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Check prices for these dates

Tonight
14 Oct - 15 Oct
Tomorrow
15 Oct - 16 Oct
This weekend
16 Oct - 18 Oct
Next weekend
23 Oct - 25 Oct

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Our top choices for Saint Francis Medical Center hotels

A spacious lobby with a circular seating area, a stone fireplace, and modern lighting fixtures.
An indoor swimming pool with clear blue water, surrounded by beige walls and large windows.
A spacious corridor with a high ceiling, recessed lighting, and a series of posters on the walls.
A spacious lobby with a curved seating area, a reception desk, and a large window providing natural light.

1. Drury Plaza Hotel Cape Girardeau Conference Center

Drury Plaza Hotel Cape Girardeau Conference Center
0.5 mi from Saint Francis Medical Center
United States
Darnetta
£85
includes taxes & fees
1 Nov - 2 Nov
Drury Plaza Hotel Cape Girardeau Conference Center
A spacious dining area with high ceilings, large windows, and modern lighting fixtures.
A gym with exercise equipment, a treadmill, and a wall-mounted TV.
An outdoor patio with stone walls, wicker furniture, and large windows.
A large indoor swimming pool with clear blue water, surrounded by tiled flooring and blue walls.

2. Hampton Inn Cape Girardeau I 55 East

Hampton Inn Cape Girardeau I 55 East
0.3 mi from Saint Francis Medical Center
United States
Rebekah
£90
includes taxes & fees
25 Oct - 26 Oct
Hampton Inn Cape Girardeau I 55 East
A hotel room with a large bed, two bedside lamps, a chair, and a wooden headboard.
A breakfast setting with waffles, scrambled eggs, toast, a glass of orange juice, and a white mug on a table with a green placemat.
A plate of mixed greens salad with cherry tomatoes and croutons, a bowl of baked pasta, and a glass of red wine on a wooden table.
A bowl of cereal with raisins and milk, a half orange, and a sandwich on a table with a yellow napkin.

3. Drury Inn & Suites Cape Girardeau

Drury Inn & Suites Cape Girardeau
0.6 mi from Saint Francis Medical Center
United States
Teresa
£77
includes taxes & fees
25 Oct - 26 Oct
Drury Inn & Suites Cape Girardeau
A modern living room with a sofa, armchairs, a coffee table, and a TV mounted on the wall.
A modern living room with a sofa, a coffee table, and a dining area with chairs and a table.
A Fairfield by Marriott hotel with a modern design, featuring a stone facade, multiple floors, and a well-lit entrance.
An indoor swimming pool with lounge chairs and tables, large windows, and a view of the outside.

4. Fairfield Inn & Suites by Marriott Cape Girardeau

Fairfield Inn & Suites by Marriott Cape Girardeau
0.9 mi from Saint Francis Medical Center
United States
Carlos
£86
includes taxes & fees
25 Oct - 26 Oct
Fairfield Inn & Suites by Marriott Cape Girardeau
A spacious lobby with a fireplace, comfortable seating, a staircase, and a large chandelier.
A living room with a stone fireplace, a television mounted above it, and a large sofa with cushions.
An indoor swimming pool with a clear view of the pool area, including the pool's edge, a set of stairs leading into the pool, and a few lounge chairs and tables around the pool.
A hotel room with a bed, desk, chair, TV, and a small kitchenette area.

5. Holiday Inn Express Hotel & Suites Cape Girardeau I-55 by IHG

Holiday Inn Express Hotel & Suites Cape Girardeau I-55 by IHG
0.3 mi from Saint Francis Medical Center
United States
Rebecca
£87
includes taxes & fees
25 Oct - 26 Oct
Holiday Inn Express Hotel & Suites Cape Girardeau I-55 by IHG
A hotel room with a blue sofa, an orange ottoman, a desk with a lamp, a television, and a window with curtains.
A Dear Tree Inn building with a covered entrance and a clear sky at dusk.
A reception area with a wooden reception desk, two blue armchairs with orange cushions, a patterned side table, and a wall-mounted lamp.
A modern dining area with wooden tables and chairs, a kitchen area with a tiled backsplash, and framed pictures on the wall.

6. Pear Tree Inn Cape Girardeau West

Pear Tree Inn Cape Girardeau West
0.5 mi from Saint Francis Medical Center
United States
Troy
£61
includes taxes & fees
25 Oct - 26 Oct
Pear Tree Inn Cape Girardeau West
A hotel with a modern design, featuring a prominent sign for Candlewood Suites. There are multiple parking spaces visible in front of the building.
A hotel patio with a gazebo, outdoor seating, and a view of the road.
A hotel entrance with a large tree, a well-maintained garden with various plants and flowers, and a parking lot.
An indoor swimming pool with tiled flooring, a seating area with chairs, and a staircase leading to a door.

7. Candlewood Suites Cape Girardeau by IHG

Candlewood Suites Cape Girardeau by IHG
1 mi from Saint Francis Medical Center
United States
Samuel
£74
includes taxes & fees
25 Oct - 26 Oct
Candlewood Suites Cape Girardeau by IHG
A hotel room with a bed, desk, chair, television, and two wall-mounted lamps.
A hotel room with a kitchenette, a bed, a dining table with chairs, a TV mounted on the wall, and a dresser.
A motel with multiple floors, a parking lot, and a staircase leading to the upper floors.
A hotel room with a large bed, two bedside tables, a nightstand, a telephone, and two wall-mounted lamps.

8. Town House Inn Cape Giradreau

Town House Inn Cape Giradreau
1.2 mi from Saint Francis Medical Center
United States
Hope
£62
includes taxes & fees
15 Oct - 16 Oct
Town House Inn Cape Giradreau
A spacious lobby with a large sectional sofa, multiple armchairs, and a coffee table. There is a TV mounted on the wall and a large window providing a view of the outdoors.
An indoor swimming pool with a wooden ceiling, lounge chairs, and a lifeguard chair.
A hotel room with two beds, a brick wall, and a wooden headboard.
A Drury Inn & Suites building with a traditional architectural style, featuring a covered entrance and multiple windows.

9. Drury Inn & Suites Jackson MO

Drury Inn & Suites Jackson MO
9.5 mi from Saint Francis Medical Center
United States
Debra S
£64
includes taxes & fees
18 Oct - 19 Oct
Drury Inn & Suites Jackson MO
A spacious lobby with marble flooring, elegant seating, and a grand staircase.
A Courtyard by Marriott hotel with a modern brick facade, large windows, and a covered entrance area.
A modern hotel lobby with a framed advertisement for breakfast at the new Bistro, a seating area with sofas and a coffee table, and a decorative mirror reflecting the space.
A lobby with seating areas, a reception desk, and a bar.

10. Courtyard by Marriott Cape Girardeau Downtown

Courtyard by Marriott Cape Girardeau Downtown
2.7 mi from Saint Francis Medical Center
United States
Kristin
£107
includes taxes & fees
25 Oct - 26 Oct
Courtyard by Marriott Cape Girardeau Downtown
A modern retail area with a display of local items and snacks.
A hotel room with two beds, a desk, a chair, a TV, and a window with a view.
A modern lounge area with seating options including sofas, chairs, and a hanging chair, with large windows providing a view of the outdoors.
An outdoor patio area with seating arrangements, including a sofa and chairs, and a table.

11. Tru By Hilton Cape Girardeau

Tru By Hilton Cape Girardeau
3.5 mi from Saint Francis Medical Center
United States
Shannon
£77
includes taxes & fees
22 Oct - 23 Oct
Tru By Hilton Cape Girardeau
A spacious lobby with a curved staircase, large windows, and a seating area with a rug.
A modern bar area with a herringbone patterned wall, a long counter with bar stools, and a variety of bottles and glasses.
A hotel room with two beds, a desk, a chair, and a view of the city.
A modern outdoor seating area with a fire feature, a stone wall, and a view of the sunset.

12. The Riverview

The Riverview
3.1 mi from Saint Francis Medical Center
United States
Alyssa
£87
includes taxes & fees
21 Oct - 22 Oct
The Riverview
A hotel entrance with a large sign reading "LAQUINTA" and a sun graphic.
An outdoor patio with tables and chairs, a stone wall, and large windows.
A reception desk with a large mural of a bridge, wooden reception area, and a potted plant.
A breakfast bar with a coffee machine, waffle maker, toaster, and various food items.

13. La Quinta Inn & Suites by Wyndham Jackson/Cape Girardeau

La Quinta Inn & Suites by Wyndham Jackson/Cape Girardeau
4.1 mi from Saint Francis Medical Center
United States
Elaine
£65
includes taxes & fees
1 Nov - 2 Nov
La Quinta Inn & Suites by Wyndham Jackson/Cape Girardeau
A spacious lobby with large windows, comfortable seating, and a modern ceiling design.
A gym with treadmills, an elliptical, a bench, and a rack of dumbbells.
A breakfast bar with coffee machines, a cereal dispenser, and a fruit display.
A room with large windows, two red upholstered chairs, a small table, and a potted plant.

14. Comfort Suites Jackson-Cape Girardeau

Comfort Suites Jackson-Cape Girardeau
4.2 mi from Saint Francis Medical Center
United States
VICTORIA
£62
includes taxes & fees
4 Nov - 5 Nov
Comfort Suites Jackson-Cape Girardeau
A spacious living area with a high ceiling, a green accent wall, and a wooden balcony railing.
A hotel room with a flat-screen TV, a microwave, a sofa, a lamp, and a window with curtains.
A hotel room with a large bathtub, a bed with a wooden headboard, a nightstand with a lamp, and a painting of a building on the wall.
A restaurant with multiple tables and chairs, an exit sign, a television, and a counter with food items.

15. Quality Inn Cape Girardeau North

Quality Inn Cape Girardeau North
2.3 mi from Saint Francis Medical Center
United States
Dayanita
£51
includes taxes & fees
1 Nov - 2 Nov
Quality Inn Cape Girardeau North
View all properties

Compare popular hotels close to Saint Francis Medical Center

Property
Property class
Guest rating
Breakfast included
Pool
Spa
Pet-friendly
WiFi included
A spacious lobby with a circular seating area, a stone fireplace, and modern lighting fixtures.
Drury Plaza Hotel Cape Girardeau Conference Center
9.6
Exceptional
1,001 reviews
View
A spacious dining area with high ceilings, large windows, and modern lighting fixtures.
Hampton Inn Cape Girardeau I 55 East
9.6
Exceptional
852 reviews
View
A hotel room with a large bed, two bedside lamps, a chair, and a wooden headboard.
Drury Inn & Suites Cape Girardeau
9.4
Exceptional
1,007 reviews
View
A modern living room with a sofa, armchairs, a coffee table, and a TV mounted on the wall.
Fairfield Inn & Suites by Marriott Cape Girardeau
9.4
Exceptional
236 reviews
View
A spacious lobby with a fireplace, comfortable seating, a staircase, and a large chandelier.
Holiday Inn Express Hotel & Suites Cape Girardeau I-55 by IHG
9.4
Exceptional
1,000 reviews
View

Top Saint Francis Medical Center Hotel Reviews

Pear Tree Inn Cape Girardeau West

Pear Tree Inn Cape Girardeau West

8/10 Good
"bring spare plastic bags for trash and dirty laundry."
W 1-night trip
Posted less than an hour ago
Pear Tree Inn Cape Girardeau West
Holiday Inn Express Hotel & Suites Cape Girardeau I-55 by IHG

Holiday Inn Express Hotel & Suites Cape Girardeau I-55 by IHG

10/10 Excellent
"We have stayed here a number of times over 20 years. It’s always clean and well maintained. Breakfast is very good. Staff is always friendly and helpful."
John 3-night trip
Posted 21 hours ago
Holiday Inn Express Hotel & Suites Cape Girardeau I-55 by IHG
Drury Inn & Suites Cape Girardeau

Drury Inn & Suites Cape Girardeau

10/10 Excellent
"The food was excellent"
DENNIS 2-night trip
Posted 2 days ago
Drury Inn & Suites Cape Girardeau
The Riverview

The Riverview

10/10 Excellent
"."
Laura 1-night trip
Posted 2 days ago
The Riverview
Quality Inn Cape Girardeau North

Quality Inn Cape Girardeau North

10/10 Excellent
"All in all, wasn't too bad. Is time for some renovation."
David 1-night trip
Posted 5 days ago
Quality Inn Cape Girardeau North
The Twisted Sassafras Treehouse

The Twisted Sassafras Treehouse

10/10 Excellent
"What a perfect place to celebrate our 1st year wedding anniversary! Beautiful treehouse and very well thought out. Great first time experience. And out of the way yet close to Cape access to restaurants and entertainment if you choose. Will definitely recommend to others"
Jan S. 1-night trip
Posted 8 days ago
The Twisted Sassafras Treehouse
3 Bed 3 Bath Beautiful Historic District Within Walking Downtown Cape Girardeau

3 Bed 3 Bath Beautiful Historic District Within Walking Downtown Cape Girardeau

10/10 Excellent
"Everything was as expected and went very smoothly."
Brandon M. 2-night trip
Posted 9 days ago
3 Bed 3 Bath Beautiful Historic District Within Walking Downtown Cape Girardeau
“Brickyard”-Recently Remodeled Dutch Colonial Revival in Downtown Cape Girardeau

“Brickyard”-Recently Remodeled Dutch Colonial Revival in Downtown Cape Girardeau

10/10 Excellent
"We’ve been staying at Chip’s house the past two years during the fair! It’s always comfy and cozy! Chip’s fabulous!"
Jeff O. 9-night trip
Posted 2 weeks ago
“Brickyard”-Recently Remodeled Dutch Colonial Revival in Downtown Cape Girardeau
Hampton Inn Cape Girardeau I 55 East

Hampton Inn Cape Girardeau I 55 East

8/10 Good
"Liked the cleanliness of the room, and every time my family left or when returning to our room the staff said hello. What I didn’t like there were a lot of ants in the room where the especially by the TV and desks."
Valarie 2-night trip
Posted 2 weeks ago
Hampton Inn Cape Girardeau I 55 East

Frequently asked questions

What's the area like around Saint Francis Medical Center?
Saint Francis Medical Center is located in Cape Girardeau. This family-friendly area is known for its array of dining options. If you're looking for a convenient place to stay, take a look at the 8 hotels and other accommodation options you'll find within a mile.
What's the best hotel to stay near Saint Francis Medical Center?
Drury Plaza Hotel Cape Girardeau Conference Center is one of the top choices for your stay based on our traveller data, and this hotel offers free breakfast and a restaurant. It's located just a short 0.5 mi (0.8 km) from Saint Francis Medical Center. Other good choices within a short distance include Pear Tree Inn Cape Girardeau West and Holiday Inn Express Hotel & Suites Cape Girardeau I-55 by IHG.
How many hotels are there close to Saint Francis Medical Center?
Expedia has 8 hotels and other accommodation options within a mile from Saint Francis Medical Center.
If I need to cancel the hotel reservation for my stay near Saint Francis Medical Center, will I receive a refund?
Yes! The majority of hotel room reservations are refundable if you cancel prior to the hotel's cancellation deadline, which often is within 24-48 hours of your scheduled arrival. If you have a non-refundable reservation, you might still have the option to cancel and receive a refund within 24 hours of booking. Put your dates in and click on "Search", then filter by "fully refundable" to review the best options available near Saint Francis Medical Center.
What can I see and do near Saint Francis Medical Center?
You might spend a leisurely day outdoors at Fort D Historic Site and Cape Rock Park. Create some family memories at Cape Splash Family Aquatic Center and Cape Girardeau Conservation Nature Center. You might plan a visit to Show Me Center or eDen Spa & Salon while you're in the area.