Title: The Best Hotels in Medical Center District, San Antonio - 2026 Updated Prices | Expedia.co.uk

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## Check prices for these dates

Tonight

[6 Mar - 7 Mar](https://www.expedia.co.uk/Hotel-Search?regionId=553248635978913844&startDate=2026-03-06&endDate=2026-03-07&adults=2&rfrr=TG.LP.CheckPrices.Hotel&openPlayBack=true)

Tomorrow

[7 Mar - 8 Mar](https://www.expedia.co.uk/Hotel-Search?regionId=553248635978913844&startDate=2026-03-07&endDate=2026-03-08&adults=2&rfrr=TG.LP.CheckPrices.Hotel&openPlayBack=true)

This weekend

[6 Mar - 8 Mar](https://www.expedia.co.uk/Hotel-Search?regionId=553248635978913844&startDate=2026-03-06&endDate=2026-03-08&adults=2&rfrr=TG.LP.CheckPrices.Hotel&openPlayBack=true)

Next weekend

[13 Mar - 15 Mar](https://www.expedia.co.uk/Hotel-Search?regionId=553248635978913844&startDate=2026-03-13&endDate=2026-03-15&adults=2&rfrr=TG.LP.CheckPrices.Hotel&openPlayBack=true)

Recommended

Price (low to high)

Distance

Property class

## Our top choices for Medical Center District hotels

![Lobby](https://images.trvl-media.com/lodging/1000000/10000/4200/4192/aa83e7de.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium)

![View from property](https://images.trvl-media.com/lodging/1000000/10000/4200/4192/243881ea.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium)

![Premium bedding, down duvets, pillow-top beds, in-room safe](https://images.trvl-media.com/lodging/1000000/10000/4200/4192/e0b99e2f.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium)

![Breakfast and dinner served, American cuisine](https://images.trvl-media.com/lodging/1000000/10000/4200/4192/053f15e4.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium)

### San Antonio Marriott Northwest Medical Center

[](https://www.expedia.co.uk/San-Antonio-Hotels-San-Antonio-Marriott-Northwest.h4192.Hotel-Information)

Medical Center District

8.6/10

Excellent

(1,006 reviews)

"Courteous staff, clean room, safe location "

![United States](https://a.travel-assets.com/egds/marks/flags/us.svg)

Danica

£76

includes taxes & fees

3 Apr - 4 Apr

[](https://www.expedia.co.uk/San-Antonio-Hotels-San-Antonio-Marriott-Northwest.h4192.Hotel-Information)

![Lobby](https://images.trvl-media.com/lodging/69000000/68850000/68847400/68847371/1c416f1a.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium)

![Premium bedding, desk, laptop workspace, free cots/infant beds](https://images.trvl-media.com/lodging/69000000/68850000/68847400/68847371/0716970b.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium)

![Reception](https://images.trvl-media.com/lodging/69000000/68850000/68847400/68847371/52bae0c9.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium)

![Exterior](https://images.trvl-media.com/lodging/69000000/68850000/68847400/68847371/fdfc11cc.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium)

### Fairfield Inn & Suites by Marriott San Antonio Medical Center

[](https://www.expedia.co.uk/San-Antonio-Hotels-Fairfield-Inn-Suites-By-Marriott-San-Antonio-Medical-Center.h68847371.Hotel-Information)

Medical Center District

9.0/10

Wonderful

(1,010 reviews)

"Very comfortable, everything was clean, great staff and it’s near all the important hospitals. "

![United States](https://a.travel-assets.com/egds/marks/flags/us.svg)

Jesus

£77

includes taxes & fees

1 Apr - 2 Apr

[](https://www.expedia.co.uk/San-Antonio-Hotels-Fairfield-Inn-Suites-By-Marriott-San-Antonio-Medical-Center.h68847371.Hotel-Information)

![Free daily buffet breakfast ](https://images.trvl-media.com/lodging/2000000/1620000/1614000/1613977/3b4d6808.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium)

![Courtyard](https://images.trvl-media.com/lodging/2000000/1620000/1614000/1613977/8fcc83d8.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium)

![Front of property](https://images.trvl-media.com/lodging/2000000/1620000/1614000/1613977/w9000h6173x0y15-23603cae.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium)

![Outdoor pool](https://images.trvl-media.com/lodging/2000000/1620000/1614000/1613977/667d95b8.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium)

### La Quinta Inn & Suites by Wyndham San Antonio Medical Ctr NW

[](https://www.expedia.co.uk/San-Antonio-Hotels-La-Quinta-Inn-Suites-By-Wyndham-San-Antonio-Medical-Ctr-NW.h1613977.Hotel-Information)

Medical Center District

8.4/10

Very good

(3,220 reviews)

"Great stay with nice breakfast and clean rooms "

![United States](https://a.travel-assets.com/egds/marks/flags/us.svg)

Leah

£78

includes taxes & fees

8 Mar - 9 Mar

[](https://www.expedia.co.uk/San-Antonio-Hotels-La-Quinta-Inn-Suites-By-Wyndham-San-Antonio-Medical-Ctr-NW.h1613977.Hotel-Information)

![Property entrance](https://images.trvl-media.com/lodging/1000000/700000/692600/692534/41551429.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium)

![Reception](https://images.trvl-media.com/lodging/1000000/700000/692600/692534/a061f3de.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium)

![Room, 2 Queen Beds | Television](https://images.trvl-media.com/lodging/1000000/700000/692600/692534/06f7cfb8.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium)

![Lobby sitting area](https://images.trvl-media.com/lodging/1000000/700000/692600/692534/e974d0cc.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium)

### OYO Inn & Suites Medical Center San Antonio

[](https://www.expedia.co.uk/San-Antonio-Hotels-OYO-Inn-Suites-Medical-Center-San-Antonio.h692534.Hotel-Information)

Medical Center District

7.2/10

Good

(229 reviews)

"Staff was courteous and professional and the room is nice."

![United States](https://a.travel-assets.com/egds/marks/flags/us.svg)

Thomas

£61

includes taxes & fees

8 Mar - 9 Mar

[](https://www.expedia.co.uk/San-Antonio-Hotels-OYO-Inn-Suites-Medical-Center-San-Antonio.h692534.Hotel-Information)

![Lobby](https://images.trvl-media.com/lodging/1000000/60000/59300/59226/86df295b.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium)

![Desk, blackout curtains, iron/ironing board, free cots/infant beds](https://images.trvl-media.com/lodging/1000000/60000/59300/59226/0e1dc134.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium)

![Lobby](https://images.trvl-media.com/lodging/1000000/60000/59300/59226/e4545fb5.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium)

![Indoor pool](https://images.trvl-media.com/lodging/1000000/60000/59300/59226/8e301658.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium)

### Drury Inn & Suites San Antonio Northwest Medical Center

[](https://www.expedia.co.uk/San-Antonio-Hotels-Drury-Inn-Suites-San-Antonio-Northwest-Medical-Center.h59226.Hotel-Information)

Medical Center District

9.2/10

Wonderful

(1,281 reviews)

"Excellent awesome place we love it Room was super clean staff super nice "

![United States](https://a.travel-assets.com/egds/marks/flags/us.svg)

Maria

£79

includes taxes & fees

30 Mar - 31 Mar

[](https://www.expedia.co.uk/San-Antonio-Hotels-Drury-Inn-Suites-San-Antonio-Northwest-Medical-Center.h59226.Hotel-Information)

![Bar (on property)](https://images.trvl-media.com/lodging/1000000/20000/12600/12556/1e7b2c4d.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium)

![Exterior](https://images.trvl-media.com/lodging/1000000/20000/12600/12556/2045bf85.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium)

![In-room safe, desk, iron/ironing board, free cots/infant beds](https://images.trvl-media.com/lodging/1000000/20000/12600/12556/db09d138.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium)

![Flat-screen TV, pay films](https://images.trvl-media.com/lodging/1000000/20000/12600/12556/f47c7eb6.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium)

### Courtyard by Marriott Medical Center San Antonio

[](https://www.expedia.co.uk/San-Antonio-Hotels-Courtyard-By-Marriott-Medical-Center-San-Antonio.h12556.Hotel-Information)

Medical Center District

8.8/10

Excellent

(1,004 reviews)

"Clean rooms @ friendly staff!"

![United States](https://a.travel-assets.com/egds/marks/flags/us.svg)

LaTishe

£78

includes taxes & fees

30 Mar - 31 Mar

[](https://www.expedia.co.uk/San-Antonio-Hotels-Courtyard-By-Marriott-Medical-Center-San-Antonio.h12556.Hotel-Information)

![Breakfast area](https://images.trvl-media.com/lodging/1000000/30000/28200/28102/9628dbca.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium)

![Exterior](https://images.trvl-media.com/lodging/1000000/30000/28200/28102/ea511f30.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium)

![Lobby](https://images.trvl-media.com/lodging/1000000/30000/28200/28102/fea7afce.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium)

![Free WiFi, bed sheets](https://images.trvl-media.com/lodging/1000000/30000/28200/28102/4918a4df.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium)

### Park Inn by Radisson

[](https://www.expedia.co.uk/San-Antonio-Hotels-Welcome-Inn-San-Antonio-Medical-Center.h28102.Hotel-Information)

Medical Center District

7.2/10

Good

(1,003 reviews)

"Room was spotless and bed was great."

![United States](https://a.travel-assets.com/egds/marks/flags/us.svg)

Pamela

£55

includes taxes & fees

26 Mar - 27 Mar

[](https://www.expedia.co.uk/San-Antonio-Hotels-Welcome-Inn-San-Antonio-Medical-Center.h28102.Hotel-Information)

![Desk, laptop workspace, blackout curtains, free WiFi](https://images.trvl-media.com/lodging/84000000/83410000/83406000/83405963/cfce1826.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium)

![Laundry room](https://images.trvl-media.com/lodging/84000000/83410000/83406000/83405963/0d622081.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium)

![Lobby](https://images.trvl-media.com/lodging/84000000/83410000/83406000/83405963/15001725.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium)

![Full-sized fridge, microwave, coffee/tea maker, cookware/dishes/utensils](https://images.trvl-media.com/lodging/84000000/83410000/83406000/83405963/e2843e2f.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium)

### Studio 6 San Antonio, Tx - Northwest Medical Center

[](https://www.expedia.co.uk/San-Antonio-Hotels-Studio-6-San-Antonio.h83405963.Hotel-Information)

Medical Center District

7.4/10

Good

(253 reviews)

"Good stay and safe area"

![United States](https://a.travel-assets.com/egds/marks/flags/us.svg)

Mario

£41

includes taxes & fees

8 Mar - 9 Mar

[](https://www.expedia.co.uk/San-Antonio-Hotels-Studio-6-San-Antonio.h83405963.Hotel-Information)

![Basic Room, 1 King Bed, Non Smoking | Desk, iron/ironing board, free WiFi, bed sheets](https://images.trvl-media.com/lodging/76000000/75220000/75211700/75211602/53fea236.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium)

![Exterior](https://images.trvl-media.com/lodging/76000000/75220000/75211700/75211602/00bf65b4.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium)

![Exterior](https://images.trvl-media.com/lodging/76000000/75220000/75211700/75211602/52d716c1.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium)

![Free toiletries, towels, soap, shampoo](https://images.trvl-media.com/lodging/76000000/75220000/75211700/75211602/1b080b9d.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium)

### Flex Studios

[](https://www.expedia.co.uk/San-Antonio-Hotels-Flex-Studios.h75211602.Hotel-Information)

Medical Center District

6.0/10

(511 reviews)

"Was good, but there is no one overnight, security doesn't answer and the opening person was almost an hour late. "

![United States](https://a.travel-assets.com/egds/marks/flags/us.svg)

Michelle

£35

includes taxes & fees

15 Mar - 16 Mar

[](https://www.expedia.co.uk/San-Antonio-Hotels-Flex-Studios.h75211602.Hotel-Information)

![Front of property](https://images.trvl-media.com/lodging/97000000/96190000/96182100/96182039/1b117ba4.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium)

![1 King Deluxe Suite | Desk, iron/ironing board, free WiFi, bed sheets](https://images.trvl-media.com/lodging/97000000/96190000/96182100/96182039/3d551d47.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium)

![1 King Deluxe Suite | Desk, iron/ironing board, free WiFi, bed sheets](https://images.trvl-media.com/lodging/97000000/96190000/96182100/96182039/76d52754.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium)

![Front of property](https://images.trvl-media.com/lodging/97000000/96190000/96182100/96182039/82bbe653.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium)

### Atria Inn & Suites

[](https://www.expedia.co.uk/San-Antonio-Hotels-9727-Fredericksburg-Rd.h96182039.Hotel-Information)

Medical Center District

7.6/10

Good

(284 reviews)

"Room was good standings, staff was friendly "

![United States](https://a.travel-assets.com/egds/marks/flags/us.svg)

Luis

[](https://www.expedia.co.uk/San-Antonio-Hotels-9727-Fredericksburg-Rd.h96182039.Hotel-Information)

![Desk, laptop workspace, free WiFi, bed sheets](https://images.trvl-media.com/lodging/1000000/60000/51000/50914/c7a8846b.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium)

![Vending machine](https://images.trvl-media.com/lodging/1000000/60000/51000/50914/45eebc93.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium)

![Fridge, microwave, coffee/tea maker, dining tables](https://images.trvl-media.com/lodging/1000000/60000/51000/50914/4c605dff.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium)

![Desk, laptop workspace, free WiFi, bed sheets](https://images.trvl-media.com/lodging/1000000/60000/51000/50914/10b53b97.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium)

### Studio 6 San Antonio, TX - Medical Center

[](https://www.expedia.co.uk/San-Antonio-Hotels-Studio-6-San-Antonio.h50914.Hotel-Information)

Medical Center District

6.8/10

(834 reviews)

"Staff was great, very clean rooom"

![United States](https://a.travel-assets.com/egds/marks/flags/us.svg)

Laura

£43

includes taxes & fees

8 Mar - 9 Mar

[](https://www.expedia.co.uk/San-Antonio-Hotels-Studio-6-San-Antonio.h50914.Hotel-Information)

![Free WiFi, bed sheets](https://images.trvl-media.com/lodging/1000000/60000/50600/50555/c1974da9.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium)

![Exterior](https://images.trvl-media.com/lodging/1000000/60000/50600/50555/a8e3513c.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium)

![Lobby](https://images.trvl-media.com/lodging/1000000/60000/50600/50555/a69289e3.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium)

![Outdoor pool](https://images.trvl-media.com/lodging/1000000/60000/50600/50555/ff104fca.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium)

### Motel 6 San Antonio, TX - Northwest Medical Center

[](https://www.expedia.co.uk/San-Antonio-Hotels-Motel-6-San-Antonio.h50555.Hotel-Information)

Medical Center District

6.0/10

(1,000 reviews)

"Room was clean, beds comfortable, staff extremely friendly and helpful "

![United States](https://a.travel-assets.com/egds/marks/flags/us.svg)

Kathleen

£42

includes taxes & fees

8 Mar - 9 Mar

[](https://www.expedia.co.uk/San-Antonio-Hotels-Motel-6-San-Antonio.h50555.Hotel-Information)

![Free daily on-the-go breakfast ](https://images.trvl-media.com/lodging/12000000/11750000/11744300/11744297/63a40a4f.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium)

![Lobby](https://images.trvl-media.com/lodging/12000000/11750000/11744300/11744297/ca8040db.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium)

![Fitness facility](https://images.trvl-media.com/lodging/12000000/11750000/11744300/11744297/5f7054f8.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium)

![Property amenity](https://images.trvl-media.com/lodging/12000000/11750000/11744300/11744297/e79204bf.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium)

### Country Inn & Suites by Radisson, San Antonio Medical Center, TX

[](https://www.expedia.co.uk/San-Antonio-Hotels-Country-Inn-Suites-By-Radisson.h11744297.Hotel-Information)

Medical Center District

6.8/10

(1,007 reviews)

"Great place , front desk are helpful and friendly. Safe place to stay ."

![United States](https://a.travel-assets.com/egds/marks/flags/us.svg)

Justin

£51

includes taxes & fees

29 Mar - 30 Mar

[](https://www.expedia.co.uk/San-Antonio-Hotels-Country-Inn-Suites-By-Radisson.h11744297.Hotel-Information)

![Exterior](https://images.trvl-media.com/lodging/1000000/20000/16200/16129/c4a6b786.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium)

![Reception](https://images.trvl-media.com/lodging/1000000/20000/16200/16129/78b57ad8.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium)

![Fitness facility](https://images.trvl-media.com/lodging/1000000/20000/16200/16129/ce079052.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium)

![Outdoor pool, open 9:00 AM to 11:00 PM, pool loungers](https://images.trvl-media.com/lodging/1000000/20000/16200/16129/5f6bebbc.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium)

### Best Western Garden Inn

[](https://www.expedia.co.uk/San-Antonio-Hotels-Best-Western-Garden-Inn.h16129.Hotel-Information)

Uptown, 13.2 mi from Medical Center District

8.2/10

Very good

(1,005 reviews)

"Clean room, friendly and helpful staff."

![United States](https://a.travel-assets.com/egds/marks/flags/us.svg)

Robyn

£56

includes taxes & fees

8 Mar - 9 Mar

[](https://www.expedia.co.uk/San-Antonio-Hotels-Best-Western-Garden-Inn.h16129.Hotel-Information)

![Fireplace](https://images.trvl-media.com/lodging/2000000/1120000/1113200/1113168/4657a7fb.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium)

![Front of property](https://images.trvl-media.com/lodging/2000000/1120000/1113200/1113168/72554b53.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium)

![Lobby](https://images.trvl-media.com/lodging/2000000/1120000/1113200/1113168/4f4dbae3.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium)

![Waterslide](https://images.trvl-media.com/lodging/2000000/1120000/1113200/1113168/f77355b3.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium)

### Hyatt Vacation Club at Wild Oak Ranch, San Antonio

[](https://www.expedia.co.uk/San-Antonio-Hotels-Hyatt-Vacation-Club-At-Wild-Oak-Ranch.h1113168.Hotel-Information)

Far West Side, 7 mi from Medical Center District

9.0/10

Wonderful

(1,498 reviews)

"Great Stay"

![United States](https://a.travel-assets.com/egds/marks/flags/us.svg)

Melissa

£97

includes taxes & fees

22 Mar - 23 Mar

[](https://www.expedia.co.uk/San-Antonio-Hotels-Hyatt-Vacation-Club-At-Wild-Oak-Ranch.h1113168.Hotel-Information)

![Room amenity](https://images.trvl-media.com/lodging/88000000/87820000/87818100/87818058/6c1b3082.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium)

![Property amenity](https://images.trvl-media.com/lodging/88000000/87820000/87818100/87818058/82fd706d.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium)

![Exterior](https://images.trvl-media.com/lodging/88000000/87820000/87818100/87818058/6e566597.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium)

![Lobby](https://images.trvl-media.com/lodging/88000000/87820000/87818100/87818058/34ebc80f.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium)

### Staybridge Suites San Antonio Lackland AFB Area by IHG

[](https://www.expedia.co.uk/San-Antonio-Hotels-Staybridge-Suites-San-Antonio-Richland-Hills.h87818058.Hotel-Information)

Far West Side, 6 mi from Medical Center District

9.6/10

Exceptional

(422 reviews)

"Breakfast, evening social, kitchenettes, friendly staff, good location to visit downtown and Lackland Airforce base."

![United States](https://a.travel-assets.com/egds/marks/flags/us.svg)

Kelly

£84

includes taxes & fees

29 Mar - 30 Mar

[](https://www.expedia.co.uk/San-Antonio-Hotels-Staybridge-Suites-San-Antonio-Richland-Hills.h87818058.Hotel-Information)

![Outdoor pool, open 9:00 AM to 10:00 PM, pool cabanas (surcharge)](https://images.trvl-media.com/lodging/1000000/30000/27900/27848/f40a8bb2.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium)

![Poolside views, open daily](https://images.trvl-media.com/lodging/1000000/30000/27900/27848/9b05a270.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium)

![Meeting facility](https://images.trvl-media.com/lodging/1000000/30000/27900/27848/d2818479.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium)

![Poolside views, open daily](https://images.trvl-media.com/lodging/1000000/30000/27900/27848/74fd26e3.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium)

### Plaza San Antonio Hotel & Spa, Autograph Collection

[](https://www.expedia.co.uk/San-Antonio-Hotels-The-Otis-Hotel-San-Antonio.h27848.Hotel-Information)

Downtown San Antonio, 8 mi from Medical Center District

9.4/10

Exceptional

(735 reviews)

"The room was great and staff was very helpful and kind. "

![United States](https://a.travel-assets.com/egds/marks/flags/us.svg)

Corina

£172

includes taxes & fees

5 Apr - 6 Apr

[](https://www.expedia.co.uk/San-Antonio-Hotels-The-Otis-Hotel-San-Antonio.h27848.Hotel-Information)

![Standard Studio, 1 King Bed, Refrigerator & Microwave | Premium bedding, laptop workspace, iron/ironing board, free WiFi](https://images.trvl-media.com/lodging/111000000/110170000/110167700/110167699/c658d6d2.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium)

![Fitness facility](https://images.trvl-media.com/lodging/111000000/110170000/110167700/110167699/dffc90af.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium)

![Free daily on-the-go breakfast ](https://images.trvl-media.com/lodging/111000000/110170000/110167700/110167699/3c09f5e7.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium)

![Exterior](https://images.trvl-media.com/lodging/111000000/110170000/110167700/110167699/9293cc9d.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium)

### Extended Stay America Premier Suites - San Antonio - Schertz

[](https://www.expedia.co.uk/San-Antonio-Hotels-Extended-Stay-America-Premier-Suites-San-Antonio-Schertz.h110167699.Hotel-Information)

18.2 mi from Medical Center District

9.2/10

Wonderful

(214 reviews)

"Room was excellent and staff were friendly and helpful. Will stay here again"

![United States](https://a.travel-assets.com/egds/marks/flags/us.svg)

Sharon

£73

includes taxes & fees

22 Mar - 23 Mar

[](https://www.expedia.co.uk/San-Antonio-Hotels-Extended-Stay-America-Premier-Suites-San-Antonio-Schertz.h110167699.Hotel-Information)

![Restaurant](https://images.trvl-media.com/lodging/50000000/49150000/49148700/49148640/4db1357c.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium)

![Restaurant](https://images.trvl-media.com/lodging/50000000/49150000/49148700/49148640/9bb2dd09.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium)

![Reception](https://images.trvl-media.com/lodging/50000000/49150000/49148700/49148640/3ded3c64.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium)

![Bar (on property)](https://images.trvl-media.com/lodging/50000000/49150000/49148700/49148640/15176e54.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium)

### Canopy by Hilton San Antonio Riverwalk

[](https://www.expedia.co.uk/San-Antonio-Hotels-Canopy-By-Hilton-San-Antonio-Riverwalk.h49148640.Hotel-Information)

Downtown San Antonio, 7.6 mi from Medical Center District

9.4/10

Exceptional

(1,632 reviews)

"Great hospitality and location. "

![United States](https://a.travel-assets.com/egds/marks/flags/us.svg)

Shannon

£153

includes taxes & fees

1 Apr - 2 Apr

[](https://www.expedia.co.uk/San-Antonio-Hotels-Canopy-By-Hilton-San-Antonio-Riverwalk.h49148640.Hotel-Information)

![Lobby](https://images.trvl-media.com/lodging/17000000/16220000/16219100/16219094/df4bd134.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium)

![Free daily full breakfast ](https://images.trvl-media.com/lodging/17000000/16220000/16219100/16219094/826c8b04.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium)

![Exterior](https://images.trvl-media.com/lodging/17000000/16220000/16219100/16219094/5e9a8e3e.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium)

![Suite, 2 Queen Beds, Non Smoking, Refrigerator & Microwave | Pillow-top beds, desk, laptop workspace, iron/ironing board](https://images.trvl-media.com/lodging/17000000/16220000/16219100/16219094/385e631c.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium)

### Best Western Plus Downtown North

[](https://www.expedia.co.uk/San-Antonio-Hotels-Best-Western-Plus-Downtown-North.h16219094.Hotel-Information)

8.3 mi from Medical Center District

8.6/10

Excellent

(1,008 reviews)

"Great stay. Everything was pretty much close riverwalk etc. clean rooms and courteous staff. Breakfast was good too. "

![United States](https://a.travel-assets.com/egds/marks/flags/us.svg)

Miguel Garrido

£77

includes taxes & fees

8 Mar - 9 Mar

[](https://www.expedia.co.uk/San-Antonio-Hotels-Best-Western-Plus-Downtown-North.h16219094.Hotel-Information)

Lowest nightly price found within the past 24 hours based on a 1 night stay for 2 adults. Prices and availability subject to change. Additional terms may apply.

[View all properties](https://expedia.co.uk/Hotel-Search?startDate=2026-03-21&endDate=2026-03-22&regionId=553248635978913844&adults=2&sort=RECOMMENDED&openPlayBack=true)

## Where to stay in Medical Center District

Find the best Medical Center District areas for the activities you enjoy most. 

- Downtown San Antonio
- Uptown
- Far West Side
- Stone Oak
- Arena District

![Downtown - Riverwalk showing a river or creek, a bridge and boating](https://images.trvl-media.com/place/800120/c427a760-8f08-4152-8ff2-5ee8720d9068.jpg?impolicy=fcrop&w=960&h=540&p=1&q=medium)

![Downtown San Antonio which includes cafe lifestyle, night scenes and boating](https://images.trvl-media.com/place/800120/4b544474-7c50-4664-b4ab-ad70250a41a0.jpg?impolicy=fcrop&w=960&h=540&p=1&q=medium)

![Downtown - Riverwalk which includes signage](https://images.trvl-media.com/place/800120/135587e2-2707-47b4-9d5d-cb8857baf764.jpg?impolicy=fcrop&w=960&h=540&p=1&q=medium)

![Downtown - Riverwalk which includes street scenes, outdoor eating and a city](https://images.trvl-media.com/place/800120/d5fb17cd-5ebd-4eba-ae25-0c264111a700.jpg?impolicy=fcrop&w=960&h=540&p=1&q=medium)

![Downtown - Riverwalk featuring boating and a river or creek](https://images.trvl-media.com/place/800120/4342dae3-9acc-4423-bc98-26f47e6b055f.jpg?impolicy=fcrop&w=960&h=540&p=1&q=medium)

[](https://www.expedia.co.uk/Hotel-Search?pwaOverlay=map&regionId=800120)

![Downtown San Antonio map](https://maps.googleapis.com/maps/api/staticmap?&size=289x340&map_id=c017d89749dc74ad&markers=icon:%7C&path=enc:%7BrmrDhqgxQ%7Bu%40iUe%60%40ia%40y%7EAmMkRgUqO_d%40wPi%5CT%7DPdJmc%40xQElH%60CrZlR%7EIgDjNP%3FuPbh%40Lph%40a%40pQtLzb%40bFvIXdg%40mPxE%60R%7BK%60%7CAaAd%7EAoc%40dA&key=AIzaSyAoVHdVOa5-BDRxGhFoAHYIHPst1T09Jo0&signature=RuyIpZHEnQcp_rXJYAlWPqPpku0=)

### Downtown San Antonio

Explore the network of pedestrian paths that follows the beautiful San Antonio River to discover restaurants and bars, gift shops, galleries and museums.

[See properties](https://www.expedia.co.uk/Hotel-Search?regionId=800120)

![It's Texas, of course everything is bigger! #guinessworldrecord #visittexas #hdr #fisheye](https://images.trvl-media.com/place/3077/4cdbcd9a-ec5a-47a7-8436-9b378ab6bf93.jpg?impolicy=fcrop&w=960&h=540&p=1&q=medium)

Photo by Sarah C. 

![Marion Koogler McNay Art Museum which includes art and interior views as well as an individual male](https://images.trvl-media.com/place/502610/f2b1df08-6a69-4feb-8248-be1130a68fb3.jpg?impolicy=fcrop&w=960&h=540&p=1&q=medium)

![SanAntonio_NorthStarMall_502628_05](https://images.trvl-media.com/place/502628/fc86b101-dc2f-4e75-a1bf-b214a3fa4dc2.jpg?impolicy=fcrop&w=960&h=540&p=1&q=medium)

[](https://www.expedia.co.uk/Hotel-Search?pwaOverlay=map&regionId=553248635974902947)

![Uptown map](https://maps.googleapis.com/maps/api/staticmap?&size=289x340&map_id=c017d89749dc74ad&markers=icon:%7C&path=enc:ydesDviexQgd%40qGeaDglA%7BiAuZssAq%5Cof%40aLcgCoh%40wHeEx%5C_fB%60YwpB%7BMooG%7B%40%7D_DlF%7BZhHuIbgCm%7DAdJvIjUpGzM%7EMhHha%40nFrG%60YePfWmEbYcPlF%3FhHxKdJvg%40%7CZ%7Cx%40%7Cv%40p_BzKhXfLrPlb%40xXzi%40tIn%60%40dn%40rDhRz%40%7C%7DDlFfAfW%7BK%7EpA%3FxOuVjUnEzMqGjU%3FdoAzi%40hHtIpDvXhH%7EMz%40dhB%7CM%7EMz%40ha%40%3Fj_AmF%60Nx%40bhBqDlEs%7BIbA&key=AIzaSyAoVHdVOa5-BDRxGhFoAHYIHPst1T09Jo0&signature=j0bUoKNjCSIIV8aMqbcD3ISkFXM=)

### Uptown

If you're spending some time in Uptown, San Antonio Zoo and Aquarium and Marion Koogler McNay Art Museum are top sights worth seeing. 

[See properties](https://www.expedia.co.uk/Hotel-Search?regionId=553248635974902947)

![SanAntonio_SanAntonioSeaWorld_502636_04](https://images.trvl-media.com/place/502636/21ddbcf6-e0f6-4e89-a158-96c7800472ba.jpg?impolicy=fcrop&w=960&h=540&p=1&q=medium)

![SeaWorld San Antonio is one of the world's largest marine life parks and spans 416 acres. SeaWorldoffers an exciting and educational blend of extraordinary marine-life shows, rides, and attractions, as well as up-close animal encounters and behind-the-scenes tours.

](https://images.trvl-media.com/place/3077/08b2cbda-5618-42d5-95f6-c67aaf059c26.jpg?impolicy=fcrop&w=960&h=540&p=1&q=medium)

Photo by Dean Moore

![](https://images.trvl-media.com/place/3077/f575c4b1-bcb1-4812-8208-54a3a54b6ebf.jpg?impolicy=fcrop&w=960&h=540&p=1&q=medium)

![](https://images.trvl-media.com/place/3077/55bed7d9-3745-4494-865f-1356c1ad509c.jpg?impolicy=fcrop&w=960&h=540&p=1&q=medium)

![](https://images.trvl-media.com/place/3077/648ee6fc-247e-4471-88bf-89e6ed95d234.jpg?impolicy=fcrop&w=960&h=540&p=1&q=medium)

[](https://www.expedia.co.uk/Hotel-Search?pwaOverlay=map&regionId=553248635975749416)

![Far West Side map](https://maps.googleapis.com/maps/api/staticmap?&size=289x340&map_id=c017d89749dc74ad&markers=icon:%7C&path=enc:afyrDb%7EwyQkpLsbDyqCo%7B%40d%7BAi%7EDbJih%40ukAsa%40mp%40yr%40raBofBxZaj%40xfAeu%40bn%40uRtf%40y%5DpqAwr%40%7ChAg%60B%7CKqLlOyd%40xKhZp%7DAbzArdEheDrUxOfQpDjzDl%40%60XfbAn%5DblAph%40bnD%7EX%7EgBjPviDmpJzf%40gkDbr%40&key=AIzaSyAoVHdVOa5-BDRxGhFoAHYIHPst1T09Jo0&signature=VMxJSqyr4lT0QcBLFKtAFNJkV0g=)

### Far West Side

While visiting Far West Side, you might make a stop by sights like Aquatica San Antonio Waterpark and Hill Country Golf Club. 

[See properties](https://www.expedia.co.uk/Hotel-Search?regionId=553248635975749416)

![Famous American landmark - Alamo mission in downtown San Antonio, Texas, USA](https://images.trvl-media.com/place/6343068/f511f264-1622-41ec-949e-c6074dc12bcb.jpg?impolicy=fcrop&w=960&h=540&p=1&q=medium)

![SanAntonio_StoneOak_6343068_01](https://images.trvl-media.com/place/6343068/7278ad15-e098-4e46-b18d-52e713033ba5.jpg?impolicy=fcrop&w=960&h=540&p=1&q=medium)

[](https://www.expedia.co.uk/Hotel-Search?pwaOverlay=map&regionId=6343068)

![Stone Oak map](https://maps.googleapis.com/maps/api/staticmap?&size=289x340&map_id=c017d89749dc74ad&markers=icon:%7C&path=enc:qg_tDfmixQqXq_Mx%60I%7EuBmHzl%40vObfEmiB%60eAcdEnM&key=AIzaSyAoVHdVOa5-BDRxGhFoAHYIHPst1T09Jo0&signature=S1oBhJpmo5OYXFc5vi-iyXqubu4=)

### Stone Oak

Stone Oak is known for its abundant dining options, and you can plan a trip to Shops at Hardy Oak and Alta Vista while you're in town. 

[See properties](https://www.expedia.co.uk/Hotel-Search?regionId=6343068)

![The Alamo, San Antonio, USA © Arena Photo UK](https://images.trvl-media.com/place/553248635976384171/5c700a4e-c87b-4025-8a9d-148e2d7ae617.jpg?impolicy=fcrop&w=960&h=540&p=1&q=medium)

![SanAntonio_FreemanColiseum_502631_04](https://images.trvl-media.com/place/502631/69fc7a4e-59cf-4406-a292-faad74e0526a.jpg?impolicy=fcrop&w=960&h=540&p=1&q=medium)

![The San Antonio Spurs](https://images.trvl-media.com/place/3077/65ec6a9c-1221-429d-8b58-b82ce63c93ac.jpg?impolicy=fcrop&w=960&h=540&p=1&q=medium)

Photo by George Zimzores

![Street art in San Antonio](https://images.trvl-media.com/place/3077/acd4e1c9-a686-4032-9510-f2238e3391a2.jpg?impolicy=fcrop&w=960&h=540&p=1&q=medium)

Photo by Sara Crotts

![Street art in San Antonio](https://images.trvl-media.com/place/3077/8ebae03a-8d34-471f-9235-727bb2daca12.jpg?impolicy=fcrop&w=960&h=540&p=1&q=medium)

Photo by Sara Crotts

[](https://www.expedia.co.uk/Hotel-Search?pwaOverlay=map&regionId=553248635976384171)

![Arena District map](https://maps.googleapis.com/maps/api/staticmap?&size=289x340&map_id=c017d89749dc74ad&markers=icon:%7C&path=enc:ksmrDtqaxQ%7Bl%40gH_N%7CBoKFxIeQrKeOuIEHci%40cn%40%3F%3FaXcZf%40AyCeGJ%3FgLeFAUi%40um%40ASzhB_CiAeKuAL%7BfBxB_k%40r%40c%40rBui%40HqIq%40qM_Ps%40%7DPeB%7D%7C%40cg%40%7DIuNoNoL%7DHcQPgqA%7CIwDjDyOdLuTtUuXtNi%5D%7CLcRrScSjKaGpMeE%60mAmCkCrRWlrAoCne%40Rvx%40%7CGtGhe%40b%5BxiAttAxHzKdCjGmGjLpG%7EJvG%3FIriB%60%40hZ%60GjOpKpM%60I%7CF%7EIhLwd%40%7EOmHv%40&key=AIzaSyAoVHdVOa5-BDRxGhFoAHYIHPst1T09Jo0&signature=6hrpI9VtJejTYy1e3i9k2g_nnRA=)

### Arena District

If you're spending some time in Arena District, Frost Bank Center and Freeman Coliseum are top sights worth seeing. 

[See properties](https://www.expedia.co.uk/Hotel-Search?regionId=553248635976384171)

## Top Medical Center District Hotel Reviews

![Riverwalk Plaza](https://images.trvl-media.com/lodging/1000000/290000/288400/288321/ef3ca433_y.jpg)

### Riverwalk Plaza

2/10 Terrible

"Room needs major updates along with all rust removed from bathtubs "

[](https://expedia.co.uk/San-Antonio-Hotels-Riverwalk-Plaza.h288321.Hotel-Information)

![Kimpton Santo San Antonio - Riverwalk by IHG](https://images.trvl-media.com/lodging/105000000/104350000/104343200/104343109/e0a928b3_y.jpg)

### Kimpton Santo San Antonio - Riverwalk by IHG

10/10 Excellent

"The only problem I encountered was a room located next to the elevator. "

[](https://expedia.co.uk/San-Antonio-Hotels-Kimpton-Santo.h104343109.Hotel-Information)

![Menger Hotel](https://images.trvl-media.com/lodging/1000000/10000/5900/5877/ae1a8ff6_y.jpg)

### Menger Hotel

8/10 Good

"Super location and great rates. Rooms are old fashioned and bathrooms are tiny . Close to the Alamo and walking distance to the River walk. "

[](https://expedia.co.uk/San-Antonio-Hotels-Menger-Hotel.h5877.Hotel-Information)

![Hotel Valencia Riverwalk](https://images.trvl-media.com/lodging/1000000/900000/897400/897388/c044e985_y.jpg)

### Hotel Valencia Riverwalk

10/10 Excellent

"We were there for business and it was a great location and nice property"

[](https://expedia.co.uk/San-Antonio-Hotels-Hotel-Valencia-Riverwalk.h897388.Hotel-Information)

![Hyatt Vacation Club at Wild Oak Ranch, San Antonio](https://images.trvl-media.com/lodging/2000000/1120000/1113200/1113168/4657a7fb_y.jpg)

### Hyatt Vacation Club at Wild Oak Ranch, San Antonio

10/10 Excellent

"We really enjoyed our stay at the Oak Ranch The place was clean and the amenities were great!"

[](https://expedia.co.uk/San-Antonio-Hotels-Hyatt-Vacation-Club-At-Wild-Oak-Ranch.h1113168.Hotel-Information)

![Holiday Inn San Antonio - Riverwalk by IHG](https://images.trvl-media.com/lodging/1000000/20000/12700/12642/5f5ef28b_y.jpg)

### Holiday Inn San Antonio - Riverwalk by IHG

10/10 Excellent

"Great stay! We enjoyed the surroundings and everything about our stay. "

[](https://expedia.co.uk/San-Antonio-Hotels-Holiday-Inn-San-Antonio-Riverwalk.h12642.Hotel-Information)

![Wyndham Garden San Antonio Airport](https://images.trvl-media.com/lodging/1000000/20000/15800/15751/51291603_y.jpg)

### Wyndham Garden San Antonio Airport

10/10 Excellent

"Very nice hotel and spacious suite. Breakfast was ok. Shuttle is convenient. Close to airport. Friendly staff."

[](https://expedia.co.uk/San-Antonio-Hotels-Drury-Inn-Suites-San-Antonio-Airport.h15751.Hotel-Information)

![La Quinta Inn & Suites by Wyndham San Antonio Medical Ctr NW](https://images.trvl-media.com/lodging/2000000/1620000/1614000/1613977/3b4d6808_y.jpg)

### La Quinta Inn & Suites by Wyndham San Antonio Medical Ctr NW

10/10 Excellent

"Clean room, friendly staff, nice environment."

[](https://expedia.co.uk/San-Antonio-Hotels-La-Quinta-Inn-Suites-By-Wyndham-San-Antonio-Medical-Ctr-NW.h1613977.Hotel-Information)

![Hyatt Regency San Antonio Riverwalk](https://images.trvl-media.com/lodging/1000000/20000/10700/10636/b322b66a_y.jpg)

### Hyatt Regency San Antonio Riverwalk

10/10 Excellent

"Really nice property! Very clean and friendly staff"

[](https://expedia.co.uk/San-Antonio-Hotels-Hyatt-Regency-San-Antonio-Riverwalk.h10636.Hotel-Information)

## Frequently asked questions

### What is Medical Center District like?

### What's a favourite hotel to stay in Medical Center District?

### How many hotels will I be able to find in Medical Center District?

### If I need to cancel my hotel reservation in Medical Center District, will I receive a refund?

### What can I see and do in this San Antonio neighbourhood?

## Explore a world of travel with Expedia

- More ways to book

- [Book Hotels in Medical Center District on Expedia.com ](https://www.expedia.com/Medical-Center-District-San-Antonio-Hotels.0-n553248635978913844-0.Travel-Guide-Filter-Hotels)