Title: The Best Hotels Closest to Sanford Vermillion Medical Center in Vermillion - 2026 Updated Prices | Expedia.co.uk [Vermillion Travel Guide](https://expedia.co.uk/Vermillion.dx6139371)[Holiday Rentals in Vermillion](https://expedia.co.uk/Vermillion-Holiday-Rentals.d6139371.Travel-Guide-HolidayRentals)[Flights to Vermillion](https://expedia.co.uk/Cheap-Flights-To-Vermillion.d6139371.Travel-Guide-Flights)[Sanford Vermillion Medical Center Car Hire](https://expedia.co.uk/Compare-Cheap-Car-Hire-In-Sanford-Vermillion-Medical-Center.d624553634426589184.Car-Hire-Guide)[Sanford Vermillion Medical Center Holidays](https://expedia.co.uk/Sanford-Vermillion-Medical-Center-Vermillion.d624553634426589184.Attraction) ![Default HTG hotel image](https://a.travel-assets.com/travel-assets-manager/fallback-images-brand/bex_lodging_v2.jpg?impolicy=fcrop&w=1200&h=500&q=medium) ![](https://a.travel-assets.com/travel-assets-manager/fallback-images-brand/bex_lodging_v2.jpg?impolicy=fcrop&w=1200&h=500&q=medium) - ![](https://a.travel-assets.com/travel-assets-manager/pictogram-bex/light__price_find.svg) ### Change your mind Book hotels with free cancellation - ![](https://a.travel-assets.com/travel-assets-manager/pictogram-bex/light__deals.svg) ### Treat yourself Save instantly and earn perks with One Key [Learn about One Key](https://www.expedia.co.uk/welcome-one-key) - ![](https://a.travel-assets.com/travel-assets-manager/pictogram-bex/light__bed.svg) ### Be picky Search almost a million properties worldwide ## Check prices for these dates Tonight [11 Feb - 12 Feb](https://www.expedia.co.uk/Hotel-Search?regionId=624553634426589184&startDate=2026-02-11&endDate=2026-02-12&adults=2&rfrr=TG.LP.CheckPrices.Hotel&openPlayBack=true) Tomorrow [12 Feb - 13 Feb](https://www.expedia.co.uk/Hotel-Search?regionId=624553634426589184&startDate=2026-02-12&endDate=2026-02-13&adults=2&rfrr=TG.LP.CheckPrices.Hotel&openPlayBack=true) This weekend [13 Feb - 15 Feb](https://www.expedia.co.uk/Hotel-Search?regionId=624553634426589184&startDate=2026-02-13&endDate=2026-02-15&adults=2&rfrr=TG.LP.CheckPrices.Hotel&openPlayBack=true) Next weekend [20 Feb - 22 Feb](https://www.expedia.co.uk/Hotel-Search?regionId=624553634426589184&startDate=2026-02-20&endDate=2026-02-22&adults=2&rfrr=TG.LP.CheckPrices.Hotel&openPlayBack=true) Recommended Price (low to high) Distance Property class ## Our top choices for Sanford Vermillion Medical Center hotels ![Exterior](https://images.trvl-media.com/lodging/1000000/20000/15800/15762/bd21164c.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Lobby](https://images.trvl-media.com/lodging/1000000/20000/15800/15762/5ee6f3dc.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Suite, 1 Queen Bed, Non Smoking, Kitchenette (with Sofabed) | In-room safe, laptop workspace, iron/ironing board, WiFi](https://images.trvl-media.com/lodging/1000000/20000/15800/15762/f83f2377.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Indoor pool](https://images.trvl-media.com/lodging/1000000/20000/15800/15762/d661cf05.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ### Best Western Vermillion Inn [](https://www.expedia.co.uk/Vermillion-Hotels-Best-Western-Vermillion-Inn.h15762.Hotel-Information) 1.3 mi from Sanford Vermillion Medical Center 8.6/10 Excellent (567 reviews) "Clean rooms and friendly and helpful staff" ![United States](https://a.travel-assets.com/egds/marks/flags/us.svg) Russell £78 includes taxes & fees 18 Feb - 19 Feb [](https://www.expedia.co.uk/Vermillion-Hotels-Best-Western-Vermillion-Inn.h15762.Hotel-Information) ![Indoor pool](https://images.trvl-media.com/lodging/13000000/12330000/12324700/12324671/ef86d63e.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Hallway](https://images.trvl-media.com/lodging/13000000/12330000/12324700/12324671/195256fb.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Deluxe Room, 2 Queen Beds (Smoke Free) | Premium bedding, desk, rollaway beds, free WiFi](https://images.trvl-media.com/lodging/13000000/12330000/12324700/12324671/a1eea5dc.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Café](https://images.trvl-media.com/lodging/13000000/12330000/12324700/12324671/022f2547.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ### Red Roof Inn Vermillion - U of South Dakota [](https://www.expedia.co.uk/Vermillion-Hotels-Red-Roof-Inn-Vermillion-U-Of-South-Dakota.h12324671.Hotel-Information) 0.6 mi from Sanford Vermillion Medical Center 8.0/10 Very good (432 reviews) "Yes having a great stay" ![United States](https://a.travel-assets.com/egds/marks/flags/us.svg) earl £64 includes taxes & fees 12 Feb - 13 Feb [](https://www.expedia.co.uk/Vermillion-Hotels-Red-Roof-Inn-Vermillion-U-Of-South-Dakota.h12324671.Hotel-Information) ![Exterior](https://images.trvl-media.com/lodging/1000000/90000/85000/84959/d7b72b3b.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Café](https://images.trvl-media.com/lodging/1000000/90000/85000/84959/72f7ed06.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Reception](https://images.trvl-media.com/lodging/1000000/90000/85000/84959/41c09b2c.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Lobby sitting area](https://images.trvl-media.com/lodging/1000000/90000/85000/84959/27100b5d.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ### Prairie Inn [](https://www.expedia.co.uk/Vermillion-Hotels-Prairie-Inn.h84959.Hotel-Information) 1 mi from Sanford Vermillion Medical Center 7.2/10 Good (337 reviews) "hot shower, clean room, bed to sleep on, food in morning, 10/10" ![United States](https://a.travel-assets.com/egds/marks/flags/us.svg) Gregory £61 includes taxes & fees 11 Mar - 12 Mar [](https://www.expedia.co.uk/Vermillion-Hotels-Prairie-Inn.h84959.Hotel-Information) Lowest nightly price found within the past 24 hours based on a 1 night stay for 2 adults. Prices and availability subject to change. Additional terms may apply. [View all properties](https://expedia.co.uk/Hotel-Search?startDate=2026-02-25&endDate=2026-02-26®ionId=624553634426589184&adults=2&sort=RECOMMENDED&openPlayBack=true) ## Top Sanford Vermillion Medical Center Hotel Reviews ![Prairie Inn](https://images.trvl-media.com/lodging/1000000/90000/85000/84959/0d847b4d_y.jpg) ### Prairie Inn 10/10 Excellent "Friendly staff, close to campus, warm bed and hot shower. I was traveling with a dog and they put me in a room on the first floor right by an exit door which was wonderful" [](https://expedia.co.uk/Vermillion-Hotels-Prairie-Inn.h84959.Hotel-Information) ![Best Western Kelly Inn](https://images.trvl-media.com/lodging/7000000/6850000/6847000/6846956/2110bd4e_y.jpg) ### Best Western Kelly Inn 10/10 Excellent "Very friendly staff!! " [](https://expedia.co.uk/Vermillion-Hotels-Best-Western-Kelly-Inn.h6846956.Hotel-Information) ![Red Roof Inn Vermillion - U of South Dakota](https://images.trvl-media.com/lodging/13000000/12330000/12324700/12324671/76b36c76_y.jpg) ### Red Roof Inn Vermillion - U of South Dakota 10/10 Excellent "Room was clean and ready for check in. Staff was great. Only complaints were the pool area was locked and was being used for storage and vending machine was out of order." [](https://expedia.co.uk/Vermillion-Hotels-Red-Roof-Inn-Vermillion-U-Of-South-Dakota.h12324671.Hotel-Information) ![Cobblestone Inn & Suites - Hartington](https://images.trvl-media.com/lodging/7000000/6260000/6257700/6257625/a297652c_y.jpg) ### Cobblestone Inn & Suites - Hartington 10/10 Excellent "Very clean and comfortable hotel. Friendly family owned property!" [](https://expedia.co.uk/Hartington-Hotels-Cobblestone-Inn-Suites-Hartington.h6257625.Hotel-Information) ![Best Western Vermillion Inn](https://images.trvl-media.com/lodging/1000000/20000/15800/15762/3f1d7496_y.jpg) ### Best Western Vermillion Inn 10/10 Excellent "Yes " [](https://expedia.co.uk/Vermillion-Hotels-Best-Western-Vermillion-Inn.h15762.Hotel-Information) ![Holiday Inn Express Hotel & Suites Vermillion by IHG](https://images.trvl-media.com/lodging/2000000/1050000/1046300/1046236/9e2d34e9_y.jpg) ### Holiday Inn Express Hotel & Suites Vermillion by IHG 10/10 Excellent "Clean room " [](https://expedia.co.uk/Vermillion-Hotels-Holiday-Inn-Express-Hotel-Suites-Vermillion.h1046236.Hotel-Information) ![Quiet Tiny House in the Country](https://images.trvl-media.com/lodging/120000000/119700000/119691600/119691573/187ca61b_y.jpg) ### Quiet Tiny House in the Country 10/10 Excellent "Beautiful and quiet place. Clean and accommodating. " [](https://expedia.co.uk/Ponca-Hotels-Quiet-Tiny-House-In-The-Country.h119691573.Hotel-Information) ![Bohemian 3-bedroom house with private yard in charming neighborhood](https://images.trvl-media.com/lodging/110000000/109500000/109498600/109498585/5e2a4e6e_y.jpg) ### Bohemian 3-bedroom house with private yard in charming neighborhood 10/10 Excellent "Very cute and clean place. It had everything you would need. " [](https://expedia.co.uk/Vermillion-Hotels-Bohemian-3-Bedroom-House-With-Private-Yard-In-Charming-Neighborhood.h109498585.Hotel-Information) ![Cozy RV with Expansive River Views](https://images.trvl-media.com/lodging/114000000/113300000/113293900/113293847/6c7b9302_y.jpg) ### Cozy RV with Expansive River Views 10/10 Excellent "Pet friendly, nice place to stay beautiful views, accommodating. overall great trip, would come back! Blackstone grill was amazing to make breakfast on, camper had everything we needed! " [](https://expedia.co.uk/Newcastle-Hotels-Cozy-RV-With-Expansive-River-Views.h113293847.Hotel-Information) ## Hotels near other Sanford Vermillion Medical Center attractions ![Russian musical instrument gusli](https://images.trvl-media.com/place/553248621532648841/c0a08316-de49-4577-ba80-0a19c1d66874.jpg) ### National Music Museum 3.9/5 (8 reviews) You can spend time browsing the exhibits at National Music Museum during your trip to Vermillion. While in this family-friendly area, you can savour the bars and restaurants. [See properties](https://www.expedia.co.uk/Hotel-Search?rfrrid=TG.LP..PointOfInterests®ionId=553248621532648841) ![Beautiful day on a beautiful campus.](https://images.trvl-media.com/place/6139371/3efbec90-0805-455e-b110-310b928e7894.jpg) Photo by Jody Klein ### University of South Dakota 4.5/5 (62 reviews) Enjoy the student vibe when you visit University of South Dakota during your trip to Vermillion. While in this family-friendly area, you can savour the bars and restaurants. [See properties](https://www.expedia.co.uk/Hotel-Search?rfrrid=TG.LP..PointOfInterests®ionId=6090973) ### Austin-Whittemore House You can spend an afternoon browsing the exhibits at Austin-Whittemore House in Vermillion. While in this family-friendly area, you can savour the bars and restaurants. [See properties](https://www.expedia.co.uk/Hotel-Search?rfrrid=TG.LP..PointOfInterests®ionId=949599879896977408) ### Sanford Coyote Sports Center Catch an event at Sanford Coyote Sports Center during your trip to Vermillion. While in this family-friendly area, you can savour the bars and restaurants. [See properties](https://www.expedia.co.uk/Hotel-Search?rfrrid=TG.LP..PointOfInterests®ionId=693563081172291584) ### The Bluffs Golf Course 3.6/5 (8 reviews) Enjoy a round of golf in Vermillion at The Bluffs Golf Course. While in this family-friendly area, you can savour the bars and restaurants. [See properties](https://www.expedia.co.uk/Hotel-Search?rfrrid=TG.LP..PointOfInterests®ionId=553248621565118560) ### W. H. Over Museum You can spend an afternoon browsing the exhibits at W. H. Over Museum during your trip to Vermillion. While in this family-friendly area, you can savour the bars and restaurants. [See properties](https://www.expedia.co.uk/Hotel-Search?rfrrid=TG.LP..PointOfInterests®ionId=722426260156022784) ### DakotaDome 4.8/5 (10 reviews) Catch an event at DakotaDome during your trip to Vermillion. While in this family-friendly area, you can savour the bars and restaurants. [See properties](https://www.expedia.co.uk/Hotel-Search?rfrrid=TG.LP..PointOfInterests®ionId=553248635997928317) ### Barstow Park 4.7/5 (3 reviews) Barstow Park is just one of the places to see in Vermillion, so why not enjoy the other things to explore during your travels? While in this family-friendly area, you can savour the bars and restaurants. [See properties](https://www.expedia.co.uk/Hotel-Search?rfrrid=TG.LP..PointOfInterests®ionId=553248621565118561) ## Frequently asked questions ### What's the area like around Sanford Vermillion Medical Center? ### What's the best place to stay close to Sanford Vermillion Medical Center? ### How many hotels will I find near Sanford Vermillion Medical Center? ### If I need to cancel the hotel reservation for my stay near Sanford Vermillion Medical Center, will I receive a refund? ### What can I see and do near Sanford Vermillion Medical Center?