Title: Saint Francis Healthcare System in Cape Girardeau | Expedia.co.uk [Saint Francis Healthcare System Hotels](https://expedia.co.uk/Saint-Francis-Healthcare-System-Hotels.0-l624549906283180032-0.Travel-Guide-Filter-Hotels)[Flights to Cape Girardeau](https://expedia.co.uk/Cheap-Flights-To-Cape-Girardeau.d820.Travel-Guide-Flights)[Saint Francis Healthcare System Car Hire](https://expedia.co.uk/Compare-Cheap-Car-Hire-In-Saint-Francis-Healthcare-System.d624549906283180032.Car-Hire-Guide)[Cape Girardeau Holidays](https://expedia.co.uk/Cape-Girardeau.d820.Holidays-City-Breaks) # Saint Francis Healthcare System ## Visit Saint Francis Healthcare System Activities [Cape Girardeau travel guide](https://expedia.co.uk/Cape-Girardeau.dx820) --- --- ### Popular places to visit ![Panorama of Academic Hall, Southeast Missouri State University ](https://images.trvl-media.com/place/553248621554122994/3bc9a5e0-c92b-4ca4-b94a-564376156913.jpg?impolicy=fcrop&w=900&h=506&q=mediumHigh) #### Southeast Missouri State University Take a campus tour or just explore the area of Southeast Missouri State University during your trip to Cape Girardeau. While in this family-friendly area, you can savour the top-notch restaurants. [](https://expedia.co.uk/Southeast-Missouri-State-University-Cape-Girardeau.d553248621554122994.Attraction) ![View of the Christopher S. Bond Bridge over Missouri River in Kansas City, from the riverfront park](https://images.trvl-media.com/place/553248621532655774/ae18e765-2c28-4c35-b4b0-74f1aaedcb22.jpg?impolicy=fcrop&w=900&h=506&q=mediumHigh) #### Riverfront Bridge Park Riverfront Bridge Park is just one of the places to see in Cape Girardeau, so why not enjoy the other things to explore during your travels? While in this family-friendly area, you can savour the top-notch restaurants. [](https://expedia.co.uk/Riverfront-Bridge-Park-Cape-Girardeau.d553248621532655774.Attraction) #### Cape Splash Family Aquatic Center Bring the children to Cape Splash Family Aquatic Center and have a fun-filled day at this theme park in Cape Girardeau. While in this family-friendly area, you can savour the top-notch restaurants. [](https://expedia.co.uk/Cape-Splash-Family-Aquatic-Center-Cape-Girardeau.d553248621532655772.Attraction) #### Cape Girardeau Conservation Nature Center Enjoy an outing to Cape Girardeau Conservation Nature Center during your stay in Cape Girardeau. While in this family-friendly area, you can savour the top-notch restaurants. [](https://expedia.co.uk/Cape-Girardeau-Conservation-Nature-Center-Cape-Girardeau.d553248621532655773.Attraction) #### Saint Francis Medical Center If Saint Francis Medical Center is what brings you to town, hopefully you'll have a chance to explore more of Cape Girardeau. [](https://expedia.co.uk/Saint-Francis-Healthcare-System-Sikeston.d624549286174855168.Attraction) #### Southeast Missouri Hospital If Southeast Missouri Hospital is what brings you to town, hopefully you'll have a chance to explore more of Cape Girardeau. [](https://expedia.co.uk/Southeast-Missouri-Hospital-Sikeston.d624551713624100864.Attraction) --- ## Top Hotel Deals ## Check availability on hotels close to Saint Francis Healthcare System [Tonight ](https://expedia.co.uk/Hotel-Search?rfrrid=TG.LP.CheckPrices.Package&adults=2&openPlayBack=true®ionId=624549906283180032&startDate=2026-03-29&endDate=2026-03-30)[29 Mar - 30 Mar](https://expedia.co.uk/Hotel-Search?rfrrid=TG.LP.CheckPrices.Package&adults=2&openPlayBack=true®ionId=624549906283180032&startDate=2026-03-29&endDate=2026-03-30) [Tomorrow night ](https://expedia.co.uk/Hotel-Search?rfrrid=TG.LP.CheckPrices.Package&adults=2&openPlayBack=true®ionId=624549906283180032&startDate=2026-03-30&endDate=2026-03-31)[30 Mar - 31 Mar](https://expedia.co.uk/Hotel-Search?rfrrid=TG.LP.CheckPrices.Package&adults=2&openPlayBack=true®ionId=624549906283180032&startDate=2026-03-30&endDate=2026-03-31) [Next weekend ](https://expedia.co.uk/Hotel-Search?rfrrid=TG.LP.CheckPrices.Package&adults=2&openPlayBack=true®ionId=624549906283180032&startDate=03%2F04%2F2026&endDate=05%2F04%2F2026)[3 Apr - 5 Apr](https://expedia.co.uk/Hotel-Search?rfrrid=TG.LP.CheckPrices.Package&adults=2&openPlayBack=true®ionId=624549906283180032&startDate=03%2F04%2F2026&endDate=05%2F04%2F2026) ![Drury Plaza Hotel Cape Girardeau Conference Center](https://images.trvl-media.com/lodging/18000000/17270000/17270000/17269948/5929e46c_y.jpg?impolicy=resizecrop&rw=340&ch=150) ### Drury Plaza Hotel Cape Girardeau Conference Center 3351 Percy Drive Cape Girardeau MO [](https://expedia.co.uk/Sikeston-Hotels-Drury-Plaza-Hotel-Cape-Girardeau-Conference-Center.h17269948.Hotel-Information) ![The Riverview](https://images.trvl-media.com/lodging/106000000/105090000/105081400/105081384/d68c9046_y.jpg?impolicy=resizecrop&rw=340&ch=150) ### The Riverview 777 Main St Cape Girardeau MO [](https://expedia.co.uk/Cape-Girardeau-Hotels-The-Riverview.h105081384.Hotel-Information) ![Drury Inn & Suites Cape Girardeau](https://images.trvl-media.com/lodging/1000000/50000/40900/40831/6966efed_y.jpg?impolicy=resizecrop&rw=340&ch=150) ### Drury Inn & Suites Cape Girardeau 3303 Campster Drive Cape Girardeau MO [](https://expedia.co.uk/Sikeston-Hotels-Drury-Inn-Suites-Cape-Girardeau.h40831.Hotel-Information) ![La Quinta Inn & Suites by Wyndham Jackson/Cape Girardeau](https://images.trvl-media.com/lodging/54000000/53350000/53348100/53348099/47fa1edf_y.jpg?impolicy=resizecrop&rw=340&ch=150) ### La Quinta Inn & Suites by Wyndham Jackson/Cape Girardeau 3003 SOUTH OLD ORCHARD ROAD Jackson MO [](https://expedia.co.uk/Jackson-Hotels-La-Quinta-Inn-Suites-By-Wyndham-JacksonCape-Girardeau.h53348099.Hotel-Information) ![Quality Inn Cape Girardeau North](https://images.trvl-media.com/lodging/1000000/860000/856000/855988/d2a0e781_y.jpg?impolicy=resizecrop&rw=340&ch=150) ### Quality Inn Cape Girardeau North 2011 North Kingshighway Cape Girardeau MO [](https://expedia.co.uk/Sikeston-Hotels-Quality-Inn.h855988.Hotel-Information) ![Pear Tree Inn Cape Girardeau West](https://images.trvl-media.com/lodging/1000000/30000/21500/21410/71011e95_y.jpg?impolicy=resizecrop&rw=340&ch=150) ### Pear Tree Inn Cape Girardeau West 103 Cape West Pkwy Cape Girardeau MO [](https://expedia.co.uk/Sikeston-Hotels-Pear-Tree-Inn-Cape-Girardeau-West.h21410.Hotel-Information) ![Holiday Inn Express Hotel & Suites Cape Girardeau I-55 by IHG](https://images.trvl-media.com/lodging/2000000/1280000/1278600/1278542/fe49057f_y.jpg?impolicy=resizecrop&rw=340&ch=150) ### Holiday Inn Express Hotel & Suites Cape Girardeau I-55 by IHG 3253 William Street Cape Girardeau MO [](https://expedia.co.uk/Sikeston-Hotels-Holiday-Inn-Express-Hotel-Suites-Cape-Girardeau-I-55.h1278542.Hotel-Information) ![Candlewood Suites Cape Girardeau by IHG](https://images.trvl-media.com/lodging/4000000/3540000/3530400/3530303/6afa6c85_y.jpg?impolicy=resizecrop&rw=340&ch=150) ### Candlewood Suites Cape Girardeau by IHG 485 S Mount Auburn Rd Cape Girardeau MO [](https://expedia.co.uk/Sikeston-Hotels-Candlewood-Suites-Cape-Girardeau.h3530303.Hotel-Information) ![Fairfield Inn & Suites by Marriott Cape Girardeau](https://images.trvl-media.com/lodging/100000000/99980000/99972100/99972043/8bb15ffe_y.jpg?impolicy=resizecrop&rw=340&ch=150) ### Fairfield Inn & Suites by Marriott Cape Girardeau 433 CAPE WEST CROSSINGS Cape Girardeau MO [](https://expedia.co.uk/Cape-Girardeau-Hotels-Fairfield-Inn-Suites-By-Marriott-Cape-Girardeau.h99972043.Hotel-Information) [See all 232 properties in Saint Francis Healthcare System](https://expedia.co.uk/Hotel-Search?rfrrid=TG.LP.Hotels.Package®ionId=624549906283180032) Lowest nightly price found within the past 24 hours based on a 1 night stay for 2 adults. 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