Photo by Leonardo De Leon

Search Hotels in Otay Mesa West, San Diego

Plan, book, stay with confidence

Be picky

Search almost a million properties worldwide

Treat yourself

Change your mind

Book hotels with free cancellation

Other neighbourhoods around Otay Mesa West

Hotels in top San Diego neighborhoods Learn more about Otay Mesa West

Downtown San Diego

2 out of top 10 points of interest in this area

4.5/5(138 area reviews)

Known for its fantastic nightlife, fascinating museums and beautiful waterfront views, there's plenty to explore in Downtown San Diego. Top attractions like Petco Park and USS Midway Museum are major draws. Catch the metro at Civic Center Station or Civic Center Station to see more of the city.

Find hotels in Downtown San Diego

Otay Mesa West Travel Info

Location	San Diego, United States of America
Similar neighbourhoods	Central San Diego, Mission Valley West and Midway District
Number of hotels	6,292
Known landmarks	Kaiser Permanente Otay Mesa Medical Offices
Hotels with family-friendly amenities	Motel 6 San Ysidro, CA - San Diego - Border and Valli Hi Motel

Frequently asked questions

What is Otay Mesa West like?

Otay Mesa West is a neighbourhood that travellers like for its cathedral.

What's the best accommodation in Otay Mesa West?

For your stay in Otay Mesa West, Lovely 1 bd 1 bth apartment fully furnished is one of the top choices based on our traveller data. Another good option for your stay in the area is 3 Bed 2 Bath Beautiful Home - 10 Mins from the Beach!.

How many hotels are there in the Otay Mesa West area?

When you want to find places to stay in San Diego, start by booking one of Expedia's 5 hotels and other accommodation options in Otay Mesa West.

If I need to cancel my hotel reservation in Otay Mesa West, will I receive a refund?

Yes! The majority of room reservations are refundable if you cancel before the hotel’s cancellation deadline, which is often 24 or 48 hours before the scheduled arrival. If you have a non-refundable reservation, you may still be able to cancel and receive a refund within 24 hours of your booking. Put your dates in and click on "Search", then you can use the "fully refundable" filter to review top deals in Otay Mesa West.

What is there to do around this San Diego neighbourhood?

A few places to visit in the area around Otay Mesa West include San Ysidro Border Crossing, Las Americas Premium Outlets and Aquatica. While you're out sightseeing in San Diego, make sure that you visit other sights such as Tijuana Customs - Garita El Chaparral or North Island Credit Union Amphitheatre.

How can I get around Otay Mesa West and the greater San Diego area?

Ready to get out and explore the city? Iris Avenue Trolley Station is the closest metro station.