Title: The Best Hotels Closest to UCSF Mission Bay in San Francisco - 2026 Updated Prices | Expedia.co.uk [Downtown San Francisco Travel Guide](https://expedia.co.uk/San-Francisco-Downtown-San-Francisco.dx6151902)[UCSF Mission Bay Car Hire](https://expedia.co.uk/Compare-Cheap-Car-Hire-In-UCSF-Mission-Bay.d553248635389801411.Car-Hire-Guide)[UCSF Mission Bay Holidays](https://expedia.co.uk/UCSF-Mission-Bay-Downtown-San-Francisco.d553248635389801411.Attraction) ![Lodging Image](https://a.travel-assets.com/travel-assets-manager/bex-affinities/lodging.jpg?impolicy=fcrop&w=1200&h=500&q=medium) ![](https://a.travel-assets.com/travel-assets-manager/bex-affinities/lodging.jpg?impolicy=fcrop&w=1200&h=500&q=medium) - ![](https://a.travel-assets.com/travel-assets-manager/pictogram-bex/light__price_find.svg) ### Change your mind Book hotels with free cancellation - ![](https://a.travel-assets.com/travel-assets-manager/pictogram-bex/light__deals.svg) ### Treat yourself Save instantly and earn perks with One Key [Learn about One Key](https://www.expedia.co.uk/welcome-one-key) - ![](https://a.travel-assets.com/travel-assets-manager/pictogram-bex/light__bed.svg) ### Be picky Search almost a million properties worldwide ## Check prices for these dates Tonight [9 Feb - 10 Feb](https://www.expedia.co.uk/Hotel-Search?regionId=553248635389801411&startDate=2026-02-09&endDate=2026-02-10&adults=2&rfrr=TG.LP.CheckPrices.Hotel&openPlayBack=true) Tomorrow [10 Feb - 11 Feb](https://www.expedia.co.uk/Hotel-Search?regionId=553248635389801411&startDate=2026-02-10&endDate=2026-02-11&adults=2&rfrr=TG.LP.CheckPrices.Hotel&openPlayBack=true) This weekend [13 Feb - 15 Feb](https://www.expedia.co.uk/Hotel-Search?regionId=553248635389801411&startDate=2026-02-13&endDate=2026-02-15&adults=2&rfrr=TG.LP.CheckPrices.Hotel&openPlayBack=true) Next weekend [20 Feb - 22 Feb](https://www.expedia.co.uk/Hotel-Search?regionId=553248635389801411&startDate=2026-02-20&endDate=2026-02-22&adults=2&rfrr=TG.LP.CheckPrices.Hotel&openPlayBack=true) Recommended Price (low to high) Distance Property class ## Our top choices for UCSF Mission Bay hotels ![Tapas bar](https://images.trvl-media.com/lodging/71000000/70100000/70097200/70097106/58dd339c.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Front of property – evening/night](https://images.trvl-media.com/lodging/71000000/70100000/70097200/70097106/44e1b72d.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Restaurant](https://images.trvl-media.com/lodging/71000000/70100000/70097200/70097106/76aa0c86.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Restaurant](https://images.trvl-media.com/lodging/71000000/70100000/70097200/70097106/26f4395c.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ### LUMA Hotel San Francisco [](https://www.expedia.co.uk/San-Francisco-Hotels-LUMA-Hotel-San-Francisco.h70097106.Hotel-Information) 0.4 mi from UCSF Mission Bay 9.6/10 Exceptional (2,458 reviews) "Overall a great hotel!" ![United States](https://a.travel-assets.com/egds/marks/flags/us.svg) Ashley £172 includes taxes & fees 20 Feb - 21 Feb [](https://www.expedia.co.uk/San-Francisco-Hotels-LUMA-Hotel-San-Francisco.h70097106.Hotel-Information) ![Terrace/patio](https://images.trvl-media.com/lodging/32000000/31420000/31419900/31419890/91986f78.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Daily buffet breakfast (USD 16 per person)](https://images.trvl-media.com/lodging/32000000/31420000/31419900/31419890/f9d4387a.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Hypo-allergenic bedding, desk, laptop workspace, blackout curtains](https://images.trvl-media.com/lodging/32000000/31420000/31419900/31419890/b089b5be.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Lobby](https://images.trvl-media.com/lodging/32000000/31420000/31419900/31419890/6945eefa.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ### Hyatt Place San Francisco Downtown [](https://www.expedia.co.uk/San-Francisco-Hotels-Hyatt-Place-San-Francisco-Downtown.h31419890.Hotel-Information) 0.7 mi from UCSF Mission Bay 9.4/10 Exceptional (1,989 reviews) "Check-in and check-out went smoothly with staff, clean rooms and overall nice hotel. " ![United States](https://a.travel-assets.com/egds/marks/flags/us.svg) Giovanna £155 includes taxes & fees 13 Feb - 14 Feb [](https://www.expedia.co.uk/San-Francisco-Hotels-Hyatt-Place-San-Francisco-Downtown.h31419890.Hotel-Information) ![Property entrance](https://images.trvl-media.com/lodging/17000000/16820000/16819700/16819669/004f15cd.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Suite, 1 King Bed, Park View | Premium bedding, in-room safe, desk, blackout curtains](https://images.trvl-media.com/lodging/17000000/16820000/16819700/16819669/3c515aa8.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Interior detail](https://images.trvl-media.com/lodging/17000000/16820000/16819700/16819669/e4464a9a.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Lobby](https://images.trvl-media.com/lodging/17000000/16820000/16819700/16819669/4f46bfa5.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ### Hotel VIA [](https://www.expedia.co.uk/San-Francisco-Hotels-Hotel-VIA.h16819669.Hotel-Information) 0.7 mi from UCSF Mission Bay 9.2/10 Wonderful (1,514 reviews) "Great front desk staff , and great service " ![United States](https://a.travel-assets.com/egds/marks/flags/us.svg) Marcus £155 includes taxes & fees 15 Feb - 16 Feb [](https://www.expedia.co.uk/San-Francisco-Hotels-Hotel-VIA.h16819669.Hotel-Information) ![Lobby sitting area](https://images.trvl-media.com/lodging/1000000/30000/20600/20547/944f985c.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Property entrance](https://images.trvl-media.com/lodging/1000000/30000/20600/20547/17458474.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Suite, 1 Bedroom (Corporate) | Living area | 32-inch flat-screen TV with satellite channels, TV](https://images.trvl-media.com/lodging/1000000/30000/20600/20547/57a12208.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![In-room safe, desk, blackout curtains, iron/ironing board](https://images.trvl-media.com/lodging/1000000/30000/20600/20547/aff7fa14.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ### Chancellor Hotel on Union Square [](https://www.expedia.co.uk/San-Francisco-Hotels-Chancellor-Hotel-On-Union-Square.h20547.Hotel-Information) 1.6 mi from UCSF Mission Bay 9.4/10 Exceptional (3,193 reviews) "I loved this stay! Extremely friendly staff and amazing rooms" ![United States](https://a.travel-assets.com/egds/marks/flags/us.svg) Hajar £85 includes taxes & fees 11 Feb - 12 Feb [](https://www.expedia.co.uk/San-Francisco-Hotels-Chancellor-Hotel-On-Union-Square.h20547.Hotel-Information) ![Premium bedding, in-room safe, desk, laptop workspace](https://images.trvl-media.com/lodging/2000000/1770000/1766700/1766605/7856c00e.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Room amenity](https://images.trvl-media.com/lodging/2000000/1770000/1766700/1766605/5517eff5.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Meeting facility](https://images.trvl-media.com/lodging/2000000/1770000/1766700/1766605/da85ef17.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Premium bedding, in-room safe, desk, laptop workspace](https://images.trvl-media.com/lodging/2000000/1770000/1766700/1766605/3dcd0db5.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ### InterContinental San Francisco by IHG [](https://www.expedia.co.uk/San-Francisco-Hotels-InterContinental-San-Francisco.h1766605.Hotel-Information) South of Market, 1.1 mi from UCSF Mission Bay 9.2/10 Wonderful (1,089 reviews) "Very nice hotel, great amenities and excelente service " ![United States](https://a.travel-assets.com/egds/marks/flags/us.svg) Jessica £193 includes taxes & fees 13 Feb - 14 Feb [](https://www.expedia.co.uk/San-Francisco-Hotels-InterContinental-San-Francisco.h1766605.Hotel-Information) ![Property entrance](https://images.trvl-media.com/lodging/2000000/1520000/1516000/1515923/72e31d9d.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Lobby sitting area](https://images.trvl-media.com/lodging/2000000/1520000/1516000/1515923/ed3ae5f9.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![View from property](https://images.trvl-media.com/lodging/2000000/1520000/1516000/1515923/c2437688.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Bar (on property)](https://images.trvl-media.com/lodging/2000000/1520000/1516000/1515923/d07a1e26.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ### Orchard Garden Hotel [](https://www.expedia.co.uk/San-Francisco-Hotels-Orchard-Garden-Hotel.h1515923.Hotel-Information) Chinatown, 1.7 mi from UCSF Mission Bay 9.6/10 Exceptional (1,003 reviews) "Clean rooms, well run hotel, courteous staff." ![United States](https://a.travel-assets.com/egds/marks/flags/us.svg) joe £114 includes taxes & fees 15 Feb - 16 Feb [](https://www.expedia.co.uk/San-Francisco-Hotels-Orchard-Garden-Hotel.h1515923.Hotel-Information) ![3 bars/lounges](https://images.trvl-media.com/lodging/28000000/27120000/27110600/27110513/abad6cd0.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![3 bars/lounges](https://images.trvl-media.com/lodging/28000000/27120000/27110600/27110513/5335e149.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Exterior](https://images.trvl-media.com/lodging/28000000/27120000/27110600/27110513/04a59767.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Reception](https://images.trvl-media.com/lodging/28000000/27120000/27110600/27110513/5931a034.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ### Canopy by Hilton San Francisco SoMa [](https://www.expedia.co.uk/San-Francisco-Hotels-Canopy-By-Hilton-San-Francisco-SoMa.h27110513.Hotel-Information) South Park, 1.1 mi from UCSF Mission Bay 9.0/10 Wonderful (1,007 reviews) "Great place to stay" ![United States](https://a.travel-assets.com/egds/marks/flags/us.svg) Raquel £166 includes taxes & fees 7 Mar - 8 Mar [](https://www.expedia.co.uk/San-Francisco-Hotels-Canopy-By-Hilton-San-Francisco-SoMa.h27110513.Hotel-Information) ![Indoor pool](https://images.trvl-media.com/lodging/1000000/30000/23500/23406/b53af55a.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Executive lounge](https://images.trvl-media.com/lodging/1000000/30000/23500/23406/b267e1c4.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Lobby sitting area](https://images.trvl-media.com/lodging/1000000/30000/23500/23406/01ffa11d.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Property entrance](https://images.trvl-media.com/lodging/1000000/30000/23500/23406/308976ba.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ### Hotel Nikko San Francisco [](https://www.expedia.co.uk/San-Francisco-Hotels-Hotel-Nikko-San-Francisco.h23406.Hotel-Information) Union Square, 1.5 mi from UCSF Mission Bay 9.4/10 Exceptional (2,736 reviews) "Excellent welcome by staff and perfect room and breakfast. " ![United States](https://a.travel-assets.com/egds/marks/flags/us.svg) karen £195 includes taxes & fees 28 Feb - 1 Mar [](https://www.expedia.co.uk/San-Francisco-Hotels-Hotel-Nikko-San-Francisco.h23406.Hotel-Information) ![Exterior](https://images.trvl-media.com/lodging/2000000/1330000/1322000/1321986/a5681857.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Indoor pool](https://images.trvl-media.com/lodging/2000000/1330000/1322000/1321986/w4000h2662x0y0-41a38e25.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Indoor pool](https://images.trvl-media.com/lodging/2000000/1330000/1322000/1321986/w4000h2662x0y0-fc84c036.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Presidential Suite, 1 Bedroom | Frette Italian sheets, premium bedding, down duvets, pillow-top beds](https://images.trvl-media.com/lodging/2000000/1330000/1322000/1321986/45abbb57.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ### The St. Regis San Francisco [](https://www.expedia.co.uk/San-Francisco-Hotels-The-St-Regis-San-Francisco.h1321986.Hotel-Information) South of Market, 1.3 mi from UCSF Mission Bay 9.4/10 Exceptional (708 reviews) "The service was spectacular, enjoyed the restaurant as well as room service, and the room was very clean and spacious " ![United States](https://a.travel-assets.com/egds/marks/flags/us.svg) Lauren £383 includes taxes & fees 20 Feb - 21 Feb [](https://www.expedia.co.uk/San-Francisco-Hotels-The-St-Regis-San-Francisco.h1321986.Hotel-Information) ![Exterior](https://images.trvl-media.com/lodging/1000000/10000/500/491/c9a2355d.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Breakfast served](https://images.trvl-media.com/lodging/1000000/10000/500/491/b103963b.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Presidential Suite, 1 Bedroom | Living area | 55-inch flat-screen TV with cable channels, TV, pay films](https://images.trvl-media.com/lodging/1000000/10000/500/491/14a438d3.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Exterior](https://images.trvl-media.com/lodging/1000000/10000/500/491/fa08aa94.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ### Hyatt Regency San Francisco Downtown SOMA [](https://www.expedia.co.uk/San-Francisco-Hotels-The-Park-Central-San-Francisco-Hyatt-Affiliated-Hotel.h491.Hotel-Information) South of Market, 1.4 mi from UCSF Mission Bay 9.4/10 Exceptional (1,301 reviews) "Amazing, I would stay here again and recommend to family and friends. " ![United States](https://a.travel-assets.com/egds/marks/flags/us.svg) Tarandeep £173 includes taxes & fees 7 Mar - 8 Mar [](https://www.expedia.co.uk/San-Francisco-Hotels-The-Park-Central-San-Francisco-Hyatt-Affiliated-Hotel.h491.Hotel-Information) ![Lobby](https://images.trvl-media.com/lodging/1000000/700000/693700/693658/69c56718.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Serves dinner and happy hour](https://images.trvl-media.com/lodging/1000000/700000/693700/693658/da0bd574.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Front of property](https://images.trvl-media.com/lodging/1000000/700000/693700/693658/1656ff5c.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Courtyard](https://images.trvl-media.com/lodging/1000000/700000/693700/693658/e282d47e.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ### The Clancy, Autograph Collection by Marriott [](https://www.expedia.co.uk/San-Francisco-Hotels-The-Clancy.h693658.Hotel-Information) South Park, 1.2 mi from UCSF Mission Bay 9.2/10 Wonderful (1,002 reviews) "Great stay" ![United States](https://a.travel-assets.com/egds/marks/flags/us.svg) Corey £177 includes taxes & fees 6 Mar - 7 Mar [](https://www.expedia.co.uk/San-Francisco-Hotels-The-Clancy.h693658.Hotel-Information) ![Daily buffet breakfast (USD 22 per person)](https://images.trvl-media.com/lodging/70000000/69560000/69551600/69551553/w5519h4629x0y0-614e04d9.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![View from property](https://images.trvl-media.com/lodging/70000000/69560000/69551600/69551553/cadb58e5.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Lobby](https://images.trvl-media.com/lodging/70000000/69560000/69551600/69551553/1ab366ae.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Room, 1 King Bed (High Floor) | Premium bedding, pillow-top beds, in-room safe, desk](https://images.trvl-media.com/lodging/70000000/69560000/69551600/69551553/4835e3a9.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ### citizenM San Francisco Union Square [](https://www.expedia.co.uk/San-Francisco-Hotels-CitizenM-San-Francisco-Union-Square.h69551553.Hotel-Information) Union Square, 1.4 mi from UCSF Mission Bay 9.4/10 Exceptional (1,452 reviews) "Great location!" ![United States](https://a.travel-assets.com/egds/marks/flags/us.svg) Hunter £131 includes taxes & fees 28 Feb - 1 Mar [](https://www.expedia.co.uk/San-Francisco-Hotels-CitizenM-San-Francisco-Union-Square.h69551553.Hotel-Information) ![Terrace/patio](https://images.trvl-media.com/lodging/1000000/800000/791800/791769/bff475ef.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![LED TV, DVD player, iPod dock, first-run films](https://images.trvl-media.com/lodging/1000000/800000/791800/791769/7040d302.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Exterior](https://images.trvl-media.com/lodging/1000000/800000/791800/791769/ab6ff173.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Serves breakfast, lunch and dinner](https://images.trvl-media.com/lodging/1000000/800000/791800/791769/0cd41feb.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ### Four Seasons Hotel San Francisco [](https://www.expedia.co.uk/San-Francisco-Hotels-Four-Seasons-Hotel-San-Francisco.h791769.Hotel-Information) South of Market, 1.4 mi from UCSF Mission Bay 9.4/10 Exceptional (1,007 reviews) "great location, amazing hotel. great rooms. wonderful staff " ![United States](https://a.travel-assets.com/egds/marks/flags/us.svg) Majd £350 includes taxes & fees 6 Mar - 7 Mar [](https://www.expedia.co.uk/San-Francisco-Hotels-Four-Seasons-Hotel-San-Francisco.h791769.Hotel-Information) ![Exterior](https://images.trvl-media.com/lodging/1000000/290000/287200/287112/7fe7eb3b.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Penthouse, 1 Bedroom, City View | Living room | Flat-screen TV, pay films, MP3 dock](https://images.trvl-media.com/lodging/1000000/290000/287200/287112/3afd96af.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Flat-screen TV, pay films, MP3 dock](https://images.trvl-media.com/lodging/1000000/290000/287200/287112/0c9770db.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Property amenity](https://images.trvl-media.com/lodging/1000000/290000/287200/287112/f11ecdc1.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ### W San Francisco [](https://www.expedia.co.uk/San-Francisco-Hotels-W-San-Francisco.h287112.Hotel-Information) South Park, 1.2 mi from UCSF Mission Bay 9.0/10 Wonderful (1,004 reviews) "This hotel exceeded all expectations in every way. The accommodations, service, and atmosphere were exceptional. I truly enjoyed my stay and would not hesitate to return." ![United States](https://a.travel-assets.com/egds/marks/flags/us.svg) Andres £170 includes taxes & fees 6 Mar - 7 Mar [](https://www.expedia.co.uk/San-Francisco-Hotels-W-San-Francisco.h287112.Hotel-Information) ![View from property](https://images.trvl-media.com/lodging/1000000/30000/27300/27274/w4000h2663x0y0-df4f3756.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![View from property](https://images.trvl-media.com/lodging/1000000/30000/27300/27274/189643db.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![2 bars/lounges, cocktail bar](https://images.trvl-media.com/lodging/1000000/30000/27300/27274/59a0fd33.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![2 bars/lounges, cocktail bar](https://images.trvl-media.com/lodging/1000000/30000/27300/27274/e72fe89a.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ### Palace Hotel, a Luxury Collection Hotel, San Francisco [](https://www.expedia.co.uk/San-Francisco-Hotels-Palace-Hotel.h27274.Hotel-Information) Financial District, 1.4 mi from UCSF Mission Bay 9.2/10 Wonderful (1,003 reviews) "Stand outs: the staff, the pool, the polar bear Christmas decorations, and close to restaurants. " ![United States](https://a.travel-assets.com/egds/marks/flags/us.svg) Janet £248 includes taxes & fees 20 Feb - 21 Feb [](https://www.expedia.co.uk/San-Francisco-Hotels-Palace-Hotel.h27274.Hotel-Information) ![Bar (on property)](https://images.trvl-media.com/lodging/1000000/230000/225900/225819/48cf15fe.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Breakfast and dinner served](https://images.trvl-media.com/lodging/1000000/230000/225900/225819/b5cc10dd.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Junior Suite, 1 King Bed, City View, Corner | Premium bedding, in-room safe, desk, blackout curtains](https://images.trvl-media.com/lodging/1000000/230000/225900/225819/94c0b9bd.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Exterior](https://images.trvl-media.com/lodging/1000000/230000/225900/225819/de5c5a74.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ### Hotel Zelos San Francisco [](https://www.expedia.co.uk/San-Francisco-Hotels-Hotel-Zelos-San-Francisco.h225819.Hotel-Information) South of Market, 1.4 mi from UCSF Mission Bay 9.0/10 Wonderful (1,130 reviews) "Great hotel and staff. Perfect hub while in the city." ![United States](https://a.travel-assets.com/egds/marks/flags/us.svg) Nicholas £167 includes taxes & fees 1 Mar - 2 Mar [](https://www.expedia.co.uk/San-Francisco-Hotels-Hotel-Zelos-San-Francisco.h225819.Hotel-Information) ![55-inch TV with digital channels, pay films](https://images.trvl-media.com/lodging/1000000/30000/21100/21073/9e51cedf.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Room (Private Apartment) | Egyptian cotton sheets, premium bedding, minibar, in-room safe](https://images.trvl-media.com/lodging/1000000/30000/21100/21073/7626c0a6.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Combined shower/bathtub, rainfall showerhead, free toiletries](https://images.trvl-media.com/lodging/1000000/30000/21100/21073/40e87352.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Room (Private Apartment) | Egyptian cotton sheets, premium bedding, minibar, in-room safe](https://images.trvl-media.com/lodging/1000000/30000/21100/21073/174738f2.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ### The Clift Royal Sonesta San Francisco [](https://www.expedia.co.uk/San-Francisco-Hotels-The-Clift-Royal-Sonesta-San-Francisco.h21073.Hotel-Information) Theater District, 1.6 mi from UCSF Mission Bay 9.2/10 Wonderful (1,404 reviews) "Perfect location Great staff Very clean " ![United States](https://a.travel-assets.com/egds/marks/flags/us.svg) ELISA £166 includes taxes & fees 15 Feb - 16 Feb [](https://www.expedia.co.uk/San-Francisco-Hotels-The-Clift-Royal-Sonesta-San-Francisco.h21073.Hotel-Information) ![Exterior](https://images.trvl-media.com/lodging/97000000/96820000/96810700/96810663/febae001.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Reception](https://images.trvl-media.com/lodging/97000000/96820000/96810700/96810663/bf217857.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Lobby](https://images.trvl-media.com/lodging/97000000/96820000/96810700/96810663/b1b7eea9.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Deluxe Double Room | 1 bedroom, Egyptian cotton sheets, premium bedding, down duvets](https://images.trvl-media.com/lodging/97000000/96820000/96810700/96810663/00836df3.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ### Hotel Fiona [](https://www.expedia.co.uk/San-Francisco-Hotels-Hotel-Fiona.h96810663.Hotel-Information) South of Market, 1.2 mi from UCSF Mission Bay 8.6/10 Excellent (1,015 reviews) "Nice size room , comfy bed and nice staff and hotel convenient parking " ![United States](https://a.travel-assets.com/egds/marks/flags/us.svg) shawna £84 includes taxes & fees 10 Feb - 11 Feb [](https://www.expedia.co.uk/San-Francisco-Hotels-Hotel-Fiona.h96810663.Hotel-Information) ![Outdoor pool, a heated pool, open 8 AM to 8 PM, pool loungers](https://images.trvl-media.com/lodging/1000000/10000/6700/6666/4fd95a3a.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Lobby sitting area](https://images.trvl-media.com/lodging/1000000/10000/6700/6666/18d49d8b.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Exterior](https://images.trvl-media.com/lodging/1000000/10000/6700/6666/30aa972c.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Premier Room, 1 King Bed | Premium bedding, in-room safe, desk, laptop workspace](https://images.trvl-media.com/lodging/1000000/10000/6700/6666/9e50e45c.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ### Handlery Union Square Hotel [](https://www.expedia.co.uk/San-Francisco-Hotels-Handlery-Union-Square-Hotel.h6666.Hotel-Information) Union Square, 1.6 mi from UCSF Mission Bay 8.8/10 Excellent (2,862 reviews) "Friendly staff great location " ![United States](https://a.travel-assets.com/egds/marks/flags/us.svg) Tiffany £114 includes taxes & fees 5 Mar - 6 Mar [](https://www.expedia.co.uk/San-Francisco-Hotels-Handlery-Union-Square-Hotel.h6666.Hotel-Information) ![Cocktail bar](https://images.trvl-media.com/lodging/1000000/10000/8800/8737/ae4f08a6.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Exterior](https://images.trvl-media.com/lodging/1000000/10000/8800/8737/6ae4adf1.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Exterior](https://images.trvl-media.com/lodging/1000000/10000/8800/8737/153e8bb0.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Cocktail bar](https://images.trvl-media.com/lodging/1000000/10000/8800/8737/b19064bb.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ### San Francisco Marriott Marquis [](https://www.expedia.co.uk/San-Francisco-Hotels-San-Francisco-Marriott-Marquis.h8737.Hotel-Information) South of Market, 1.3 mi from UCSF Mission Bay 8.8/10 Excellent (1,243 reviews) "Convenient location " ![United States](https://a.travel-assets.com/egds/marks/flags/us.svg) Paolo £207 includes taxes & fees 12 Feb - 13 Feb [](https://www.expedia.co.uk/San-Francisco-Hotels-San-Francisco-Marriott-Marquis.h8737.Hotel-Information) Lowest nightly price found within the past 24 hours based on a 1 night stay for 2 adults. Prices and availability subject to change. Additional terms may apply. [View all properties](https://expedia.co.uk/Hotel-Search?startDate=2026-02-23&endDate=2026-02-24®ionId=553248635389801411&adults=2&sort=RECOMMENDED&openPlayBack=true) ## Compare popular hotels close to UCSF Mission Bay | Property | Property class | Guest rating | Breakfast included | Pool | Spa | Pet-friendly | WiFi included | | | ------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------- | ----------------- | --------------------------- | ------------------ | ---- | --- | ------------ | ------------- | | | ![Tapas bar](https://images.trvl-media.com/lodging/71000000/70100000/70097200/70097106/58dd339c.jpg?impolicy=fcrop&w=900&h=675&p=1&q=medium)LUMA Hotel San Francisco | 4.0 star property | 9.6Exceptional2,458 reviews | View | | | | | | | ![Terrace/patio](https://images.trvl-media.com/lodging/32000000/31420000/31419900/31419890/91986f78.jpg?impolicy=fcrop&w=900&h=675&p=1&q=medium)Hyatt Place San Francisco Downtown | 3.0 star property | 9.4Exceptional1,989 reviews | View | | | | | | | ![Property entrance](https://images.trvl-media.com/lodging/17000000/16820000/16819700/16819669/004f15cd.jpg?impolicy=fcrop&w=900&h=675&p=1&q=medium)Hotel VIA | 4.0 star property | 9.2Wonderful1,514 reviews | View | | | | | | | ![Lobby sitting area](https://images.trvl-media.com/lodging/1000000/30000/20600/20547/944f985c.jpg?impolicy=fcrop&w=900&h=675&p=1&q=medium)Chancellor Hotel on Union Square | 3.5 star property | 9.4Exceptional3,193 reviews | View | | | | | | | ![Premium bedding, in-room safe, desk, laptop workspace](https://images.trvl-media.com/lodging/2000000/1770000/1766700/1766605/7856c00e.jpg?impolicy=fcrop&w=900&h=675&p=1&q=medium)InterContinental San Francisco by IHG | 4.0 star property | 9.2Wonderful1,089 reviews | View | | | | | | ## Top UCSF Mission Bay Hotel Reviews ![Hotel Nikko San Francisco](https://images.trvl-media.com/lodging/1000000/30000/23500/23406/6c2cdc12_y.jpg) ### Hotel Nikko San Francisco 10/10 Excellent "Great location, nice room. Clean." [](https://expedia.co.uk/San-Francisco-Hotels-Hotel-Nikko-San-Francisco.h23406.Hotel-Information) ![Hotel Riu Plaza Fisherman's Wharf](https://images.trvl-media.com/lodging/1000000/30000/24700/24625/6fb55356_y.jpg) ### Hotel Riu Plaza Fisherman's Wharf 10/10 Excellent "Clean, friendly staff, great breakfast. " [](https://expedia.co.uk/San-Francisco-Hotels-Hotel-Riu-Plaza-Fishermans-Wharf.h24625.Hotel-Information) ![Hotel VIA](https://images.trvl-media.com/lodging/17000000/16820000/16819700/16819669/ce95cac7_y.jpg) ### Hotel VIA 10/10 Excellent "Room was clean and comfy! Perfect place to stay for a night out!" [](https://expedia.co.uk/San-Francisco-Hotels-Hotel-VIA.h16819669.Hotel-Information) ![YOTEL San Francisco](https://images.trvl-media.com/lodging/20000000/19520000/19510300/19510249/e1a4da25_y.jpg) ### YOTEL San Francisco 10/10 Excellent "Clean, modern, easy check in/out, affordable for a good location" [](https://expedia.co.uk/San-Francisco-Hotels-YOTEL-San-Francisco.h19510249.Hotel-Information) ![The Pickwick Hotel](https://images.trvl-media.com/lodging/1000000/20000/11800/11793/060ec935_y.jpg) ### The Pickwick Hotel 10/10 Excellent "The room was great easy access we rented two rooms one of the rooms. The television did not work in one of the rooms. Rooms were clean restrooms were clean. Well kept employees were nice and attend. Answered all questions. Thank you." [](https://expedia.co.uk/San-Francisco-Hotels-The-Pickwick-Hotel.h11793.Hotel-Information) ![Holiday Inn Golden Gateway by IHG](https://images.trvl-media.com/lodging/1000000/20000/10600/10538/9ba9bb1f_y.jpg) ### Holiday Inn Golden Gateway by IHG 10/10 Excellent "We arrived early and was able to get an early check in. Checkout was a breeze. " [](https://expedia.co.uk/San-Francisco-Hotels-Holiday-Inn-Golden-Gateway.h10538.Hotel-Information) ![Handlery Union Square Hotel](https://images.trvl-media.com/lodging/1000000/10000/6700/6666/b8dfc462_y.jpg) ### Handlery Union Square Hotel 10/10 Excellent "Thoroughly enjoyed our time here!!!!" [](https://expedia.co.uk/San-Francisco-Hotels-Handlery-Union-Square-Hotel.h6666.Hotel-Information) ![LUMA Hotel San Francisco ](https://images.trvl-media.com/lodging/71000000/70100000/70097200/70097106/f72650f9_y.jpg) ### LUMA Hotel San Francisco 10/10 Excellent "Love my stay. Clean, great location, friendly staff. " [](https://expedia.co.uk/San-Francisco-Hotels-LUMA-Hotel-San-Francisco.h70097106.Hotel-Information) ![Canopy by Hilton San Francisco SoMa](https://images.trvl-media.com/lodging/28000000/27120000/27110600/27110513/7ea03f76_y.jpg) ### Canopy by Hilton San Francisco SoMa 10/10 Excellent "Clean nice front desk amazing coffe love love the views!!! perfect hotel close to everything!! " [](https://expedia.co.uk/San-Francisco-Hotels-Canopy-By-Hilton-San-Francisco-SoMa.h27110513.Hotel-Information) ## Hotels near other UCSF Mission Bay attractions ![Chase Center San Francisco Skyline Aerial Photography](https://images.trvl-media.com/place/553248635997928290/197c9322-47b4-4ac5-bc8c-d25b082862ed.jpg) ### Chase Center Catch an event at Chase Center during your trip to San Francisco. Amble around this vibrant area's Chinatown or experience its fascinating museums. [See properties](https://www.expedia.co.uk/Hotel-Search?rfrrid=TG.LP..PointOfInterests®ionId=553248635997928290) ![Anchor Brewing Company](https://images.trvl-media.com/place/6155048/89f44ad0-efe6-42e1-ae0f-9ec45d9f9269.jpg) ### Anchor Brewing Company During your trip to San Francisco, you can do some window-shopping at Anchor Brewing Company. Discover the top-notch restaurants and acclaimed theatre scene in this vibrant area. [See properties](https://www.expedia.co.uk/Hotel-Search?rfrrid=TG.LP..PointOfInterests®ionId=6155048) ![Always packed, lose or win. ](https://images.trvl-media.com/place/3132/6844d9ff-7d63-4da9-a600-a1e532dde0fd.jpg) Photo by Zhou You ### Oracle Park 4.3/5 (2,839 reviews) Whether or not you’re a baseball fan, this charming ballpark with outstanding views should be on your San Francisco sightseeing list. [See properties](https://www.expedia.co.uk/Hotel-Search?rfrrid=TG.LP..PointOfInterests®ionId=6063199) ### Mission Bay Conference Center at UCSF Learn about the events happening in Mission Bay Conference Center at UCSF during your trip to San Francisco. Amble around this vibrant area's Chinatown or experience its entertainment choices. [See properties](https://www.expedia.co.uk/Hotel-Search?rfrrid=TG.LP..PointOfInterests®ionId=818566843354574848) ### Mission Creek Park Mission Creek Park is just one of the places to see in San Francisco, so why not enjoy the other things to explore during your travels? Experience the fascinating museums and acclaimed theatre scene in this vibrant area. [See properties](https://www.expedia.co.uk/Hotel-Search?rfrrid=TG.LP..PointOfInterests®ionId=553248621555612179) ### Lefty O'Doul Bridge You can find out about the history of San Francisco with a stop at Lefty O'Doul Bridge. Take in the acclaimed theatre scene and beautiful sunsets in this vibrant area. [See properties](https://www.expedia.co.uk/Hotel-Search?rfrrid=TG.LP..PointOfInterests®ionId=6155190) ### Letterform Archive You can find out about the history of San Francisco when you stop by Letterform Archive. Take in the live music and sunsets in this walkable area. [See properties](https://www.expedia.co.uk/Hotel-Search?rfrrid=TG.LP..PointOfInterests®ionId=866963133062057984) ### McLellan Botanicals Enjoy the beautiful sunsets and explore McLellan Botanicals, a lovely green space in San Francisco. Experience the fascinating museums and acclaimed theatre scene in this vibrant area. [See properties](https://www.expedia.co.uk/Hotel-Search?rfrrid=TG.LP..PointOfInterests®ionId=553248621555612177) ## Frequently asked questions ### What's the area like around UCSF Mission Bay? ### What's the best place to stay near UCSF Mission Bay? ### How many hotels will I be able to find close to UCSF Mission Bay? ### If I need to cancel the hotel reservation for my stay near UCSF Mission Bay, will I receive a refund? ### What can I see and do near UCSF Mission Bay? ### How can I get to UCSF Mission Bay?