Title: The Best Hotels Closest to UCSF Mission Bay in San Francisco - 2026 Updated Prices | Expedia.co.uk [Downtown San Francisco Travel Guide](https://expedia.co.uk/San-Francisco-Downtown-San-Francisco.dx6151902)[UCSF Mission Bay Car Hire](https://expedia.co.uk/Compare-Cheap-Car-Hire-In-UCSF-Mission-Bay.d553248635389801411.Car-Hire-Guide)[UCSF Mission Bay Holidays](https://expedia.co.uk/UCSF-Mission-Bay-Downtown-San-Francisco.d553248635389801411.Attraction) ![Lodging Image](https://a.travel-assets.com/travel-assets-manager/bex-affinities/lodging.jpg?impolicy=fcrop&w=1200&h=500&q=medium) ![](https://a.travel-assets.com/travel-assets-manager/bex-affinities/lodging.jpg?impolicy=fcrop&w=1200&h=500&q=medium) - ![](https://a.travel-assets.com/travel-assets-manager/pictogram-bex/light__price_find.svg) ### Change your mind Book hotels with free cancellation - ![](https://a.travel-assets.com/travel-assets-manager/pictogram-bex/light__deals.svg) ### Treat yourself Save instantly and earn perks with One Key [Learn about One Key](https://www.expedia.co.uk/welcome-one-key) - ![](https://a.travel-assets.com/travel-assets-manager/pictogram-bex/light__bed.svg) ### Be picky Search almost a million properties worldwide ## Check prices for these dates Tonight [28 Mar - 29 Mar](https://www.expedia.co.uk/Hotel-Search?regionId=553248635389801411&startDate=2026-03-28&endDate=2026-03-29&adults=2&rfrr=TG.LP.CheckPrices.Hotel&openPlayBack=true) Tomorrow [29 Mar - 30 Mar](https://www.expedia.co.uk/Hotel-Search?regionId=553248635389801411&startDate=2026-03-29&endDate=2026-03-30&adults=2&rfrr=TG.LP.CheckPrices.Hotel&openPlayBack=true) Next weekend [3 Apr - 5 Apr](https://www.expedia.co.uk/Hotel-Search?regionId=553248635389801411&startDate=2026-04-03&endDate=2026-04-05&adults=2&rfrr=TG.LP.CheckPrices.Hotel&openPlayBack=true) In two weeks [10 Apr - 12 Apr](https://www.expedia.co.uk/Hotel-Search?regionId=553248635389801411&startDate=2026-04-10&endDate=2026-04-12&adults=2&rfrr=TG.LP.CheckPrices.Hotel&openPlayBack=true) Recommended Price (low to high) Distance Property class ## Our top choices for UCSF Mission Bay hotels ![Coffee shop](https://images.trvl-media.com/lodging/71000000/70100000/70097200/70097106/7985eb30.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![View from room](https://images.trvl-media.com/lodging/71000000/70100000/70097200/70097106/3bc0e86d.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Reception](https://images.trvl-media.com/lodging/71000000/70100000/70097200/70097106/c2578b6d.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Exterior](https://images.trvl-media.com/lodging/71000000/70100000/70097200/70097106/f72650f9.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ### LUMA Hotel San Francisco [](https://www.expedia.co.uk/San-Francisco-Hotels-LUMA-Hotel-San-Francisco.h70097106.Hotel-Information) 0.4 mi from UCSF Mission Bay 9.6/10 Exceptional (2,425 reviews) "Excellent hotel " ![United States](https://a.travel-assets.com/egds/marks/flags/us.svg) Alexis £194 includes taxes & fees 2 Apr - 3 Apr [](https://www.expedia.co.uk/San-Francisco-Hotels-LUMA-Hotel-San-Francisco.h70097106.Hotel-Information) ![Terrace/patio](https://images.trvl-media.com/lodging/32000000/31420000/31419900/31419890/91986f78.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Hypo-allergenic bedding, desk, laptop workspace, blackout curtains](https://images.trvl-media.com/lodging/32000000/31420000/31419900/31419890/b089b5be.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Lobby](https://images.trvl-media.com/lodging/32000000/31420000/31419900/31419890/6945eefa.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Daily buffet breakfast (USD 16 per person)](https://images.trvl-media.com/lodging/32000000/31420000/31419900/31419890/f9d4387a.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ### Hyatt Place San Francisco Downtown [](https://www.expedia.co.uk/San-Francisco-Hotels-Hyatt-Place-San-Francisco-Downtown.h31419890.Hotel-Information) 0.7 mi from UCSF Mission Bay 9.4/10 Exceptional (2,066 reviews) "Wonderful stay!" ![United States](https://a.travel-assets.com/egds/marks/flags/us.svg) Lauren £177 includes taxes & fees 5 Apr - 6 Apr [](https://www.expedia.co.uk/San-Francisco-Hotels-Hyatt-Place-San-Francisco-Downtown.h31419890.Hotel-Information) ![Property entrance](https://images.trvl-media.com/lodging/17000000/16820000/16819700/16819669/004f15cd.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Suite, 1 King Bed, Park View | Premium bedding, in-room safe, desk, blackout curtains](https://images.trvl-media.com/lodging/17000000/16820000/16819700/16819669/3c515aa8.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Lobby](https://images.trvl-media.com/lodging/17000000/16820000/16819700/16819669/4f46bfa5.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Interior detail](https://images.trvl-media.com/lodging/17000000/16820000/16819700/16819669/e4464a9a.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ### Hotel VIA [](https://www.expedia.co.uk/San-Francisco-Hotels-Hotel-VIA.h16819669.Hotel-Information) 0.7 mi from UCSF Mission Bay 9.2/10 Wonderful (1,527 reviews) "The rooms were clean and perfect for my stay! Would stay at this hotel again!" ![United States](https://a.travel-assets.com/egds/marks/flags/us.svg) Sofia Mae £166 includes taxes & fees 18 Apr - 19 Apr [](https://www.expedia.co.uk/San-Francisco-Hotels-Hotel-VIA.h16819669.Hotel-Information) ![Lobby](https://images.trvl-media.com/lodging/1000000/30000/22400/22303/e828523b.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Lobby](https://images.trvl-media.com/lodging/1000000/30000/22400/22303/1c7bba41.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Lobby](https://images.trvl-media.com/lodging/1000000/30000/22400/22303/743c2165.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Exterior](https://images.trvl-media.com/lodging/1000000/30000/22400/22303/73a80e55.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ### Galleria Park Hotel [](https://www.expedia.co.uk/San-Francisco-Hotels-Galleria-Park-Hotel.h22303.Hotel-Information) Financial District, 1.6 mi from UCSF Mission Bay 9.6/10 Exceptional (1,003 reviews) "Clean rooms, friendly staff and wonderful location " ![United States](https://a.travel-assets.com/egds/marks/flags/us.svg) Alejandro £149 includes taxes & fees 5 Apr - 6 Apr [](https://www.expedia.co.uk/San-Francisco-Hotels-Galleria-Park-Hotel.h22303.Hotel-Information) ![Exterior](https://images.trvl-media.com/lodging/1000000/10000/500/491/c9a2355d.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Club Room, 1 King Bed | Hypo-allergenic bedding, down duvets, in-room safe, desk](https://images.trvl-media.com/lodging/1000000/10000/500/491/9b875e1e.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Presidential Suite, 1 Bedroom | Living area | 55-inch flat-screen TV with cable channels, TV, pay films](https://images.trvl-media.com/lodging/1000000/10000/500/491/14a438d3.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Exterior](https://images.trvl-media.com/lodging/1000000/10000/500/491/fa08aa94.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ### Hyatt Regency San Francisco Downtown SOMA [](https://www.expedia.co.uk/San-Francisco-Hotels-The-Park-Central-San-Francisco-Hyatt-Affiliated-Hotel.h491.Hotel-Information) South of Market, 1.4 mi from UCSF Mission Bay 9.4/10 Exceptional (1,283 reviews) "Enjoyed our stay , very clean and view was amazing! Our Suite was perfect!" ![United States](https://a.travel-assets.com/egds/marks/flags/us.svg) diana l £171 includes taxes & fees 24 Apr - 25 Apr [](https://www.expedia.co.uk/San-Francisco-Hotels-The-Park-Central-San-Francisco-Hyatt-Affiliated-Hotel.h491.Hotel-Information) ![3 bars/lounges](https://images.trvl-media.com/lodging/28000000/27120000/27110600/27110513/abad6cd0.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Reception](https://images.trvl-media.com/lodging/28000000/27120000/27110600/27110513/5931a034.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Exterior](https://images.trvl-media.com/lodging/28000000/27120000/27110600/27110513/04a59767.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Suite, 1 King Bed, Fireplace (Landmark View) | Living area | 55-inch Smart TV with satellite channels, TV, Netflix](https://images.trvl-media.com/lodging/28000000/27120000/27110600/27110513/3012b8f0.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ### Canopy by Hilton San Francisco SoMa [](https://www.expedia.co.uk/San-Francisco-Hotels-Canopy-By-Hilton-San-Francisco-SoMa.h27110513.Hotel-Information) South Park, 1.1 mi from UCSF Mission Bay 9.0/10 Wonderful (1,000 reviews) "Brought our pup with us and had a great stay. Restaurants nearby. Would stay again." ![United States](https://a.travel-assets.com/egds/marks/flags/us.svg) Marcia £150 includes taxes & fees 11 Apr - 12 Apr [](https://www.expedia.co.uk/San-Francisco-Hotels-Canopy-By-Hilton-San-Francisco-SoMa.h27110513.Hotel-Information) ![Premium bedding, in-room safe, desk, laptop workspace](https://images.trvl-media.com/lodging/2000000/1770000/1766700/1766605/7856c00e.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Meeting facility](https://images.trvl-media.com/lodging/2000000/1770000/1766700/1766605/da85ef17.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Premium bedding, in-room safe, desk, laptop workspace](https://images.trvl-media.com/lodging/2000000/1770000/1766700/1766605/f7c5f6c0.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Room amenity](https://images.trvl-media.com/lodging/2000000/1770000/1766700/1766605/5517eff5.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ### InterContinental San Francisco by IHG [](https://www.expedia.co.uk/San-Francisco-Hotels-InterContinental-San-Francisco.h1766605.Hotel-Information) South of Market, 1.1 mi from UCSF Mission Bay 9.2/10 Wonderful (1,090 reviews) "Second time staying here due to close proximity to Moscone West. I slept very well and definitely will be back. " ![United States](https://a.travel-assets.com/egds/marks/flags/us.svg) Devyn £214 includes taxes & fees 24 Apr - 25 Apr [](https://www.expedia.co.uk/San-Francisco-Hotels-InterContinental-San-Francisco.h1766605.Hotel-Information) ![Daily buffet breakfast (USD 22.50 per person)](https://images.trvl-media.com/lodging/70000000/69560000/69551600/69551553/w5519h4629x0y0-614e04d9.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Lobby](https://images.trvl-media.com/lodging/70000000/69560000/69551600/69551553/1ab366ae.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![View from property](https://images.trvl-media.com/lodging/70000000/69560000/69551600/69551553/cadb58e5.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Room, 1 King Bed (High Floor) | Premium bedding, pillow-top beds, in-room safe, desk](https://images.trvl-media.com/lodging/70000000/69560000/69551600/69551553/4835e3a9.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ### citizenM San Francisco Union Square [](https://www.expedia.co.uk/San-Francisco-Hotels-CitizenM-San-Francisco-Union-Square.h69551553.Hotel-Information) Union Square, 1.4 mi from UCSF Mission Bay 9.4/10 Exceptional (1,457 reviews) "amazing stay perfect home away from home " ![United States](https://a.travel-assets.com/egds/marks/flags/us.svg) Yvette £118 includes taxes & fees 5 Apr - 6 Apr [](https://www.expedia.co.uk/San-Francisco-Hotels-CitizenM-San-Francisco-Union-Square.h69551553.Hotel-Information) ![Property entrance](https://images.trvl-media.com/lodging/2000000/1520000/1516000/1515923/72e31d9d.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Bar (on property)](https://images.trvl-media.com/lodging/2000000/1520000/1516000/1515923/d07a1e26.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Room, 1 King Bed, Terrace | Premium bedding, down duvets, pillow-top beds, in-room safe](https://images.trvl-media.com/lodging/2000000/1520000/1516000/1515923/63c9cbdc.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Lobby sitting area](https://images.trvl-media.com/lodging/2000000/1520000/1516000/1515923/ed3ae5f9.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ### Orchard Garden Hotel [](https://www.expedia.co.uk/San-Francisco-Hotels-Orchard-Garden-Hotel.h1515923.Hotel-Information) Chinatown, 1.7 mi from UCSF Mission Bay 9.6/10 Exceptional (1,003 reviews) "Clean, fast check in, convenient location" ![United States](https://a.travel-assets.com/egds/marks/flags/us.svg) TANYA £127 includes taxes & fees 10 Apr - 11 Apr [](https://www.expedia.co.uk/San-Francisco-Hotels-Orchard-Garden-Hotel.h1515923.Hotel-Information) ![Exterior](https://images.trvl-media.com/lodging/2000000/1330000/1322000/1321986/a5681857.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Presidential Suite, 1 Bedroom | Frette Italian sheets, premium bedding, down duvets, pillow-top beds](https://images.trvl-media.com/lodging/2000000/1330000/1322000/1321986/45abbb57.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Indoor pool](https://images.trvl-media.com/lodging/2000000/1330000/1322000/1321986/w4000h2662x0y0-41a38e25.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Suite, 1 Bedroom, Corner | Frette Italian sheets, premium bedding, down duvets, pillow-top beds](https://images.trvl-media.com/lodging/2000000/1330000/1322000/1321986/29f2f698.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ### The St. Regis San Francisco [](https://www.expedia.co.uk/San-Francisco-Hotels-The-St-Regis-San-Francisco.h1321986.Hotel-Information) South of Market, 1.3 mi from UCSF Mission Bay 9.4/10 Exceptional (715 reviews) "The hotel staff was so welcoming and took extra care of our two children by bringing surprise cookies and milk to the room, kid size spa robes and slippers and gifts upon checkout. The food at Astra was delicious and the indoor pool was so much fun. " ![United States](https://a.travel-assets.com/egds/marks/flags/us.svg) Margeaux £369 includes taxes & fees 10 Apr - 11 Apr [](https://www.expedia.co.uk/San-Francisco-Hotels-The-St-Regis-San-Francisco.h1321986.Hotel-Information) ![Lobby](https://images.trvl-media.com/lodging/1000000/700000/693700/693658/69c56718.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Hypo-allergenic bedding, in-room safe, desk, laptop workspace](https://images.trvl-media.com/lodging/1000000/700000/693700/693658/100ffc4f.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Courtyard](https://images.trvl-media.com/lodging/1000000/700000/693700/693658/e282d47e.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Front of property](https://images.trvl-media.com/lodging/1000000/700000/693700/693658/1656ff5c.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ### The Clancy, Autograph Collection by Marriott [](https://www.expedia.co.uk/San-Francisco-Hotels-The-Clancy.h693658.Hotel-Information) South Park, 1.2 mi from UCSF Mission Bay 9.2/10 Wonderful (1,001 reviews) "Great location, friendly staff, rooms larger than the typical SF postage stamp " ![United States](https://a.travel-assets.com/egds/marks/flags/us.svg) Tricia £176 includes taxes & fees 25 Apr - 26 Apr [](https://www.expedia.co.uk/San-Francisco-Hotels-The-Clancy.h693658.Hotel-Information) ![Indoor pool](https://images.trvl-media.com/lodging/1000000/30000/23500/23406/b53af55a.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Executive lounge](https://images.trvl-media.com/lodging/1000000/30000/23500/23406/b267e1c4.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Exterior](https://images.trvl-media.com/lodging/1000000/30000/23500/23406/c1d68595.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Lobby sitting area](https://images.trvl-media.com/lodging/1000000/30000/23500/23406/01ffa11d.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ### Hotel Nikko San Francisco [](https://www.expedia.co.uk/San-Francisco-Hotels-Hotel-Nikko-San-Francisco.h23406.Hotel-Information) Union Square, 1.5 mi from UCSF Mission Bay 9.4/10 Exceptional (2,811 reviews) "The hotel was clean and the staff was incredible. " ![United States](https://a.travel-assets.com/egds/marks/flags/us.svg) Jake £192 includes taxes & fees 10 Apr - 11 Apr [](https://www.expedia.co.uk/San-Francisco-Hotels-Hotel-Nikko-San-Francisco.h23406.Hotel-Information) ![Lobby sitting area](https://images.trvl-media.com/lodging/1000000/30000/20600/20547/944f985c.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Property entrance](https://images.trvl-media.com/lodging/1000000/30000/20600/20547/17458474.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Bar (on property)](https://images.trvl-media.com/lodging/1000000/30000/20600/20547/d2ce10c0.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![In-room safe, desk, blackout curtains, iron/ironing board](https://images.trvl-media.com/lodging/1000000/30000/20600/20547/aff7fa14.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ### Chancellor Hotel on Union Square [](https://www.expedia.co.uk/San-Francisco-Hotels-Chancellor-Hotel-On-Union-Square.h20547.Hotel-Information) 1.6 mi from UCSF Mission Bay 9.4/10 Exceptional (3,221 reviews) "Good location very friendly staff old style hotel maintained well " ![United Kingdom](https://a.travel-assets.com/egds/marks/flags/uk.svg) Jonathan £95 includes taxes & fees 29 Mar - 30 Mar [](https://www.expedia.co.uk/San-Francisco-Hotels-Chancellor-Hotel-On-Union-Square.h20547.Hotel-Information) ![Terrace/patio](https://images.trvl-media.com/lodging/1000000/800000/791800/791769/bff475ef.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Exterior](https://images.trvl-media.com/lodging/1000000/800000/791800/791769/ab6ff173.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Premium bedding, down duvets, minibar, in-room safe](https://images.trvl-media.com/lodging/1000000/800000/791800/791769/bd897e6b.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Serves breakfast, lunch and dinner](https://images.trvl-media.com/lodging/1000000/800000/791800/791769/0cd41feb.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ### Four Seasons Hotel San Francisco [](https://www.expedia.co.uk/San-Francisco-Hotels-Four-Seasons-Hotel-San-Francisco.h791769.Hotel-Information) South of Market, 1.4 mi from UCSF Mission Bay 9.4/10 Exceptional (1,000 reviews) " Excellent rooms and staff, terrific food, great location " ![United States](https://a.travel-assets.com/egds/marks/flags/us.svg) Roberta £417 includes taxes & fees 4 Apr - 5 Apr [](https://www.expedia.co.uk/San-Francisco-Hotels-Four-Seasons-Hotel-San-Francisco.h791769.Hotel-Information) ![Exterior](https://images.trvl-media.com/lodging/1000000/290000/287200/287112/7fe7eb3b.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Property amenity](https://images.trvl-media.com/lodging/1000000/290000/287200/287112/f11ecdc1.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Flat-screen TV, pay films, MP3 dock](https://images.trvl-media.com/lodging/1000000/290000/287200/287112/0c9770db.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Penthouse, 1 Bedroom, City View | Living room | Flat-screen TV, pay films, MP3 dock](https://images.trvl-media.com/lodging/1000000/290000/287200/287112/3afd96af.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ### W San Francisco [](https://www.expedia.co.uk/San-Francisco-Hotels-W-San-Francisco.h287112.Hotel-Information) South Park, 1.2 mi from UCSF Mission Bay 9.0/10 Wonderful (1,002 reviews) "Everyone was very nice" ![United States](https://a.travel-assets.com/egds/marks/flags/us.svg) Matthew £184 includes taxes & fees 5 Apr - 6 Apr [](https://www.expedia.co.uk/San-Francisco-Hotels-W-San-Francisco.h287112.Hotel-Information) ![View from property](https://images.trvl-media.com/lodging/1000000/30000/27300/27274/w4000h2663x0y0-df4f3756.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![View from property](https://images.trvl-media.com/lodging/1000000/30000/27300/27274/189643db.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Lobby](https://images.trvl-media.com/lodging/1000000/30000/27300/27274/59a0fd33.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Lobby](https://images.trvl-media.com/lodging/1000000/30000/27300/27274/e72fe89a.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ### Palace Hotel, a Luxury Collection Hotel, San Francisco [](https://www.expedia.co.uk/San-Francisco-Hotels-Palace-Hotel.h27274.Hotel-Information) Financial District, 1.4 mi from UCSF Mission Bay 9.2/10 Wonderful (1,001 reviews) "Wonderful stay! We loved it!" ![United States](https://a.travel-assets.com/egds/marks/flags/us.svg) Sara £263 includes taxes & fees 10 Apr - 11 Apr [](https://www.expedia.co.uk/San-Francisco-Hotels-Palace-Hotel.h27274.Hotel-Information) ![Bar (on property)](https://images.trvl-media.com/lodging/1000000/230000/225900/225819/48cf15fe.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Junior Suite, 1 King Bed, City View, Corner | Premium bedding, in-room safe, desk, blackout curtains](https://images.trvl-media.com/lodging/1000000/230000/225900/225819/94c0b9bd.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Daily full breakfast for a fee](https://images.trvl-media.com/lodging/1000000/230000/225900/225819/84c87d37.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Breakfast and dinner served](https://images.trvl-media.com/lodging/1000000/230000/225900/225819/b5cc10dd.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ### Hotel Zelos San Francisco [](https://www.expedia.co.uk/San-Francisco-Hotels-Hotel-Zelos-San-Francisco.h225819.Hotel-Information) South of Market, 1.4 mi from UCSF Mission Bay 9.0/10 Wonderful (1,135 reviews) "Great rooms and ambiance, it is also a block from the train terminus for SFO airport. " ![Canada](https://a.travel-assets.com/egds/marks/flags/ca.svg) Peter £164 includes taxes & fees 11 Apr - 12 Apr [](https://www.expedia.co.uk/San-Francisco-Hotels-Hotel-Zelos-San-Francisco.h225819.Hotel-Information) ![Restaurant](https://images.trvl-media.com/lodging/1000000/30000/24600/24540/75e58d80.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Studio Suite, 1 King Bed | Premium bedding, pillow-top beds, in-room safe, desk](https://images.trvl-media.com/lodging/1000000/30000/24600/24540/a689a8ce.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Exterior](https://images.trvl-media.com/lodging/1000000/30000/24600/24540/9ee74e51.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Interior entrance](https://images.trvl-media.com/lodging/1000000/30000/24600/24540/ebf8a29f.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ### Hotel G San Francisco [](https://www.expedia.co.uk/San-Francisco-Hotels-Hotel-G-San-Francisco.h24540.Hotel-Information) 1.6 mi from UCSF Mission Bay 9.2/10 Wonderful (1,005 reviews) "My stay was great I liked how the house keeping was so diligent about cleaning the rooms.My stay was wonderful " ![United States](https://a.travel-assets.com/egds/marks/flags/us.svg) Theodore £135 includes taxes & fees 26 Apr - 27 Apr [](https://www.expedia.co.uk/San-Francisco-Hotels-Hotel-G-San-Francisco.h24540.Hotel-Information) ![Lobby sitting area](https://images.trvl-media.com/lodging/1000000/20000/15800/15769/a6ba3784.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Property entrance](https://images.trvl-media.com/lodging/1000000/20000/15800/15769/105e4279.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Interior entrance](https://images.trvl-media.com/lodging/1000000/20000/15800/15769/33ce2394.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Fireplace](https://images.trvl-media.com/lodging/1000000/20000/15800/15769/b8c723b6.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ### The Marker Union Square San Francisco [](https://www.expedia.co.uk/San-Francisco-Hotels-The-Marker-San-Francisco.h15769.Hotel-Information) 1.6 mi from UCSF Mission Bay 9.2/10 Wonderful (1,191 reviews) "great hotel " ![United States](https://a.travel-assets.com/egds/marks/flags/us.svg) Lorena £145 includes taxes & fees 12 Apr - 13 Apr [](https://www.expedia.co.uk/San-Francisco-Hotels-The-Marker-San-Francisco.h15769.Hotel-Information) ![Lobby](https://images.trvl-media.com/lodging/1000000/20000/15300/15254/6f8c6b2f.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Restaurant](https://images.trvl-media.com/lodging/1000000/20000/15300/15254/4e0348a4.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Restaurant](https://images.trvl-media.com/lodging/1000000/20000/15300/15254/c499b2e7.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Premium bedding, in-room safe, desk, laptop workspace](https://images.trvl-media.com/lodging/1000000/20000/15300/15254/3247fec2.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ### Beacon Grand, A Union Square Hotel [](https://www.expedia.co.uk/San-Francisco-Hotels-Sir-Francis-Drake-Hotel.h15254.Hotel-Information) Union Square, 1.6 mi from UCSF Mission Bay 9.2/10 Wonderful (1,942 reviews) "Loved this place. " ![United States](https://a.travel-assets.com/egds/marks/flags/us.svg) Liliana £175 includes taxes & fees 11 Apr - 12 Apr [](https://www.expedia.co.uk/San-Francisco-Hotels-Sir-Francis-Drake-Hotel.h15254.Hotel-Information) Lowest nightly price found within the past 24 hours based on a 1 night stay for 2 adults. Prices and availability subject to change. Additional terms may apply. [View all properties](https://expedia.co.uk/Hotel-Search?startDate=2026-04-11&endDate=2026-04-12®ionId=553248635389801411&adults=2&sort=RECOMMENDED&openPlayBack=true) ## Compare popular hotels close to UCSF Mission Bay | Property | Property class | Guest rating | Breakfast included | Pool | Spa | Pet-friendly | WiFi included | | | ---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------- | ----------------- | --------------------------- | ------------------ | ---- | --- | ------------ | ------------- | | | ![Coffee shop](https://images.trvl-media.com/lodging/71000000/70100000/70097200/70097106/7985eb30.jpg?impolicy=fcrop&w=900&h=675&p=1&q=medium)LUMA Hotel San Francisco | 4.0 star property | 9.6Exceptional2,425 reviews | View | | | | | | | ![Terrace/patio](https://images.trvl-media.com/lodging/32000000/31420000/31419900/31419890/91986f78.jpg?impolicy=fcrop&w=900&h=675&p=1&q=medium)Hyatt Place San Francisco Downtown | 3.0 star property | 9.4Exceptional2,066 reviews | View | | | | | | | ![Property entrance](https://images.trvl-media.com/lodging/17000000/16820000/16819700/16819669/004f15cd.jpg?impolicy=fcrop&w=900&h=675&p=1&q=medium)Hotel VIA | 4.0 star property | 9.2Wonderful1,527 reviews | View | | | | | | | ![Lobby](https://images.trvl-media.com/lodging/1000000/30000/22400/22303/e828523b.jpg?impolicy=fcrop&w=900&h=675&p=1&q=medium)Galleria Park Hotel | 4.0 star property | 9.6Exceptional1,003 reviews | View | | | | | | | ![Exterior](https://images.trvl-media.com/lodging/1000000/10000/500/491/c9a2355d.jpg?impolicy=fcrop&w=900&h=675&p=1&q=medium)Hyatt Regency San Francisco Downtown SOMA | 4.0 star property | 9.4Exceptional1,283 reviews | View | | | | | | ## Top UCSF Mission Bay Hotel Reviews ![Hilton San Francisco Financial District](https://images.trvl-media.com/lodging/1000000/10000/4400/4302/96ca1121_y.jpg) ### Hilton San Francisco Financial District 10/10 Excellent "Awesome 👏 " [](https://expedia.co.uk/San-Francisco-Hotels-Hilton-San-Francisco-Financial-District.h4302.Hotel-Information) ![Hilton San Francisco Union Square](https://images.trvl-media.com/lodging/1000000/30000/25700/25622/8fb5ec03_y.jpg) ### Hilton San Francisco Union Square 6/10 Okay "The hotel is not in the best location so beware! Once you walk outside you are near the Tenderloin to the left. Not a good area. The hotel completely price guaged due to conferences in the area. Three times the regular rate per night for an aging huge chain property is robbery! Stayed at many Hiltons that are in better shape, better locations, with better staff, at MUCH lower prices. We will not be back. The staff were not particularly friendly, except the bell hop. " [](https://expedia.co.uk/San-Francisco-Hotels-Hilton-San-Francisco-Union-Square.h25622.Hotel-Information) ![YOTEL San Francisco](https://images.trvl-media.com/lodging/20000000/19520000/19510300/19510249/9a7fa76b_y.jpg) ### YOTEL San Francisco 10/10 Excellent "All the staff are super friendly and the rooms are great!" [](https://expedia.co.uk/San-Francisco-Hotels-YOTEL-San-Francisco.h19510249.Hotel-Information) ![The Pickwick Hotel](https://images.trvl-media.com/lodging/1000000/20000/11800/11793/d655bded_y.jpg) ### The Pickwick Hotel 4/10 Poor "Very old, broken, the rug was dirtierc than the street, had to wear shoes inside. Just old, unupgraded, dirty and low class hotel. Very friendly staff though. They must upgrade." [](https://expedia.co.uk/San-Francisco-Hotels-The-Pickwick-Hotel.h11793.Hotel-Information) ![Hyatt Place San Francisco Downtown](https://images.trvl-media.com/lodging/32000000/31420000/31419900/31419890/91986f78_y.jpg) ### Hyatt Place San Francisco Downtown 10/10 Excellent "Front desk staff was great! I travel a lot and this front desk was the most helpful that I have ever experienced. " [](https://expedia.co.uk/San-Francisco-Hotels-Hyatt-Place-San-Francisco-Downtown.h31419890.Hotel-Information) ![Handlery Union Square Hotel](https://images.trvl-media.com/lodging/1000000/10000/6700/6666/4fd95a3a_y.jpg) ### Handlery Union Square Hotel 8/10 Good "The hotel was a clean but unfortunately when I arrived I didn’t know that parking was an extra charge per day. And if you want to self park it’s half a block away. We had to switch room through the night due to the ac going out, other people we’re having a similar problem so it took them a bit to get my room switched." [](https://expedia.co.uk/San-Francisco-Hotels-Handlery-Union-Square-Hotel.h6666.Hotel-Information) ![Holiday Inn Golden Gateway by IHG](https://images.trvl-media.com/lodging/1000000/20000/10600/10538/5971a3e7_y.jpg) ### Holiday Inn Golden Gateway by IHG 10/10 Excellent "Very nice location and condition was great" [](https://expedia.co.uk/San-Francisco-Hotels-Holiday-Inn-Golden-Gateway.h10538.Hotel-Information) ![The Utah Inn](https://images.trvl-media.com/lodging/9000000/8770000/8766600/8766561/54512707_y.jpg) ### The Utah Inn 2/10 Terrible "it smelled too bad to stay triggered my asthma. now put credit card has a $2,000 charge we did not put on it... " [](https://expedia.co.uk/San-Francisco-Hotels-The-Utah-Inn.h8766561.Hotel-Information) ![Bay Bridge Inn](https://images.trvl-media.com/lodging/2000000/1350000/1345200/1345121/4150dc88_y.jpg) ### Bay Bridge Inn 2/10 Terrible "Our car was vandalized, we saw a mouse on the motel sidewalk, the blanket was barely thicker than thw very cheap sheets, had to ask for more towels and rags immediately, three pillows for two people, smelled old, rough neighborhood, several blocks from amenities. " [](https://expedia.co.uk/San-Francisco-Hotels-Bay-Bridge-Inn.h1345121.Hotel-Information) ## Hotels near other UCSF Mission Bay attractions ![Chase Center San Francisco Skyline Aerial Photography](https://images.trvl-media.com/place/553248635997928290/197c9322-47b4-4ac5-bc8c-d25b082862ed.jpg) ### Chase Center Catch an event at Chase Center during your trip to San Francisco. Amble around this vibrant area's Chinatown or experience its entertainment choices. [See properties](https://www.expedia.co.uk/Hotel-Search?rfrrid=TG.LP..PointOfInterests®ionId=553248635997928290) ![](https://images.trvl-media.com/place/6155048/89f44ad0-efe6-42e1-ae0f-9ec45d9f9269.jpg) ### Anchor Brewing Company During your trip to San Francisco, you can do some window-shopping at Anchor Brewing Company. Discover the top-notch restaurants and fascinating museums in this vibrant area. [See properties](https://www.expedia.co.uk/Hotel-Search?rfrrid=TG.LP..PointOfInterests®ionId=6155048) ![](https://images.trvl-media.com/place/3132/6844d9ff-7d63-4da9-a600-a1e532dde0fd.jpg) Photo by Zhou You ### Oracle Park 4.3/5 (2,839 reviews) Whether or not you’re a baseball fan, this charming ballpark with outstanding views should be on your San Francisco sightseeing list. [See properties](https://www.expedia.co.uk/Hotel-Search?rfrrid=TG.LP..PointOfInterests®ionId=6063199) ### Mission Bay Conference Center at UCSF Learn about the events happening in Mission Bay Conference Center at UCSF during your trip to San Francisco. Amble around this vibrant area's Chinatown or experience its fascinating museums. [See properties](https://www.expedia.co.uk/Hotel-Search?rfrrid=TG.LP..PointOfInterests®ionId=818566843354574848) ### Mission Creek Park Mission Creek Park is just one of the places to see in San Francisco, so why not enjoy the other things to explore during your travels? Experience the fascinating museums and acclaimed theatre scene in this vibrant area. [See properties](https://www.expedia.co.uk/Hotel-Search?rfrrid=TG.LP..PointOfInterests®ionId=553248621555612179) ### Lefty O'Doul Bridge You can find out about the history of San Francisco with a stop at Lefty O'Doul Bridge. Take in the fascinating museums and beautiful sunsets in this vibrant area. [See properties](https://www.expedia.co.uk/Hotel-Search?rfrrid=TG.LP..PointOfInterests®ionId=6155190) ### Letterform Archive You can find out about the history of San Francisco when you stop by Letterform Archive. Take in the live music and sunsets in this walkable area. [See properties](https://www.expedia.co.uk/Hotel-Search?rfrrid=TG.LP..PointOfInterests®ionId=866963133062057984) ### McLellan Botanicals Enjoy the beautiful sunsets and explore McLellan Botanicals, a lovely green space in San Francisco. Experience the acclaimed theatre scene and fascinating museums in this vibrant area. [See properties](https://www.expedia.co.uk/Hotel-Search?rfrrid=TG.LP..PointOfInterests®ionId=553248621555612177) ## Frequently asked questions ### What's the area like around UCSF Mission Bay? ### What's the best place to stay near UCSF Mission Bay? ### How many hotels will I be able to find close to UCSF Mission Bay? ### If I need to cancel the hotel reservation for my stay near UCSF Mission Bay, will I receive a refund? ### What can I see and do near UCSF Mission Bay? ### How can I get to UCSF Mission Bay?