Title: TOP Boutique Hotels in Ohio River Valley for 2025 | Expedia.co.uk [Ohio River Valley Travel Guide](https://expedia.co.uk/Ohio-River-Valley.dx6233674)[Hotels in Ohio River Valley](https://expedia.co.uk/Ohio-River-Valley-Hotels.d6233674.Travel-Guide-Hotels)[Holiday Rentals in Ohio River Valley](https://expedia.co.uk/Ohio-River-Valley-Holiday-Rentals.d6233674.Travel-Guide-HolidayRentals)[Flights to Ohio River Valley](https://expedia.co.uk/Cheap-Flights-To-Ohio-River-Valley.d6233674.Travel-Guide-Flights)[Ohio River Valley Car Hire](https://expedia.co.uk/Compare-Cheap-Car-Hire-In-Ohio-River-Valley.d6233674.Car-Hire-Guide)[Ohio River Valley Holidays](https://expedia.co.uk/Ohio-River-Valley.d6233674.Holidays-City-Breaks) ![Indianapolis featuring autumn colours and a cemetery](https://a.travel-assets.com/findyours-php/viewfinder/images/res70/25000/25344-Indianapolis.jpg?impolicy=fcrop&w=1200&h=500&q=medium) # Search Boutique Hotels in Ohio River Valley ![price find illustration](https://a.travel-assets.com/travel-assets-manager/pictogram-bex/light__price_find.svg) ### Change your mind Book hotels with free cancellation ![deals illustration](https://a.travel-assets.com/travel-assets-manager/pictogram-bex/light__deals.svg) ### Treat yourself Save instantly and earn perks with One Key [Learn about One Key](https://www.expedia.co.uk/welcome-one-key) ![bed illustration](https://a.travel-assets.com/travel-assets-manager/pictogram-bex/light__bed.svg) ### Be picky Search almost a million properties worldwide ## Check availability on Ohio River Valley Boutique Hotels Tonight [20 Sept - 21 Sept](https://www.expedia.co.uk/Hotel-Search?regionId=6233674&startDate=2025-09-20&endDate=2025-09-21&adults=2&propertyStyle=BOUTIQUE&rfrr=TG.LP.CheckPrices.Hotel&openPlayBack=true) Tomorrow [21 Sept - 22 Sept](https://www.expedia.co.uk/Hotel-Search?regionId=6233674&startDate=2025-09-21&endDate=2025-09-22&adults=2&propertyStyle=BOUTIQUE&rfrr=TG.LP.CheckPrices.Hotel&openPlayBack=true) Next weekend [26 Sept - 28 Sept](https://www.expedia.co.uk/Hotel-Search?regionId=6233674&startDate=2025-09-26&endDate=2025-09-28&adults=2&propertyStyle=BOUTIQUE&rfrr=TG.LP.CheckPrices.Hotel&openPlayBack=true) In two weeks [3 Oct - 5 Oct](https://www.expedia.co.uk/Hotel-Search?regionId=6233674&startDate=2025-10-03&endDate=2025-10-05&adults=2&propertyStyle=BOUTIQUE&rfrr=TG.LP.CheckPrices.Hotel&openPlayBack=true) ## Top Ohio River Valley Boutique Hotels ![Lobby](https://images.trvl-media.com/lodging/1000000/10000/9900/9861/840e31de.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Bar (on property)](https://images.trvl-media.com/lodging/1000000/10000/9900/9861/4fd8456f.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Interior](https://images.trvl-media.com/lodging/1000000/10000/9900/9861/2a2a7fb6.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Interior](https://images.trvl-media.com/lodging/1000000/10000/9900/9861/f0221042.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ### The Brown Hotel Downtown Louisville 9.4/10 Exceptional (1069) "Would definitely stay here again" [](https://www.expedia.co.uk/Louisville-Hotels-The-Brown-Hotel.h9861.Hotel-Information) ![1 bedroom, Egyptian cotton sheets, premium bedding, in-room safe](https://images.trvl-media.com/lodging/6000000/5290000/5287100/5287002/e40ec4ea.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Hallway](https://images.trvl-media.com/lodging/6000000/5290000/5287100/5287002/25619903.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Reception](https://images.trvl-media.com/lodging/6000000/5290000/5287100/5287002/083528eb.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Exterior](https://images.trvl-media.com/lodging/6000000/5290000/5287100/5287002/5b64e900.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ### 21c Museum Hotel Cincinnati Downtown Cincinnati 8.8/10 Excellent (1005) "Quick check in and gracious welcomes!" £145 includes taxes & fees 21 Sept - 22 Sept [](https://www.expedia.co.uk/Cincinnati-Hotels-21c-Museum-Hotel-Cincinnati.h5287002.Hotel-Information) ![Front of property](https://images.trvl-media.com/lodging/2000000/1420000/1413400/1413350/a9b7038a.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Interior](https://images.trvl-media.com/lodging/2000000/1420000/1413400/1413350/22b7d23e.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Room (Asleep in the Cyclone) | Premium bedding, down duvets, minibar, in-room safe](https://images.trvl-media.com/lodging/2000000/1420000/1413400/1413350/fdd94051.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Fountain](https://images.trvl-media.com/lodging/2000000/1420000/1413400/1413350/864ff441.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ### 21c Museum Hotel Louisville Downtown Louisville 9.2/10 Wonderful (1003) "Love my stay at this unique musuem hotel!" £151 includes taxes & fees 5 Oct - 6 Oct [](https://www.expedia.co.uk/Louisville-Hotels-21c-Museum-Hotel-Louisville.h1413350.Hotel-Information) ![Front of property](https://images.trvl-media.com/lodging/11000000/10660000/10656500/10656466/ab0c13a5.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Suite, 1 King Bed with Sofa bed (Hardesty) | Private kitchenette | Fridge, microwave, coffee/tea maker](https://images.trvl-media.com/lodging/11000000/10660000/10656500/10656466/573e9242.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Suite, 1 King Bed with Sofa bed (Miller) | Individually decorated, individually furnished, iron/ironing board](https://images.trvl-media.com/lodging/11000000/10660000/10656500/10656466/6a2d7a53.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Cottage (Macbeth) | Exterior](https://images.trvl-media.com/lodging/11000000/10660000/10656500/10656466/e9d667ac.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ### Landoll's Mohican Castle Loudonville 8.8/10 Excellent (310) "Neat place" £195 includes taxes & fees 21 Sept - 22 Sept [](https://www.expedia.co.uk/Mansfield-Hotels-Landolls-Mohican-Castle.h10656466.Hotel-Information) ![Free daily full breakfast ](https://images.trvl-media.com/lodging/10000000/9680000/9678400/9678336/46279487.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Interior entrance](https://images.trvl-media.com/lodging/10000000/9680000/9678400/9678336/a276c9db.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Terrace/patio](https://images.trvl-media.com/lodging/10000000/9680000/9678400/9678336/76841ca5.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Front of property](https://images.trvl-media.com/lodging/10000000/9680000/9678400/9678336/ce1b7eaf.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ### Market Street Inn Jeffersonville 9.8/10 Exceptional (115) "We’ve stayed at this beautiful B&B twice. The location, charm, cleanliness, and staff make it an absolute treasure." £147 includes taxes & fees 5 Oct - 6 Oct [](https://www.expedia.co.uk/Louisville-Hotels-Market-Street-Inn.h9678336.Hotel-Information) ![Grand Suite with Deck | Balcony view](https://images.trvl-media.com/lodging/6000000/5200000/5190700/5190689/dfab44c1.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Room | Premium bedding, down duvets, free minibar, individually decorated](https://images.trvl-media.com/lodging/6000000/5200000/5190700/5190689/69a9fa93.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Lobby](https://images.trvl-media.com/lodging/6000000/5200000/5190700/5190689/543ffa6e.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Room | Living area | 50-inch flat-screen TV with cable channels, TV](https://images.trvl-media.com/lodging/6000000/5200000/5190700/5190689/83868763.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ### St Paul Hotel Wooster Wooster 9.6/10 Exceptional (249) "A modern boutique Hotel in an historic old town. Very close to good restaurants, too." £178 includes taxes & fees 21 Sept - 22 Sept [](https://www.expedia.co.uk/Mansfield-Hotels-St-Paul-Hotel-Wooster.h5190689.Hotel-Information) ![3 bars/lounges, rooftop bar, cocktail bar](https://images.trvl-media.com/lodging/9000000/8330000/8329200/8329138/f9ecae0d.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Exterior](https://images.trvl-media.com/lodging/9000000/8330000/8329200/8329138/3f5f63a1.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![3 bars/lounges, rooftop bar, cocktail bar](https://images.trvl-media.com/lodging/9000000/8330000/8329200/8329138/48809bd4.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Lobby](https://images.trvl-media.com/lodging/9000000/8330000/8329200/8329138/d59d898d.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ### Metropolitan at The 9, Autograph Collection Downtown Cleveland 9.0/10 Wonderful (906) "Great downtown location close to everything you need! The facility is nice and service was wonderful. " £160 includes taxes & fees 12 Oct - 13 Oct [](https://www.expedia.co.uk/Cleveland-Hotels-Metropolitan-At-The-9.h8329138.Hotel-Information) Lowest nightly price found within the past 24 hours based on a 1 night stay for 2 adults. Prices and availability subject to change. Additional terms may apply. [View all properties](https://expedia.co.uk/Hotel-Search?startDate=2025-10-04&endDate=2025-10-05®ionId=6233674&adults=2&specialized_stays_group_explore=boutique_property&sort=RECOMMENDED&openPlayBack=true) ## Top Ohio River Valley Hotel Reviews ![Galt House Hotel Trademark Collection by Wyndham](//images.trvl-media.com/lodging/1000000/200000/191500/191434/b5c46c3f_y.jpg) ### Galt House Hotel Trademark Collection by Wyndham 10/10 Excellent "Fastest and easiest check in! Very clean, quiet, and beautiful!" [](https://expedia.co.uk/Louisville-Hotels-Galt-House-Hotel-Trademark-Collection-By-Wyndham.h191434.Hotel-Information) ![I Hotel And Illinois Conference Center](//images.trvl-media.com/lodging/2000000/1900000/1897400/1897350/b24d7833_y.jpg) ### I Hotel And Illinois Conference Center 10/10 Excellent "This was a quick stop for us. Very clean, looks new and a great staff. Good breakfast and a great deal for the price we paid. If in the area, we will be back!" [](https://expedia.co.uk/Champaign-Hotels-I-Hotel-And-Conference-Center.h1897350.Hotel-Information) ![Ironworks Hotel Indy](//images.trvl-media.com/lodging/20000000/19300000/19294100/19294032/02753ebe_y.jpg) ### Ironworks Hotel Indy 10/10 Excellent "The hotel is amazing, clean, Beautifull design, I would love to come again, one of my favorite! 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