--- title: "The Best Hotels Closest to St. Louis Science Center in St. Louis - 2026 Updated Prices | Expedia" description: "Stay close to St. Louis Science Center. Search 250 hotels near St. Louis Science Center in St. Louis from £76. Compare room rates, hotel reviews and availability. Most hotels are fully refundable." canonical: "https://www.expedia.co.uk/St-Louis-Science-Center-Hotels.0-l502861-0.Travel-Guide-Filter-Hotels" language: en-GB market: GB currency: GBP prices_as_of: 2026-11-13T10:32:19Z --- Plan your trip - [Kings-Oak Travel Guide](https://www.expedia.co.uk/St-Louis-Kings-Oak.dx896161834730729472) - [Car Hire in St. Louis Science Center](https://www.expedia.co.uk/Compare-Cheap-Car-Hire-In-St-Louis-Science-Center.d502861.Car-Hire-Guide) - [St. Louis Science Center Holidays](https://www.expedia.co.uk/St-Louis-Science-Center-Kings-Oak.d502861.Attraction) # Search Hotels Near St. Louis Science Center, St. Louis ![A space shuttle exhibit with a large model of a space shuttle, a red pillar, and informational displays.](https://images.trvl-media.com/place/502861/56d3c976-c903-40c9-a087-9c21ff965eff.jpg?impolicy=fcrop&w=1200&h=500&q=medium) ### Change your mind Book hotels with free cancellation ### Treat yourself Save instantly and earn perks with One Key [Learn about One Key](https://www.expedia.co.uk/welcome-one-key) ### Be picky Search almost a million properties worldwide ## Check prices for these dates [Check prices for these dates, 13 – 14 December 2026](https://www.expedia.co.uk/Hotel-Search?regionId=502861&startDate=2026-12-13&endDate=2026-12-14&adults=2&rfrr=TG.LP.CheckPrices.Hotel&openPlayBack=true) [View in a map](https://www.expedia.co.uk/Hotel-Search?regionId=502861&stayLength=1&daysInFuture=30&pwaOverlay=map) Recommended Price (low to high) Distance Property class ## Our top choices for St. Louis Science Center hotels ### [1\. Hampton Inn & Suites St. Louis at Forest Park](https://www.expedia.co.uk/St-Louis-Hotels-Hampton-Inn-Suites-St-Louis-At-Forest-Park.h1427801.Hotel-Information) ![A hotel with a modern design, featuring a large entrance, multiple floors, and a parking lot.](https://images.trvl-media.com/lodging/2000000/1430000/1427900/1427801/8b38b72c.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) - Location: Dogtown, 0.6 mi from St. Louis Science Center - Guest rating: 9.4/10 (Exceptional, 1000 reviews) - Price: £116, includes taxes & fees, 22 Nov - 23 Nov, for Our top choices for St. Louis Science Center hotels - Review: Nice hotel near WashUand Forest Park. It is clean and parking is easy., by Edmond ### [2\. Drury Inn & Suites St. Louis Forest Park](https://www.expedia.co.uk/St-Louis-Hotels-Drury-Inn-Suites-St-Louis-Forest-Park.h1717380.Hotel-Information) ![Lobby](https://images.trvl-media.com/lodging/2000000/1720000/1717400/1717380/f33ef2ea.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) - Location: 1.3 mi from St. Louis Science Center - Guest rating: 9.4/10 (Exceptional, 1029 reviews) - Price: £119, includes taxes & fees, 18 Nov - 19 Nov, for Our top choices for St. Louis Science Center hotels - Review: Loved staying there!, by Tammy ### [3\. The Royal Sonesta Chase Park Plaza St. Louis](https://www.expedia.co.uk/St-Louis-Hotels-The-Chase-Park-Plaza-Royal-Sonesta-St-Louis.h465749.Hotel-Information) ![A hotel with a swimming pool, lounge chairs, and a courtyard with palm trees.](https://images.trvl-media.com/lodging/1000000/470000/465800/465749/9bee4fd7.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) - Location: Central West End, 1.1 mi from St. Louis Science Center - Guest rating: 9.2/10 (Wonderful, 1002 reviews) - Price: £141, includes taxes & fees, 22 Nov - 23 Nov, for Our top choices for St. Louis Science Center hotels - Review: The hotel is beautiful, and we really enjoyed the restaurants--The Tenderloin Room was especially delicious!, by Sara ### [4\. AC Hotel St. Louis Central West End](https://www.expedia.co.uk/St-Louis-Hotels-AC-Hotel-St-Louis-Central-West-End.h71082568.Hotel-Information) ![A modern hotel with a central entrance, large windows, and a brick facade.](https://images.trvl-media.com/lodging/72000000/71090000/71082600/71082568/0b944f11.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) - Location: Central West End, 1.1 mi from St. Louis Science Center - Guest rating: 9/10 (Wonderful, 863 reviews) - Price: £128, includes taxes & fees, 20 Nov - 21 Nov, for Our top choices for St. Louis Science Center hotels - Review: Everything at this hotel was perfect. From the valet to the front desk to the breakfast were so friendly and nice. We will definitely stay here again. The location is also perfect, by Janice ### [5\. Hotel Indigo St Louis - Central West End by IHG](https://www.expedia.co.uk/St-Louis-Hotels-Holiday-Inn-Express-St-Louis-Central-West-End.h22068.Hotel-Information) ![An outdoor dining area with multiple wooden tables and benches, surrounded by wicker chairs.](https://images.trvl-media.com/lodging/1000000/30000/22100/22068/bd89b9ce.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) - Location: Central West End, 1.1 mi from St. Louis Science Center - Guest rating: 8.8/10 (Excellent, 1001 reviews) - Price: £119, includes taxes & fees, 22 Nov - 23 Nov, for Our top choices for St. Louis Science Center hotels - Review: Great place, bar and food was excellent. Would definitely stay here again., by Gordon ### [6\. Element by Marriott St. Louis Midtown](https://www.expedia.co.uk/St-Louis-Hotels-Element-St-Louis-Midtown.h57057177.Hotel-Information) ![A modern bar area with a long counter, bar stools, and a variety of bottles.](https://images.trvl-media.com/lodging/58000000/57060000/57057200/57057177/8a51369f.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) - Location: Midtown, 1.7 mi from St. Louis Science Center - Guest rating: 8.8/10 (Excellent, 860 reviews) - Price: £118, includes taxes & fees, 22 Nov - 23 Nov, for Our top choices for St. Louis Science Center hotels - Review: Would stay again!, by Julie ### [7\. The West End](https://www.expedia.co.uk/St-Louis-Hotels-The-West-End.h106715696.Hotel-Information) ![A hot tub with a wooden deck, surrounded by a bamboo fence, and string lights.](https://images.trvl-media.com/lodging/107000000/106720000/106715700/106715696/74ffd1da.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) - Location: Central West End, 1.4 mi from St. Louis Science Center - Guest rating: 8.6/10 (Excellent, 716 reviews) - Price: £77, includes taxes & fees, 16 Nov - 17 Nov, for Our top choices for St. Louis Science Center hotels - Review: Super Nice staff and the room was clean, by Adam ### [8\. Aloft by Marriott St Louis Central West End](https://www.expedia.co.uk/St-Louis-Hotels-Aloft-By-Marriott-St-Louis-Central-West-End.h49290300.Hotel-Information) ![An outdoor dining area with a glass table and chairs, a neon sign, and a city view.](https://images.trvl-media.com/lodging/50000000/49300000/49290300/49290300/9e2fb714.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) - Location: Central West End, 1.1 mi from St. Louis Science Center - Guest rating: 8.6/10 (Excellent, 1000 reviews) - Price: £100, includes taxes & fees, 22 Nov - 23 Nov, for Our top choices for St. Louis Science Center hotels - Review: Very nice staff and helped us with all our needs and was close to the event we were going to and loved the pool table and pool they had there, by Brittany ### [9\. Home2 Suites by Hilton St. Louis/Forest Park](https://www.expedia.co.uk/St-Louis-Hotels-Home2-Suites-By-Hilton-St-LouisForest-Park.h10503041.Hotel-Information) ![An outdoor seating area with a fire pit, cushioned benches, and a covered patio with string lights.](https://images.trvl-media.com/lodging/11000000/10510000/10503100/10503041/c6cc2b03.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) - Location: The Grove, 0.5 mi from St. Louis Science Center - Guest rating: 8.6/10 (Excellent, 1001 reviews) - Price: £126, includes taxes & fees, 7 Dec - 8 Dec, for Our top choices for St. Louis Science Center hotels - Review: Very nice place to stay., by Ruth ### [10\. DoubleTree by Hilton St. Louis Forest Park](https://www.expedia.co.uk/St-Louis-Hotels-DoubleTree-By-Hilton-St-Louis-Forest-Park.h1082373.Hotel-Information) ![A multi-story hotel with a flat facade, numerous windows, and a prominent DoubleTree by Hilton sign.](https://images.trvl-media.com/lodging/2000000/1090000/1082400/1082373/e0ab2dfe.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) - Location: Central West End, 0.8 mi from St. Louis Science Center - Guest rating: 8.4/10 (Very good, 1005 reviews) - Price: £127, includes taxes & fees, 22 Nov - 23 Nov, for Our top choices for St. Louis Science Center hotels - Review: Great stay, for the price!! And... the cookies were awesome!!!...LOL, by Garland ### [11\. White House at Grand Central](https://www.expedia.co.uk/St-Louis-Hotels-Grand-Center-Apartments.h83121050.Hotel-Information) ![A spacious living room with a beige sofa, a dining area with a table and chairs, large windows, and a chandelier.](https://images.trvl-media.com/lodging/84000000/83130000/83121100/83121050/8b6b6dfd.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) - Location: 1.8 mi from St. Louis Science Center - Guest rating: 8.2/10 (Very good, 170 reviews) - Price: £93, includes taxes & fees, 16 Nov - 17 Nov, for Our top choices for St. Louis Science Center hotels - Review: Very spacious clean old house apartments, by Priscilla ### [12\. Forest Park Hotel by MDR](https://www.expedia.co.uk/St-Louis-Hotels-Holiday-Inn-St-Louis-Forest-Park.h22298.Hotel-Information) ![A hotel room with a bed, a sofa, a desk, and a view of the outdoors.](https://images.trvl-media.com/lodging/1000000/30000/22300/22298/574b1ab4.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) - Location: The Hill, 1.1 mi from St. Louis Science Center - Guest rating: 7.4/10 (Good, 1706 reviews) - Price: £68, includes taxes & fees, 14 Dec - 15 Dec, for Our top choices for St. Louis Science Center hotels - Review: Everything is good in this hotel, by Frantz ### [13\. Red Roof Inn PLUS+ St Louis - Forest Park/ Hampton Ave](https://www.expedia.co.uk/St-Louis-Hotels-Red-Roof-Inn-PLUS-St-Louis-Forest-Park-Hampton-Ave.h24411.Hotel-Information) ![A Red Roof Plus hotel with a modern architectural design, featuring a prominent red and white color scheme, a flat roof, and a well-lit entrance.](https://images.trvl-media.com/lodging/1000000/30000/24500/24411/4407b624.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) - Location: The Hill, 1.1 mi from St. Louis Science Center - Guest rating: 6/10 (1004 reviews) - Price: £64, includes taxes & fees, 18 Nov - 19 Nov, for Our top choices for St. Louis Science Center hotels - Review: Okay for a one night stay., by Sean ### [14\. Truitt Hotel](https://www.expedia.co.uk/St-Louis-Hotels-Truitt-Hotel.h133833207.Hotel-Information) ![A room with a dark wooden door, a chandelier, green plants, and a seating area with a sofa and chairs.](https://images.trvl-media.com/lodging/134000000/133840000/133833300/133833207/d4704afb.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) - Location: Lafayette Square, 3.1 mi from St. Louis Science Center - Guest rating: 10/10 (Exceptional, 32 reviews) - Price: £154, includes taxes & fees, 16 Nov - 17 Nov, for Our top choices for St. Louis Science Center hotels - Review: Amazing stay, gorgeous rooms and buildings, perfect getaway, by Gabrielle ### [15\. Drury Plaza Hotel St. Louis at the Arch](https://www.expedia.co.uk/St-Louis-Hotels-Drury-Plaza-Hotel-St-Louis-At-The-Arch.h546271.Hotel-Information) ![A rooftop terrace with wicker chairs and a glass balustrade overlooking a bridge.](https://images.trvl-media.com/lodging/1000000/550000/546300/546271/d1cd3844.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) - Location: Downtown St. Louis, 4.4 mi from St. Louis Science Center - Guest rating: 9.6/10 (Exceptional, 3833 reviews) - Price: £119, includes taxes & fees, 13 Dec - 14 Dec, for Our top choices for St. Louis Science Center hotels - Review: Very nice hotel.. love that are arch is right behind it.., by Nicole ### [16\. Drury Plaza Hotel St. Louis Brentwood](https://www.expedia.co.uk/St-Louis-Hotels-Drury-Inn-Suites-St-Louis-Brentwood.h8354160.Hotel-Information) ![A restaurant with round tables and chairs, a bar area, and a patterned ceiling.](https://images.trvl-media.com/lodging/9000000/8360000/8354200/8354160/e334fb85.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) - Location: 4 mi from St. Louis Science Center - Guest rating: 9.6/10 (Exceptional, 1012 reviews) - Price: £109, includes taxes & fees, 13 Dec - 14 Dec, for Our top choices for St. Louis Science Center hotels - Review: Really enjoyed the breakfast and happy hours!, by Stacey Rochelle ### [17\. Pear Tree Inn St. Louis Airport](https://www.expedia.co.uk/St-Louis-Hotels-Pear-Tree-Inn-St-Louis-Airport.h1096579.Hotel-Information) ![A spacious lobby with modern seating, a reception desk, and large windows offering views of the parking area.](https://images.trvl-media.com/lodging/2000000/1100000/1096600/1096579/fc156cf2.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) - Location: 9.3 mi from St. Louis Science Center - Guest rating: 9.4/10 (Exceptional, 3362 reviews) - Price: £81, includes taxes & fees, 18 Nov - 19 Nov, for Our top choices for St. Louis Science Center hotels - Review: Great stay for airport access, by Rebecca ### [18\. The Lodge at Grant's Trail](https://www.expedia.co.uk/St-Louis-Hotels-The-Lodge-At-Grants-Trail.h12513911.Hotel-Information) ![A multi-story wooden building with balconies and outdoor seating, likely a lodge or hotel.](https://images.trvl-media.com/lodging/13000000/12520000/12514000/12513911/be37ed23.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) - Location: 6.3 mi from St. Louis Science Center - Guest rating: 9.6/10 (Exceptional, 542 reviews) - Price: £162, includes taxes & fees, 18 Nov - 19 Nov, for Our top choices for St. Louis Science Center hotels - Review: It was absolutely beautiful and welcoming definitely plan on coming back., by Sherri ### [19\. The Knight Center at Washington University](https://www.expedia.co.uk/St-Louis-Hotels-The-Charles-F-Knight-Center.h38711810.Hotel-Information) ![A courtyard with outdoor seating, a central fountain, and a view of a tower.](https://images.trvl-media.com/lodging/39000000/38720000/38711900/38711810/a9bf89ab.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) - Location: 2.7 mi from St. Louis Science Center - Guest rating: 9.4/10 (Exceptional, 724 reviews) - Price: £119, includes taxes & fees, 28 Nov - 29 Nov, for Our top choices for St. Louis Science Center hotels - Review: Perfect location. Beautiful hotel., by April ### [20\. Live by Loews - St.Louis](https://www.expedia.co.uk/St-Louis-Hotels-Live-By-Loews-StLouis.h39161277.Hotel-Information) ![A modern outdoor lounge area with seating, a bar, and a view of a cityscape.](https://images.trvl-media.com/lodging/40000000/39170000/39161300/39161277/4c39e93f.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) - Location: Downtown St. Louis, 4.2 mi from St. Louis Science Center - Guest rating: 9.4/10 (Exceptional, 1364 reviews) - Price: £125, includes taxes & fees, 22 Nov - 23 Nov, for Our top choices for St. Louis Science Center hotels - Review: Great place to stay., by brandon Lowest nightly price found within the past 24 hours based on a 1 night stay for 2 adults. Prices and availability subject to change. Additional terms may apply. [View all properties](https://www.expedia.co.uk/Hotel-Search?startDate=2026-11-27&endDate=2026-11-28®ionId=502861&adults=2&sort=RECOMMENDED&openPlayBack=true) ## Compare popular hotels close to St. Louis Science Center | Property | Property class | Guest rating | Breakfast included | Pool | Spa | Pet-friendly | WiFi included | | ------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------- | --------------------------- | ------------ | ------------------ | ---- | --- | ------------ | ------------- | | ![A hotel with a modern design, featuring a large entrance, multiple floors, and a parking lot.](https://images.trvl-media.com/lodging/2000000/1430000/1427900/1427801/8b38b72c.jpg?impolicy=fcrop&w=900&h=675&p=1&q=medium)Hampton Inn & Suites St. Louis at Forest Park | 9.4Exceptional1,000 reviews | View | | | | | | | ![Lobby](https://images.trvl-media.com/lodging/2000000/1720000/1717400/1717380/f33ef2ea.jpg?impolicy=fcrop&w=900&h=675&p=1&q=medium)Drury Inn & Suites St. Louis Forest Park | 9.4Exceptional1,029 reviews | View | | | | | | | ![A hotel with a swimming pool, lounge chairs, and a courtyard with palm trees.](https://images.trvl-media.com/lodging/1000000/470000/465800/465749/9bee4fd7.jpg?impolicy=fcrop&w=900&h=675&p=1&q=medium) The Royal Sonesta Chase Park Plaza St. Louis | 9.2Wonderful1,002 reviews | View | | | | | | | ![A modern hotel with a central entrance, large windows, and a brick facade.](https://images.trvl-media.com/lodging/72000000/71090000/71082600/71082568/0b944f11.jpg?impolicy=fcrop&w=900&h=675&p=1&q=medium)AC Hotel St. Louis Central West End | 9.0Wonderful863 reviews | View | | | | | | | ![An outdoor dining area with multiple wooden tables and benches, surrounded by wicker chairs.](https://images.trvl-media.com/lodging/1000000/30000/22100/22068/bd89b9ce.jpg?impolicy=fcrop&w=900&h=675&p=1&q=medium)Hotel Indigo St Louis - Central West End by IHG | 8.8Excellent1,001 reviews | View | | | | | | ## Other attractions near St. Louis Science Center ### Jewel Box ![A modern building with large glass windows and a garden with red and pink tulips.](https://images.trvl-media.com/place/553248635823456129/862080eb-b3f3-4882-80ed-4ae6ae6bc9ab.jpg?impolicy=fcrop&w=960&h=640&p=1&q=medium) Made of stacked glass in a restored art deco style, this glass house from the 1930s continues to flourish with tropical trees, hanging plants and a large fountain. [See properties](https://www.expedia.co.uk/Hotel-Search?rfrrid=TG.LP..PointOfInterests®ionId=553248635823456129) ### Forest Park ![A stone fountain with water cascading down a tiered structure, surrounded by a pond and a grassy area with a building in the background.](https://images.trvl-media.com/place/6005687/7310cc7c-f4fc-4306-95ca-a3c544655533.jpg?impolicy=fcrop&w=960&h=640&p=1&q=medium) Rating: 9.2/10 (3,389 reviews) Nature, history and cultural institutions come together in one of the United States’ largest urban parks, which buzzes with St. Louis’ dynamic community spirit. [See properties](https://www.expedia.co.uk/Hotel-Search?rfrrid=TG.LP..PointOfInterests®ionId=6005687) ### Pagoda Circle ![A gazebo with columns and a dome roof, surrounded by a pond and greenery.](https://images.trvl-media.com/place/553248635810227311/1a3c426c-0102-47a7-a244-05819335714b.jpg?impolicy=fcrop&w=960&h=640&p=1&q=medium) As one of the cornerstones of Forest Park for about a century, this grassy island and its bandstand offer an excellent concert spot. [See properties](https://www.expedia.co.uk/Hotel-Search?rfrrid=TG.LP..PointOfInterests®ionId=553248635810227311) ### The Muny Theater ![A theater stage with a variety of neon signs advertising different businesses.](https://images.trvl-media.com/place/6064093/e3b09d3d-c445-440e-a46c-1662e40bba1a.jpg?impolicy=fcrop&w=960&h=640&p=1&q=medium) Rating: 8.6/10 (7 reviews) You can get tickets for a performance at The Muny Theater during your trip to St. Louis. Amble around the area's lush forest or attend a sporting event. [See properties](https://www.expedia.co.uk/Hotel-Search?rfrrid=TG.LP..PointOfInterests®ionId=6064093) ### Highlands Golf & Tennis Center Catch an event at Highlands Golf & Tennis Center during your trip to St. Louis. Experience the area's entertainment choices or attend a baseball game. [See properties](https://www.expedia.co.uk/Hotel-Search?rfrrid=TG.LP..PointOfInterests®ionId=941624749059428352) ### Atomic Cowboy Atomic Cowboy is just one of the places to see in St. Louis, so why not enjoy the other things to explore during your travels? [See properties](https://www.expedia.co.uk/Hotel-Search?rfrrid=TG.LP..PointOfInterests®ionId=1020701371844124672) ### Atomic by Jamo Atomic by Jamo is just one of the places to see in St. Louis, so why not enjoy the other things to explore during your travels? [See properties](https://www.expedia.co.uk/Hotel-Search?rfrrid=TG.LP..PointOfInterests®ionId=1020700685446279168) ## Top St. Louis Science Center Hotel Reviews ### [Hampton Inn & Suites St. Louis at Forest Park](https://www.expedia.co.uk/St-Louis-Hotels-Hampton-Inn-Suites-St-Louis-At-Forest-Park.h1427801.Hotel-Information) ![A hotel with a modern design, featuring a large entrance, multiple floors, and a parking lot.](https://images.trvl-media.com/lodging/2000000/1430000/1427900/1427801/8b38b72c.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) - Address: 5650 Oakland Avenue, St. Louis, MO, 63110, US - Location: Dogtown - Star rating: 3.5/5 - Guest rating: 9.4/10 (1000 reviews) - Review: Convenient location. Comfy beds., by john, 21 September 2025, rated 8/10 Good ### [Drury Inn & Suites St. Louis Forest Park](https://www.expedia.co.uk/St-Louis-Hotels-Drury-Inn-Suites-St-Louis-Forest-Park.h1717380.Hotel-Information) ![Lobby](https://images.trvl-media.com/lodging/2000000/1720000/1717400/1717380/f33ef2ea.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) - Address: 2111 Sulphur Avenue, St. Louis, MO, 63139, US - Location: Clifton Heights - Star rating: 3/5 - Guest rating: 9.4/10 (1029 reviews) - Review: Staff and hotel were great. Would definitely stay again. We’d never stayed in a Drury Inn before so the drinks and food in the evening was a lovely touch. Highly recommend, by Joe, 12 August 2024, rated 10/10 Excellent ### [Drury Plaza Hotel St. Louis Brentwood](https://www.expedia.co.uk/St-Louis-Hotels-Drury-Inn-Suites-St-Louis-Brentwood.h8354160.Hotel-Information) ![A restaurant with round tables and chairs, a bar area, and a patterned ceiling.](https://images.trvl-media.com/lodging/9000000/8360000/8354200/8354160/e334fb85.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) - Address: 8700 Eager Rd, Brentwood, MO, 63144, US - Location: Brentwood - Star rating: 4/5 - Guest rating: 9.6/10 (1012 reviews) - Review: Clean room and clean hotel. Receptionist was excellent when we arrived, explained everything we needed to know. Would definitely recommend this hotel., by Andrew, 9 August 2026, rated 10/10 Excellent ### [Drury Plaza Hotel St. Louis at the Arch](https://www.expedia.co.uk/St-Louis-Hotels-Drury-Plaza-Hotel-St-Louis-At-The-Arch.h546271.Hotel-Information) ![A rooftop terrace with wicker chairs and a glass balustrade overlooking a bridge.](https://images.trvl-media.com/lodging/1000000/550000/546300/546271/d1cd3844.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) - Address: 2 South 4th Street, St. Louis, MO, 63102, US - Location: Downtown St. Louis - Star rating: 3/5 - Guest rating: 9.6/10 (3833 reviews) - Review: All was great, huge room, kickback was also good, lovely breakfast would stay again.., by julie, 17 March 2026, rated 10/10 Excellent ### [Drury Plaza Hotel St. Louis Union Station](https://www.expedia.co.uk/St-Louis-Hotels-Drury-Inn-Suites-St-Louis-Union-Station.h37651.Hotel-Information) ![An indoor pool area with a hot tub, seating, and a stone wall.](https://images.trvl-media.com/lodging/1000000/40000/37700/37651/151222b4.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) - Location: Downtown West - Review: Breakfast and evening kickback was adequate, room was large with microwave and fridge., by Kevin, 15 September 2026, rated 10/10 Excellent ### [The Knight Center at Washington University](https://www.expedia.co.uk/St-Louis-Hotels-The-Charles-F-Knight-Center.h38711810.Hotel-Information) ![A courtyard with outdoor seating, a central fountain, and a view of a tower.](https://images.trvl-media.com/lodging/39000000/38720000/38711900/38711810/a9bf89ab.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) - Address: Throop Drive and Snow Way, St. Louis, MO, 63130, US - Location: St. Louis - Star rating: 2.5/5 - Guest rating: 9.4/10 (724 reviews) - Review: Stayed here for 2 nights. Lovely place. The lady on the front desk was great, telling us how to get about in St Louis and how far away we were from certain areas. 15 mins walk to the Delmar loop. 7 mins walk to the metro. Would 100% recommend staying here., by James, 4 August 2026, rated 10/10 Excellent ### [Residence Inn By Marriott St. Louis Clayton](https://www.expedia.co.uk/St-Louis-Hotels-Residence-Inn-By-Marriott-St-Louis-Clayton.h90176307.Hotel-Information) ![A rooftop terrace with a fire feature, outdoor seating, and a city view.](https://images.trvl-media.com/lodging/91000000/90180000/90176400/90176307/1d5977f2.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) - Location: Clayton - Review: Very nice clean long stay hotel. Easy parking and great staff Thank you, by nevil, 12 March 2026, rated 10/10 Excellent ### [Four Seasons Hotel St Louis](https://www.expedia.co.uk/St-Louis-Hotels-Four-Seasons-Hotel-St-Louis.h2851438.Hotel-Information) ![A modern hotel lobby with a glass facade, seating area, and a staircase.](https://images.trvl-media.com/lodging/3000000/2860000/2851500/2851438/ef7a5612.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) - Location: Downtown St. Louis - Review: Connected to a casino that is rough and smells of cigarettes, by Alethea, 12 March 2025, rated 10/10 Excellent ### [TownePlace Suites by Marriott Brentwood](https://www.expedia.co.uk/St-Louis-Hotels-TownePlace-Suites-By-Marriott-Brentwood.h69369014.Hotel-Information) ![An outdoor patio with a stone fire pit, wicker furniture, and a wooden pergola.](https://images.trvl-media.com/lodging/70000000/69370000/69369100/69369014/5acbf31e.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) - Location: Brentwood - Review: Nice, by jonathan, 10 November 2024, rated 10/10 Excellent ### [AC Hotel St. Louis Clayton](https://www.expedia.co.uk/St-Louis-Hotels-Ac-Hotel-By-Marriott-St-Louis-Clayton.h105374473.Hotel-Information) ![A rooftop terrace with modern outdoor seating, a fire pit, and a view of the cityscape.](https://images.trvl-media.com/lodging/106000000/105380000/105374500/105374473/837b161d.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) - Location: Clayton - Review: Friendly staff, by Theodore, 17 April 2025, rated 8/10 Good ### [Pear Tree Inn St. Louis Airport](https://www.expedia.co.uk/St-Louis-Hotels-Pear-Tree-Inn-St-Louis-Airport.h1096579.Hotel-Information) ![A spacious lobby with modern seating, a reception desk, and large windows offering views of the parking area.](https://images.trvl-media.com/lodging/2000000/1100000/1096600/1096579/fc156cf2.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) - Address: 10810 Pear Tree Ln, St. Ann, MO, 63074, US - Location: St. Ann - Star rating: 2.5/5 - Guest rating: 9.4/10 (3362 reviews) - Review: Every thing was really good from shuttle to check out staf where amazing, and plenty to choose from for breakfast, by Stephen, 2 May 2026, rated 10/10 Excellent ## Frequently Asked Questions ### What's the area like around St. Louis Science Center? St. Louis Science Center is located in a welcoming area of St. Louis known for its picturesque gardens and sporting events. If you're looking for a convenient place to stay, take a look at the 74 hotels and other accommodation options you'll find within a mile. ### What's the best hotel to stay near St. Louis Science Center? [Hampton Inn & Suites St. Louis at Forest Park](https://www.expedia.co.uk/St-Louis-Hotels-Hampton-Inn-Suites-St-Louis-At-Forest-Park.h1427801.Hotel-Information) is one of the top choices for your stay based on our traveller data, and this hotel offers free breakfast and an indoor pool. It's located just a short 0.6 mi (1 km) from St. Louis Science Center. Other good choices within a short distance include [Home2 Suites by Hilton St. Louis/Forest Park](https://www.expedia.co.uk/St-Louis-Hotels-Home2-Suites-By-Hilton-St-LouisForest-Park.h10503041.Hotel-Information) and [DoubleTree by Hilton St. Louis Forest Park](https://www.expedia.co.uk/St-Louis-Hotels-DoubleTree-By-Hilton-St-Louis-Forest-Park.h1082373.Hotel-Information). ### How many hotels should I expect to find close to St. Louis Science Center? Expedia has 74 hotels and other accommodation options within a mile from St. Louis Science Center. ### If I need to cancel the hotel reservation for my stay near St. Louis Science Center, will I receive a refund? Yes, most hotel room reservations are refundable if you cancel prior to the hotel's cancellation deadline, which is usually within 24-48 hours of your scheduled arrival. If you have a non-refundable reservation, you may still be able to cancel and receive a refund within 24 hours of booking. Plug in your dates, click on "Search", then you can filter by "fully refundable" to review the best deals near St. Louis Science Center. ### What can I see and do near St. Louis Science Center? Cathedral Basilica of St. Louis, St. Louis Art Museum and City Museum feature captivating exhibits. St. Louis Union Station, Jewel Box and Cherokee Street are monuments to see when you're exploring the area around St. Louis Science Center. You can check out the local talent at The Muny Theater, Fox Theater and St. Louis Symphony Orchestra. ## Other language versions ```yaml hreflang: x-default: https://www.expedia.com/St-Louis-Science-Center-Hotels.0-l502861-0.Travel-Guide-Filter-Hotels zh-CN: https://www.expedia.com/cn/St-Louis-Science-Center-Hotels.0-l502861-0.Travel-Guide-Filter-Hotels en-HK: https://www.expedia.com.hk/en/St-Louis-Science-Center-Hotels.0-l502861-0.Travel-Guide-Filter-Hotels es: https://www.expedia.com/es/St-Louis-Science-Center-Hoteles.0-l502861-0.Guia-Viajes-Filter-Hoteles en-US: https://www.expedia.com/St-Louis-Science-Center-Hotels.0-l502861-0.Travel-Guide-Filter-Hotels en-TW: https://www.expedia.com.tw/en/St-Louis-Science-Center-Hotels.0-l502861-0.Travel-Guide-Filter-Hotels ko-KR: https://www.expedia.co.kr/St-Louis-Science-Center-Hotels.0-l502861-0.Travel-Guide-Filter-Hotels ar: https://www.expedia.sa/St-Louis-Science-Center-Hotels.0-l502861-0.Travel-Guide-Filter-Hotels es-MX: https://www.expedia.mx/St-Louis-Science-Center-Hoteles.0-l502861-0.Guia-Viajes-Filter-Hoteles nb-NO: https://www.expedia.no/St-Louis-Vitenskapssenter-Hoteller.0-l502861-0.Reise-Guide-Filter-Hoteller sv-SE: https://www.expedia.se/St-Louis-Science-Center-Hotell.0-l502861-0.Reseguide-Filter-Hotell en-CA: https://www.expedia.ca/St-Louis-Science-Center-Hotels.0-l502861-0.Travel-Guide-Filter-Hotels ```