Title: TOP Hotels near Museums in South San Diego, CA for 2026 | Expedia.co.uk [South San Diego Travel Guide](https://expedia.co.uk/South-San-Diego.dx553248632063518562)[Hotels in South San Diego](https://expedia.co.uk/South-San-Diego-Hotels.d553248632063518562.Travel-Guide-Hotels)[Holiday Rentals in South San Diego](https://expedia.co.uk/South-San-Diego-Holiday-Rentals.d553248632063518562.Travel-Guide-HolidayRentals)[Flights to South San Diego](https://expedia.co.uk/Cheap-Flights-To-South-San-Diego.d553248632063518562.Travel-Guide-Flights)[Things to do in South San Diego](https://expedia.co.uk/Things-To-Do-In-South-San-Diego.d553248632063518562.Travel-Guide-Activities)[South San Diego Car Hire](https://expedia.co.uk/Compare-Cheap-Car-Hire-In-South-San-Diego.d553248632063518562.Car-Hire-Guide)[South San Diego Holidays](https://expedia.co.uk/South-San-Diego.d553248632063518562.Holidays-City-Breaks) ![Captured this guy doing a wheelie during a beautiful sunset! #imperialbeach #EndlessSummer #autographhotels #Marriott #piersouthresort](https://images.trvl-media.com/place/177683/d4a8a1a3-bd23-4c6a-826e-e0c1c12dddaa.jpg?impolicy=fcrop&w=1200&h=500&q=medium) Photo by Karen Leone ![](https://images.trvl-media.com/place/177683/d4a8a1a3-bd23-4c6a-826e-e0c1c12dddaa.jpg?impolicy=fcrop&w=1200&h=500&q=medium) - ![](https://a.travel-assets.com/travel-assets-manager/pictogram-bex/light__price_find.svg) ### Change your mind Book hotels with free cancellation - ![](https://a.travel-assets.com/travel-assets-manager/pictogram-bex/light__deals.svg) ### Treat yourself Save instantly and earn perks with One Key [Learn about One Key](https://www.expedia.co.uk/welcome-one-key) - ![](https://a.travel-assets.com/travel-assets-manager/pictogram-bex/light__bed.svg) ### Be picky Search almost a million properties worldwide ## Check availability on South San Diego Hotels near Museums Tonight [12 Feb - 13 Feb](https://www.expedia.co.uk/Hotel-Search?regionId=553248632063518562&startDate=2026-02-12&endDate=2026-02-13&adults=2&rfrr=TG.LP.CheckPrices.Hotel&openPlayBack=true) Tomorrow [13 Feb - 14 Feb](https://www.expedia.co.uk/Hotel-Search?regionId=553248632063518562&startDate=2026-02-13&endDate=2026-02-14&adults=2&rfrr=TG.LP.CheckPrices.Hotel&openPlayBack=true) This weekend [13 Feb - 15 Feb](https://www.expedia.co.uk/Hotel-Search?regionId=553248632063518562&startDate=2026-02-13&endDate=2026-02-15&adults=2&rfrr=TG.LP.CheckPrices.Hotel&openPlayBack=true) Next weekend [20 Feb - 22 Feb](https://www.expedia.co.uk/Hotel-Search?regionId=553248632063518562&startDate=2026-02-20&endDate=2026-02-22&adults=2&rfrr=TG.LP.CheckPrices.Hotel&openPlayBack=true) No exact matches found, but these alternatives could be just right ## Recommended hotels in South San Diego ![Reception](https://images.trvl-media.com/lodging/121000000/120560000/120554700/120554667/1263373a.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Premium Quadruple Room, 2 Queen Beds, Non Smoking | Desk, laptop workspace, free WiFi, bed sheets](https://images.trvl-media.com/lodging/121000000/120560000/120554700/120554667/c6033e56.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Front of property](https://images.trvl-media.com/lodging/121000000/120560000/120554700/120554667/179e83f6.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Exterior](https://images.trvl-media.com/lodging/121000000/120560000/120554700/120554667/1f027e84.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ### BORDER PLAZA HOTEL [](https://www.expedia.co.uk/San-Ysidro-Hotels-BORDER-PLAZA-HOTEL.h120554667.Hotel-Information) San Ysidro 7.4/10 Good (91 reviews) "Nice quiet place to stay at and walking distance to border." ![United States](https://a.travel-assets.com/egds/marks/flags/us.svg) Victor £63 includes taxes & fees 24 Feb - 25 Feb [](https://www.expedia.co.uk/San-Ysidro-Hotels-BORDER-PLAZA-HOTEL.h120554667.Hotel-Information) ![Deluxe Room, 2 Queen Beds, Non Smoking | Free WiFi, bed sheets](https://images.trvl-media.com/lodging/110000000/109310000/109303200/109303139/15a8b45d.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Free WiFi, bed sheets](https://images.trvl-media.com/lodging/110000000/109310000/109303200/109303139/e3b4ebcc.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Shower, towels, soap, shampoo](https://images.trvl-media.com/lodging/110000000/109310000/109303200/109303139/435ce843.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Outdoor pool](https://images.trvl-media.com/lodging/110000000/109310000/109303200/109303139/39af12d5.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ### ERTH INN by AGA- San Ysidro [](https://www.expedia.co.uk/San-Ysidro-Hotels-Flamingo-Motel.h109303139.Hotel-Information) San Ysidro 8.0/10 Very good (67 reviews) "Very relaxing stay, quiet, and clean" ![United States](https://a.travel-assets.com/egds/marks/flags/us.svg) Victor £54 includes taxes & fees 15 Mar - 16 Mar [](https://www.expedia.co.uk/San-Ysidro-Hotels-Flamingo-Motel.h109303139.Hotel-Information) ![Lobby](https://images.trvl-media.com/lodging/1000000/810000/806400/806327/025fd645.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Standard Room, 1 Queen Bed, Non Smoking, Refrigerator & Microwave | Pillow-top beds, in-room safe, desk, laptop workspace](https://images.trvl-media.com/lodging/1000000/810000/806400/806327/44f8822a.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Business centre](https://images.trvl-media.com/lodging/1000000/810000/806400/806327/2ba90811.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Exterior](https://images.trvl-media.com/lodging/1000000/810000/806400/806327/bb54a734.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ### Best Western Americana Inn [](https://www.expedia.co.uk/San-Ysidro-Hotels-Best-Western-Americana-Inn.h806327.Hotel-Information) San Ysidro 8.8/10 Excellent (1,225 reviews) "Great stay" ![United States](https://a.travel-assets.com/egds/marks/flags/us.svg) Elisa £96 includes taxes & fees 18 Feb - 19 Feb [](https://www.expedia.co.uk/San-Ysidro-Hotels-Best-Western-Americana-Inn.h806327.Hotel-Information) ![Lobby](https://images.trvl-media.com/lodging/1000000/60000/57300/57235/23d13d0b.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Exterior](https://images.trvl-media.com/lodging/1000000/60000/57300/57235/12575691.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Lobby sitting area](https://images.trvl-media.com/lodging/1000000/60000/57300/57235/e6d210ec.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Vending machine](https://images.trvl-media.com/lodging/1000000/60000/57300/57235/a024d7fd.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ### Motel 6 San Ysidro, CA - San Diego - Border [](https://www.expedia.co.uk/San-Ysidro-Hotels-Motel-6-San-Ysidro.h57235.Hotel-Information) San Ysidro 7.2/10 Good (1,476 reviews) "Easy acces to restsurant" ![United States](https://a.travel-assets.com/egds/marks/flags/us.svg) JOSE £57 includes taxes & fees 16 Feb - 17 Feb [](https://www.expedia.co.uk/San-Ysidro-Hotels-Motel-6-San-Ysidro.h57235.Hotel-Information) ![Free on-the-go breakfast ](https://images.trvl-media.com/lodging/1000000/470000/461900/461837/bd6623c1.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Suite, 2 Queen Beds, Non Smoking | Desk, laptop workspace, blackout curtains, iron/ironing board](https://images.trvl-media.com/lodging/1000000/470000/461900/461837/70282182.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Desk, laptop workspace, blackout curtains, iron/ironing board](https://images.trvl-media.com/lodging/1000000/470000/461900/461837/55248c07.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Lobby](https://images.trvl-media.com/lodging/1000000/470000/461900/461837/586d04dd.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ### Quality Suites San Diego Otay Mesa [](https://www.expedia.co.uk/San-Diego-Hotels-Quality-Suites-San-Diego-Otay-Mesa.h461837.Hotel-Information) Otay Mesa 7.0/10 Good (1,000 reviews) "Great staff.. location close to the airport!" ![United States](https://a.travel-assets.com/egds/marks/flags/us.svg) Vivian £83 includes taxes & fees 15 Feb - 16 Feb [](https://www.expedia.co.uk/San-Diego-Hotels-Quality-Suites-San-Diego-Otay-Mesa.h461837.Hotel-Information) ![Coffee/tea maker](https://images.trvl-media.com/lodging/2000000/1800000/1798100/1798071/18bcfb40.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Desk, blackout curtains, iron/ironing board, free WiFi](https://images.trvl-media.com/lodging/2000000/1800000/1798100/1798071/b359fdeb.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Reception](https://images.trvl-media.com/lodging/2000000/1800000/1798100/1798071/58b6effd.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Outdoor pool](https://images.trvl-media.com/lodging/2000000/1800000/1798100/1798071/e796672a.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ### Studio 6 Suites San Ysidro, CA -San Diego South Bay [](https://www.expedia.co.uk/San-Ysidro-Hotels-Knights-Inn-San-Ysidro.h1798071.Hotel-Information) San Ysidro 7.8/10 Good (1,496 reviews) "The staff was nice " ![United States](https://a.travel-assets.com/egds/marks/flags/us.svg) Claudia £55 includes taxes & fees 26 Feb - 27 Feb [](https://www.expedia.co.uk/San-Ysidro-Hotels-Knights-Inn-San-Ysidro.h1798071.Hotel-Information) ![Terrace/patio](https://images.trvl-media.com/lodging/50000000/49290000/49284700/49284697/w3836h2556x3y3-467b2b48.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![49-inch flat-screen TV with cable channels, TV](https://images.trvl-media.com/lodging/50000000/49290000/49284700/49284697/w3830h2553x4y4-0f56bb42.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Lobby](https://images.trvl-media.com/lodging/50000000/49290000/49284700/49284697/w3839h2555x0y3-5f9fe6e4.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Exterior](https://images.trvl-media.com/lodging/50000000/49290000/49284700/49284697/e9cd53ec.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ### Hampton Inn & Suites Imperial Beach San Diego [](https://www.expedia.co.uk/Imperial-Beach-Hotels-Hampton-Inn-Suites-Imperial-Beach-San-Diego.h49284697.Hotel-Information) Imperial Beach 9.4/10 Exceptional (989 reviews) "It’s always a great place to stay. The staff are so nice and friendly, rooms are very nice." ![United States](https://a.travel-assets.com/egds/marks/flags/us.svg) Carolyn £135 includes taxes & fees 22 Feb - 23 Feb [](https://www.expedia.co.uk/Imperial-Beach-Hotels-Hampton-Inn-Suites-Imperial-Beach-San-Diego.h49284697.Hotel-Information) ![Exterior](https://images.trvl-media.com/lodging/35000000/34910000/34909900/34909853/7aa1b6a7.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Combined shower/bathtub, towels](https://images.trvl-media.com/lodging/35000000/34910000/34909900/34909853/1d8aba96.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Desk, blackout curtains, soundproofing, free WiFi](https://images.trvl-media.com/lodging/35000000/34910000/34909900/34909853/06274c72.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Premium Room, 2 Double Beds, Non Smoking | Desk, blackout curtains, soundproofing, free WiFi](https://images.trvl-media.com/lodging/35000000/34910000/34909900/34909853/9072a14b.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ### Valli Hi Motel [](https://www.expedia.co.uk/San-Ysidro-Hotels-Valli-Hi-Motel.h34909853.Hotel-Information) San Ysidro 8.4/10 Very good (1,000 reviews) "We stay here when we have an early flight out of Tijuana - convenient to the cbx border crossing " ![United States](https://a.travel-assets.com/egds/marks/flags/us.svg) sergio [](https://www.expedia.co.uk/San-Ysidro-Hotels-Valli-Hi-Motel.h34909853.Hotel-Information) ![Free continental breakfast ](https://images.trvl-media.com/lodging/1000000/30000/22900/22810/079ae4ce.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Exterior](https://images.trvl-media.com/lodging/1000000/30000/22900/22810/bfd1ccfe.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Standard Room, 2 Double Beds, Non Smoking | Premium bedding, desk, iron/ironing board, free cots/infant beds](https://images.trvl-media.com/lodging/1000000/30000/22900/22810/4e7175aa.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Property amenity](https://images.trvl-media.com/lodging/1000000/30000/22900/22810/83180011.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ### La Quinta Inn by Wyndham San Diego Chula Vista [](https://www.expedia.co.uk/Chula-Vista-Hotels-La-Quinta-Inn-By-Wyndham-San-Diego-Chula-Vista.h22810.Hotel-Information) Chula Vista 8.6/10 Excellent (1,534 reviews) "The room was very clean and the staff was very nice." ![United States](https://a.travel-assets.com/egds/marks/flags/us.svg) Rod £77 includes taxes & fees 1 Mar - 2 Mar [](https://www.expedia.co.uk/Chula-Vista-Hotels-La-Quinta-Inn-By-Wyndham-San-Diego-Chula-Vista.h22810.Hotel-Information) ![Free buffet breakfast ](https://images.trvl-media.com/lodging/2000000/1640000/1632400/1632358/3f975189.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Outdoor pool](https://images.trvl-media.com/lodging/2000000/1640000/1632400/1632358/1779e3cc.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Free buffet breakfast ](https://images.trvl-media.com/lodging/2000000/1640000/1632400/1632358/242d8336.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![In-room safe, desk, iron/ironing board, free WiFi](https://images.trvl-media.com/lodging/2000000/1640000/1632400/1632358/a1b42446.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ### Holiday Inn Express Hotel & Suites San Diego Otay Mesa by IHG [](https://www.expedia.co.uk/San-Diego-Hotels-Holiday-Inn-Express-Hotel-Suites-San-Diego-Otay-Mesa.h1632358.Hotel-Information) Otay Mesa 8.0/10 Very good (1,641 reviews) "Clean, great breakfast, good service." ![United States](https://a.travel-assets.com/egds/marks/flags/us.svg) Sara £108 includes taxes & fees 8 Mar - 9 Mar [](https://www.expedia.co.uk/San-Diego-Hotels-Holiday-Inn-Express-Hotel-Suites-San-Diego-Otay-Mesa.h1632358.Hotel-Information) Lowest nightly price found within the past 24 hours based on a 1 night stay for 2 adults. Prices and availability subject to change. Additional terms may apply. [View all properties](https://expedia.co.uk/Hotel-Search?startDate=2026-02-26&endDate=2026-02-27®ionId=553248632063518562&adults=2&location_highlights_explore=museums&sort=RECOMMENDED&openPlayBack=true) ![](https://forever.travel-assets.com/flex/flexmanager/images/2026/02/06/expedia-sale-2026-desktop-uk-fr-de.jpg?impolicy=fcrop&w=1400&h=600&q=mediumHigh) ## The Annual Holiday Sale Members save up to 40% on hotels and holiday homes. Plan this year’s big trip and save. [Book now](https://expedia.co.uk/cheap-deals?rfrr=AFFINITY_SPRING_PROMO_553248632063518562) ## Top South San Diego Hotel Reviews ![Hard Rock Hotel San Diego](https://images.trvl-media.com/lodging/2000000/1740000/1731600/1731557/fbbdfc57_y.jpg) ### Hard Rock Hotel San Diego 10/10 Excellent "Great stay" [](https://expedia.co.uk/San-Diego-Hotels-Hard-Rock-Hotel-San-Diego.h1731557.Hotel-Information) ![Paradise Point Resort & Spa](https://images.trvl-media.com/lodging/1000000/10000/3800/3731/bc1e5add_y.jpg) ### Paradise Point Resort & Spa 10/10 Excellent "Spotless" [](https://expedia.co.uk/San-Diego-Hotels-Paradise-Point-Resort-Spa.h3731.Hotel-Information) ![Wyndham San Diego Bayside](https://images.trvl-media.com/lodging/1000000/20000/11200/11177/c44ff51d_y.jpg) ### Wyndham San Diego Bayside 10/10 Excellent "For some free drinks " [](https://expedia.co.uk/San-Diego-Hotels-Wyndham-San-Diego-Bayside.h11177.Hotel-Information) ![The Sofia Hotel](https://images.trvl-media.com/lodging/2000000/1580000/1573900/1573807/ba6cea84_y.jpg) ### The Sofia Hotel 10/10 Excellent "Fantastic location. It is just 10 mins walk to 5th avenue, 15 mins walk to the Portside pier, and the same distance to Little Italy. " [](https://expedia.co.uk/San-Diego-Hotels-The-Sofia-Hotel.h1573807.Hotel-Information) ![The DEXTRO Little Italy, BW Premier Collection](https://images.trvl-media.com/lodging/1000000/180000/170400/170338/6fe441dd_y.jpg) ### The DEXTRO Little Italy, BW Premier Collection 10/10 Excellent "Clean room and available a few hours earlier than normal check in! Room was spacious and staff was great! " [](https://expedia.co.uk/San-Diego-Hotels-Four-Points-By-Sheraton-San-Diego-Downtown-Little-Italy.h170338.Hotel-Information) ![Sheraton San Diego Resort](https://images.trvl-media.com/lodging/1000000/20000/11200/11109/w4000h2662x0y0-91d299a1_y.jpg) ### Sheraton San Diego Resort 10/10 Excellent "Great " [](https://expedia.co.uk/San-Diego-Hotels-Sheraton-San-Diego-Resort.h11109.Hotel-Information) ![Humphreys Half Moon Inn](https://images.trvl-media.com/lodging/1000000/40000/36200/36183/7cb5b7d9_y.jpg) ### Humphreys Half Moon Inn 10/10 Excellent "The rooms were very comfortable and clean." [](https://expedia.co.uk/San-Diego-Hotels-Humphreys-Half-Moon-Inn.h36183.Hotel-Information) ![Days Inn by Wyndham San Diego Hotel Circle](https://images.trvl-media.com/lodging/1000000/20000/19300/19220/3334d773_y.jpg) ### Days Inn by Wyndham San Diego Hotel Circle 10/10 Excellent "Clean updated rooms " [](https://expedia.co.uk/San-Diego-Hotels-Days-Inn-By-Wyndham-San-Diego-Hotel-Circle.h19220.Hotel-Information) ![Bay Club Hotel & Marina](https://images.trvl-media.com/lodging/1000000/10000/2600/2514/8c022c3d_y.jpg) ### Bay Club Hotel & Marina 10/10 Excellent "Yes clean" [](https://expedia.co.uk/San-Diego-Hotels-Bay-Club-Hotel-Marina.h2514.Hotel-Information) ## Explore a world of travel with Expedia - Accommodation - Flights - Packages - Cars - Holiday Homes - Other - [Sports Hotels in Anaheim ](https://www.expedia.co.uk/Anaheim-Hotels-Adventure-Sport-Hotel.0-0-d5921-tAdventureSportHotel.Travel-Guide-Filter-Hotels) - [Business Hotels in Anaheim ](https://www.expedia.co.uk/Anaheim-Hotels-Business-Hotel.0-0-d5921-tBusinessHotel.Travel-Guide-Filter-Hotels) - 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