (PTY-Tocumen Intl.) to Johannesburg (JNB-O.R. Tambo Intl.)?
The most popular departure times for flights from Panama City (PTY-Tocumen Intl.) to Johannesburg (JNB-O.R. Tambo Intl.) are in the morning, from 9am to 12pm. About 62% of passengers prefer this time. Many major carriers, including United Airlines, Copa and Lufthansa, offer flights during this window. This timing works well because it allows you to start your journey relatively early in the day, giving you more flexibility upon arrival.
How long does it take to fly from Panama City (PTY-Tocumen Intl.) to Johannesburg (JNB-O.R. Tambo Intl.)?
Flying from PTY to JNB with a connection usually takes about 22 hours 20 minutes, traveling roughly 7,583 miles. Keep in mind that actual flight times can vary due to wind patterns, weather, and air traffic.
Can you fly business or first class from Panama City (PTY-Tocumen Intl.) to Johannesburg (JNB-O.R. Tambo Intl.)?
Select the "Business class" and "First class" filters when looking for PTY to JNB flights on Expedia. This is the easiest way to compare prices, routes and flight times for your trip.
How do I earn miles on a Panama City (PTY-Tocumen Intl.) to Johannesburg (JNB-O.R. Tambo Intl.) flight with Expedia?
It's easy to earn miles on a Panama City (PTY-Tocumen Intl.) to Johannesburg (JNB-O.R. Tambo Intl.) flight when you book with Expedia. Before you confirm your booking, simply select your frequent flyer program and enter your program number. As a member of One Key™, you can also earn OneKeyCash™* on top of your airline miles when you book with Expedia. *Excludes taxes and fees. OneKeyCash is not redeemable for cash and can only be used on Expedia and other participating brands.
What airports do you fly into for Johannesburg from Tocumen Intl. (PTY)?
From Tocumen Intl. (PTY), you can fly directly into O.R. Tambo Intl. (JNB) to reach Johannesburg. Some flights may connect through major hubs like Schiphol (AMS), Orlando Intl. (MCO), Washington Dulles Intl. (IAD) before reaching Johannesburg. Compare routes and airports on Expedia to find the best flight options for your travel plans.
Is it cheaper to buy a plane ticket from Panama City (PTY-Tocumen Intl.) to Johannesburg (JNB-O.R. Tambo Intl.) at the last minute?
Typically, booking a last minute flight from Panama City (PTY-Tocumen Intl.) to Johannesburg (JNB-O.R. Tambo Intl.) will be more expensive than booking in advance. As the departure date approaches, there are usually fewer seats available which can drive up the cost. However, if there's some wiggle room with your travel dates and times, you could bag a cheap last-minute fare.
Is it cheaper to book a Panama City (PTY-Tocumen Intl.) to Johannesburg (JNB-O.R. Tambo Intl.) flight and hotel package?
Securing a Panama City (PTY-Tocumen Intl.) to Johannesburg (JNB-O.R. Tambo Intl.) flight and hotel package is usually cheaper than booking separately. With Expedia, you can enjoy the ease of organizing your travels all in one place. Select from our extensive range of stays and then add flights, activities and car rentals to your booking. Bundle everything together, and you could save hundreds of dollars.
Can I cancel or change the date of my flight from Panama City (PTY-Tocumen Intl.) to Johannesburg (JNB-O.R. Tambo Intl.)?
If you booked your Panama City (PTY-Tocumen Intl.) to Johannesburg (JNB-O.R. Tambo Intl.) flight within the last 24 hours, you may be able to modify or cancel it without any fees. Depending on the airline and the type of ticket you have, additional charges may apply for changes beyond this timeframe. Airline policies and contact information can be found in your itinerary or confirmation email. Or, head to our Customer Service portal if you'd like more information.

Travel information

Origin airport
Tocumen Intl.
Destination airport
O.R. Tambo Intl.
Return price
£700
Distance
12131 km

Book with confidence

Compare flights from Panama City to Johannesburg easily and book with confidence

For travelling on business or for pleasure, Expedia makes it easy to book your flights from Panama City to Johannesburg. Operating between them flights per day, 20 airlines cover the route. And fly direct, getting you to O.R. Tambo Intl. in just hours. If you have a preferred carrier, use our advanced search tool to find the right flight from Tocumen Intl. to O.R. Tambo Intl..  

To make things even better, in the advanced search, you can also choose to fly economy, premium economy, business or first class, select your maximum number of stops, and pick your preferred departure and arrival time. You can also opt for refundable and direct flights. 

Grab a great deal on your flight from Tocumen Intl. (PTY) to O.R. Tambo Intl. (JNB)

The easiest way to view the best deals on flights from Panama City to Johannesburg today is to enter your travel dates and hit search. From here, you can sort your results by price to see the cheapest flights first. Right now, return flights from Tocumen Intl. to O.R. Tambo Intl. start at just £701 and range up to £1,571.  

To find an even better deal, try  

  • being flexible on your dates – midweek flights can be cheaper
  • looking for other airports near Panama City and Johannesburg
  • booking your flight during February, the cheapest month on this route
  • varying your flight times – early morning and late at night are sometimes cheaper 

Why you should book your Panama City to Johannesburg flight with Expedia!

We cater for all flight types, cabin classes and airlines. So whether you’re booking flights from Tocumen Intl. to O.R. Tambo Intl. for a budget break or a business trip with a bit of pleasure thrown in, we make it easy to secure the seat that’s right for you.  

Thanks to our supersized inventory that offers great choice all in one place, you know you’ll get a great deal with Expedia. Especially if you bundle your flight together with your hotel, you will unlock amazing savings. For added peace of mind, you can choose flexible bookings or filter to find refundable options, so you won’t pay a fee to change your flight.  

Compare flights from Panama City to Johannesburg easily and book with confidence

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