Title: The Best Hotels Closest to Odessa Regional Medical Center South Campus in Odessa - 2026 Updated Prices | Expedia.co.uk [Holiday Rentals in Odessa](https://expedia.co.uk/Odessa-Holiday-Rentals.d6138.Travel-Guide-HolidayRentals)[Flights to Odessa](https://expedia.co.uk/Cheap-Flights-To-Odessa.d6138.Travel-Guide-Flights)[Odessa Regional Medical Center South Campus Car Hire](https://expedia.co.uk/Compare-Cheap-Car-Hire-In-Odessa-Regional-Medical-Center-South-Campus.d624557412445270016.Car-Hire-Guide)[Odessa Regional Medical Center South Campus Holidays](https://expedia.co.uk/Odessa-Regional-Medical-Center-South-Campus-Odessa.d624557412445270016.Attraction) ![Default HTG hotel image](https://a.travel-assets.com/travel-assets-manager/fallback-images-brand/bex_lodging_v2.jpg?impolicy=fcrop&w=1200&h=500&q=medium) ![](https://a.travel-assets.com/travel-assets-manager/fallback-images-brand/bex_lodging_v2.jpg?impolicy=fcrop&w=1200&h=500&q=medium) - ![](https://a.travel-assets.com/travel-assets-manager/pictogram-bex/light__price_find.svg) ### Change your mind Book hotels with free cancellation - ![](https://a.travel-assets.com/travel-assets-manager/pictogram-bex/light__deals.svg) ### Treat yourself Save instantly and earn perks with One Key [Learn about One Key](https://www.expedia.co.uk/welcome-one-key) - ![](https://a.travel-assets.com/travel-assets-manager/pictogram-bex/light__bed.svg) ### Be picky Search almost a million properties worldwide ## Check prices for these dates Tonight [20 Jan - 21 Jan](https://www.expedia.co.uk/Hotel-Search?regionId=624557412445270016&startDate=2026-01-20&endDate=2026-01-21&adults=2&rfrr=TG.LP.CheckPrices.Hotel&openPlayBack=true) Tomorrow [21 Jan - 22 Jan](https://www.expedia.co.uk/Hotel-Search?regionId=624557412445270016&startDate=2026-01-21&endDate=2026-01-22&adults=2&rfrr=TG.LP.CheckPrices.Hotel&openPlayBack=true) This weekend [23 Jan - 25 Jan](https://www.expedia.co.uk/Hotel-Search?regionId=624557412445270016&startDate=2026-01-23&endDate=2026-01-25&adults=2&rfrr=TG.LP.CheckPrices.Hotel&openPlayBack=true) Next weekend [30 Jan - 1 Feb](https://www.expedia.co.uk/Hotel-Search?regionId=624557412445270016&startDate=2026-01-30&endDate=2026-02-01&adults=2&rfrr=TG.LP.CheckPrices.Hotel&openPlayBack=true) Recommended Price (low to high) Distance Property class ## Our top choices for Odessa Regional Medical Center South Campus hotels ![Lobby](https://images.trvl-media.com/lodging/37000000/36290000/36287900/36287889/973da8d2.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![View from property](https://images.trvl-media.com/lodging/37000000/36290000/36287900/36287889/ecb7cc81.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Outdoor pool, open 10:00 AM to 10:00 PM, pool cabanas (surcharge)](https://images.trvl-media.com/lodging/37000000/36290000/36287900/36287889/ddcb28d1.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Reception](https://images.trvl-media.com/lodging/37000000/36290000/36287900/36287889/2f4147db.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ### Odessa Marriott Hotel & Conference Center [](https://www.expedia.co.uk/Midland-Hotels-Odessa-Marriott-Hotel-Conference-Center.h36287889.Hotel-Information) 0.5 mi from Odessa Regional Medical Center South Campus 9.2/10 Wonderful (474 reviews) "Property was great but i would likw to reiterate breakfast is NOT free. Unless you are a Marriott platinum member. Its 75.00 dollars a day to have access to M Club where breakfast is served. " ![United States](https://a.travel-assets.com/egds/marks/flags/us.svg) Crystal £154 includes taxes & fees 13 Feb - 14 Feb [](https://www.expedia.co.uk/Midland-Hotels-Odessa-Marriott-Hotel-Conference-Center.h36287889.Hotel-Information) ![Lobby](https://images.trvl-media.com/lodging/30000000/29280000/29276400/29276350/da90876d.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Laundry room](https://images.trvl-media.com/lodging/30000000/29280000/29276400/29276350/db38770f.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Coffee service](https://images.trvl-media.com/lodging/30000000/29280000/29276400/29276350/9fb14a5f.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Free WiFi, bed sheets](https://images.trvl-media.com/lodging/30000000/29280000/29276400/29276350/5d21bc84.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ### Motel 6 Odessa, TX - 2nd Street [](https://www.expedia.co.uk/Midland-Hotels-Motel-6-Odessa.h29276350.Hotel-Information) 0.8 mi from Odessa Regional Medical Center South Campus 7.8/10 Good (509 reviews) "Clean room, nice place to lay your head after a 13 hour drive." ![United States](https://a.travel-assets.com/egds/marks/flags/us.svg) Carson £51 includes taxes & fees 25 Jan - 26 Jan [](https://www.expedia.co.uk/Midland-Hotels-Motel-6-Odessa.h29276350.Hotel-Information) ![Terrace/patio](https://images.trvl-media.com/lodging/37000000/36420000/36420000/36419967/5b6e46d2.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Lobby sitting area](https://images.trvl-media.com/lodging/37000000/36420000/36420000/36419967/af6d5bff.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Exterior](https://images.trvl-media.com/lodging/37000000/36420000/36420000/36419967/7b16fd22.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Free breakfast ](https://images.trvl-media.com/lodging/37000000/36420000/36420000/36419967/11045428.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ### Holiday Inn Express & Suites Odessa I-20 by IHG [](https://www.expedia.co.uk/Midland-Hotels-Holiday-Inn-Express-Suites-Odessa-I-20.h36419967.Hotel-Information) 1.9 mi from Odessa Regional Medical Center South Campus 8.8/10 Excellent (477 reviews) "The room was clean and comfortable. The staff were friendly and efficient. We enjoyed the breakfast." ![United States](https://a.travel-assets.com/egds/marks/flags/us.svg) Holly £86 includes taxes & fees 20 Feb - 21 Feb [](https://www.expedia.co.uk/Midland-Hotels-Holiday-Inn-Express-Suites-Odessa-I-20.h36419967.Hotel-Information) ![Lobby](https://images.trvl-media.com/lodging/13000000/12800000/12799200/12799169/d4723456.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Gym](https://images.trvl-media.com/lodging/13000000/12800000/12799200/12799169/aeff69f6.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Desk, laptop workspace, blackout curtains, iron/ironing board](https://images.trvl-media.com/lodging/13000000/12800000/12799200/12799169/741266b8.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Business centre](https://images.trvl-media.com/lodging/13000000/12800000/12799200/12799169/a270cc5d.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ### MainStay Suites Odessa I-20 [](https://www.expedia.co.uk/Midland-Hotels-MainStay-Suites.h12799169.Hotel-Information) 1.8 mi from Odessa Regional Medical Center South Campus 8.2/10 Very good (306 reviews) "Very clean very spacious rooms friendly staff loved it" ![United States](https://a.travel-assets.com/egds/marks/flags/us.svg) Jamayea £69 includes taxes & fees 31 Jan - 1 Feb [](https://www.expedia.co.uk/Midland-Hotels-MainStay-Suites.h12799169.Hotel-Information) ![Indoor pool](https://images.trvl-media.com/lodging/1000000/30000/22900/22820/3940e71b.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Lobby](https://images.trvl-media.com/lodging/1000000/30000/22900/22820/2da3512c.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Free daily buffet breakfast ](https://images.trvl-media.com/lodging/1000000/30000/22900/22820/f85f0d31.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Reception](https://images.trvl-media.com/lodging/1000000/30000/22900/22820/47969dd8.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ### SureStay Plus Hotel by Best Western Odessa [](https://www.expedia.co.uk/Odessa-Hotels-SureStay-Plus-Hotel-By-Best-Western-Odessa.h22820.Hotel-Information) 1.6 mi from Odessa Regional Medical Center South Campus 7.4/10 Good (78 reviews) "Very nice place to stay " ![United States](https://a.travel-assets.com/egds/marks/flags/us.svg) Jerry £72 includes taxes & fees 21 Jan - 22 Jan [](https://www.expedia.co.uk/Odessa-Hotels-SureStay-Plus-Hotel-By-Best-Western-Odessa.h22820.Hotel-Information) ![Rollaway beds, free WiFi](https://images.trvl-media.com/lodging/4000000/3600000/3592900/3592870/0595c90a.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Exterior](https://images.trvl-media.com/lodging/4000000/3600000/3592900/3592870/6e80192c.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Room, Non Smoking | Rollaway beds, free WiFi](https://images.trvl-media.com/lodging/4000000/3600000/3592900/3592870/121d5631.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Lobby sitting area](https://images.trvl-media.com/lodging/4000000/3600000/3592900/3592870/09897368.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ### Villa West Inn [](https://www.expedia.co.uk/Midland-Hotels-Villa-West-Inn.h3592870.Hotel-Information) 1.6 mi from Odessa Regional Medical Center South Campus 7.4/10 Good (179 reviews) "Clean room, clean toilet and good staffs." ![United States](https://a.travel-assets.com/egds/marks/flags/us.svg) Francis £51 includes taxes & fees 21 Jan - 22 Jan [](https://www.expedia.co.uk/Midland-Hotels-Villa-West-Inn.h3592870.Hotel-Information) ![Living area](https://images.trvl-media.com/lodging/90000000/89520000/89513100/89513048/ccd541a1.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Front of property](https://images.trvl-media.com/lodging/90000000/89520000/89513100/89513048/2a5ad87f.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Front of property](https://images.trvl-media.com/lodging/90000000/89520000/89513100/89513048/c07e8ba4.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Private kitchen](https://images.trvl-media.com/lodging/90000000/89520000/89513100/89513048/0f799872.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ### DELUX INN [](https://www.expedia.co.uk/Odessa-Hotels-DELUX-INN.h89513048.Hotel-Information) 1.5 mi from Odessa Regional Medical Center South Campus 6.8/10 (24 reviews) "Best hotel " ![United States](https://a.travel-assets.com/egds/marks/flags/us.svg) Poncho £56 includes taxes & fees 21 Jan - 22 Jan [](https://www.expedia.co.uk/Odessa-Hotels-DELUX-INN.h89513048.Hotel-Information) ![Blackout curtains, free WiFi, bed sheets](https://images.trvl-media.com/lodging/2000000/1030000/1030000/1029935/16a3ff33.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Coffee service](https://images.trvl-media.com/lodging/2000000/1030000/1030000/1029935/2fd1f905.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Vending machine](https://images.trvl-media.com/lodging/2000000/1030000/1030000/1029935/94ce3847.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Lobby](https://images.trvl-media.com/lodging/2000000/1030000/1030000/1029935/e567607e.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ### Motel 6 Odessa, TX [](https://www.expedia.co.uk/Midland-Hotels-Motel-6-Odessa.h1029935.Hotel-Information) 1.7 mi from Odessa Regional Medical Center South Campus 6.8/10 (554 reviews) "The room was very clean. And management was very helpful." ![United States](https://a.travel-assets.com/egds/marks/flags/us.svg) Bonnie £56 includes taxes & fees 25 Jan - 26 Jan [](https://www.expedia.co.uk/Midland-Hotels-Motel-6-Odessa.h1029935.Hotel-Information) ![BBQ/picnic Area](https://images.trvl-media.com/lodging/18000000/17060000/17059800/17059767/7d056864.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Exterior](https://images.trvl-media.com/lodging/18000000/17060000/17059800/17059767/7484a447.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Meeting facility](https://images.trvl-media.com/lodging/18000000/17060000/17059800/17059767/2a2c133e.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Free daily buffet breakfast ](https://images.trvl-media.com/lodging/18000000/17060000/17059800/17059767/1b501150.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ### Staybridge Suites Odessa - Interstate HWY 20 by IHG [](https://www.expedia.co.uk/Midland-Hotels-Staybridge-Suites-Odessa-Interstate-HWY-20.h17059767.Hotel-Information) 2.4 mi from Odessa Regional Medical Center South Campus 8.8/10 Excellent (149 reviews) "Very friendly staff. " ![United States](https://a.travel-assets.com/egds/marks/flags/us.svg) Todd £92 includes taxes & fees 15 Feb - 16 Feb [](https://www.expedia.co.uk/Midland-Hotels-Staybridge-Suites-Odessa-Interstate-HWY-20.h17059767.Hotel-Information) ![Seasonal outdoor pool, open 7:00 AM to 10:00 PM, pool loungers](https://images.trvl-media.com/lodging/38000000/37990000/37983200/37983198/579a433d.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Lobby](https://images.trvl-media.com/lodging/38000000/37990000/37983200/37983198/2c6c5015.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Free daily full breakfast ](https://images.trvl-media.com/lodging/38000000/37990000/37983200/37983198/6a321775.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Desk, blackout curtains, iron/ironing board, free cots/infant beds](https://images.trvl-media.com/lodging/38000000/37990000/37983200/37983198/06c70494.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ### Hawthorn Extended Stay by Wyndham Odessa [](https://www.expedia.co.uk/Midland-Hotels-Hawthorn-Suites-By-Wyndham-Odessa.h37983198.Hotel-Information) 2.5 mi from Odessa Regional Medical Center South Campus 8.6/10 Excellent (270 reviews) "Clean room, reasonable price and restaurant on site which was perfect after a long day of driving" ![United States](https://a.travel-assets.com/egds/marks/flags/us.svg) Kimberly £76 includes taxes & fees 24 Jan - 25 Jan [](https://www.expedia.co.uk/Midland-Hotels-Hawthorn-Suites-By-Wyndham-Odessa.h37983198.Hotel-Information) ![Exterior](https://images.trvl-media.com/lodging/6000000/5950000/5945500/5945465/54a4f53a.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Exterior](https://images.trvl-media.com/lodging/6000000/5950000/5945500/5945465/009a5b34.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Premium bedding, desk, soundproofing, iron/ironing board](https://images.trvl-media.com/lodging/6000000/5950000/5945500/5945465/f0bde07e.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Exterior](https://images.trvl-media.com/lodging/6000000/5950000/5945500/5945465/173e1b7a.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ### Candlewood Suites Odessa by IHG [](https://www.expedia.co.uk/Midland-Hotels-Candlewood-Suites-Odessa.h5945465.Hotel-Information) 2.5 mi from Odessa Regional Medical Center South Campus 8.6/10 Excellent (190 reviews) "Very nice, will stay again." ![United States](https://a.travel-assets.com/egds/marks/flags/us.svg) Marian £90 includes taxes & fees 23 Jan - 24 Jan [](https://www.expedia.co.uk/Midland-Hotels-Candlewood-Suites-Odessa.h5945465.Hotel-Information) ![Iron/ironing board, free WiFi, bed sheets](https://images.trvl-media.com/lodging/16000000/15860000/15858700/15858627/10e44b81.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Iron/ironing board, free WiFi, bed sheets](https://images.trvl-media.com/lodging/16000000/15860000/15858700/15858627/03e5f79c.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Laundry room](https://images.trvl-media.com/lodging/16000000/15860000/15858700/15858627/20c49550.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Front of property – evening/night](https://images.trvl-media.com/lodging/16000000/15860000/15858700/15858627/ba54c4fd.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ### Studio 6 Odessa, TX [](https://www.expedia.co.uk/Midland-Hotels-Studio-6-Odessa.h15858627.Hotel-Information) 2.5 mi from Odessa Regional Medical Center South Campus 8.0/10 Very good (249 reviews) "Clean and quiet " ![United States](https://a.travel-assets.com/egds/marks/flags/us.svg) Walter £60 includes taxes & fees 29 Jan - 30 Jan [](https://www.expedia.co.uk/Midland-Hotels-Studio-6-Odessa.h15858627.Hotel-Information) ![Indoor pool](https://images.trvl-media.com/lodging/4000000/3020000/3018400/3018314/2a26e0e2.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Desk, laptop workspace, blackout curtains, iron/ironing board](https://images.trvl-media.com/lodging/4000000/3020000/3018400/3018314/8e889ee6.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Fitness facility](https://images.trvl-media.com/lodging/4000000/3020000/3018400/3018314/284a4226.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Exterior](https://images.trvl-media.com/lodging/4000000/3020000/3018400/3018314/4a5d8da2.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ### Sonesta Essential Hotels Odessa [](https://www.expedia.co.uk/Midland-Hotels-Super-8-By-Wyndham-Odessa-TX.h3018314.Hotel-Information) 2.3 mi from Odessa Regional Medical Center South Campus 7.8/10 Good (758 reviews) "Nice place" ![United States](https://a.travel-assets.com/egds/marks/flags/us.svg) Jose £68 includes taxes & fees 21 Jan - 22 Jan [](https://www.expedia.co.uk/Midland-Hotels-Super-8-By-Wyndham-Odessa-TX.h3018314.Hotel-Information) ![Reception](https://images.trvl-media.com/lodging/1000000/860000/858200/858194/a06ced02.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Lobby lounge](https://images.trvl-media.com/lodging/1000000/860000/858200/858194/333a64f8.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Outdoor pool](https://images.trvl-media.com/lodging/1000000/860000/858200/858194/4ecb283a.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Exterior](https://images.trvl-media.com/lodging/1000000/860000/858200/858194/89208a82.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ### Fairfield Inn & Suites Odessa [](https://www.expedia.co.uk/Midland-Hotels-Fairfield-Inn-Suites-Odessa.h858194.Hotel-Information) 3 mi from Odessa Regional Medical Center South Campus 8.8/10 Excellent (414 reviews) "The rooms were clean and spacious. And the free breakfast was the best! I would totally stay here again. " ![United States](https://a.travel-assets.com/egds/marks/flags/us.svg) Tina £74 includes taxes & fees 8 Feb - 9 Feb [](https://www.expedia.co.uk/Midland-Hotels-Fairfield-Inn-Suites-Odessa.h858194.Hotel-Information) ![Premium Room, 1 King Bed, Balcony | Terrace/patio](https://images.trvl-media.com/lodging/10000000/9740000/9734200/9734121/db21e120.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Premium Room, 1 King Bed, Pool View | Premium bedding, pillow-top beds, desk, laptop workspace](https://images.trvl-media.com/lodging/10000000/9740000/9734200/9734121/2c3a59b2.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Lobby](https://images.trvl-media.com/lodging/10000000/9740000/9734200/9734121/de285e20.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Premium Room, 1 King Bed, Pool View | Premium bedding, pillow-top beds, desk, laptop workspace](https://images.trvl-media.com/lodging/10000000/9740000/9734200/9734121/e355c500.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ### MCM Elegante Hotel and Conference Center Odessa [](https://www.expedia.co.uk/Midland-Hotels-MCM-Elegante-Hotel-And-Conference-Center-Odessa.h9734121.Hotel-Information) 3.4 mi from Odessa Regional Medical Center South Campus 9.0/10 Wonderful (1,005 reviews) "Staff was amazing and amenities were outstanding. Airport shuttle was on time and convenient." ![United States](https://a.travel-assets.com/egds/marks/flags/us.svg) Brenda £86 includes taxes & fees 23 Jan - 24 Jan [](https://www.expedia.co.uk/Midland-Hotels-MCM-Elegante-Hotel-And-Conference-Center-Odessa.h9734121.Hotel-Information) ![BBQ/picnic Area](https://images.trvl-media.com/lodging/3000000/2610000/2602900/2602858/b82755e7.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Lobby](https://images.trvl-media.com/lodging/3000000/2610000/2602900/2602858/8f5f6f8e.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![In-room safe, desk, iron/ironing board, free cots/infant beds](https://images.trvl-media.com/lodging/3000000/2610000/2602900/2602858/71e07371.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Lobby sitting area](https://images.trvl-media.com/lodging/3000000/2610000/2602900/2602858/a1b70271.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ### TownePlace Suites by Marriott Odessa [](https://www.expedia.co.uk/Midland-Hotels-TownePlace-Suites-By-Marriott-Odessa.h2602858.Hotel-Information) 3.3 mi from Odessa Regional Medical Center South Campus 9.0/10 Wonderful (513 reviews) "Great service and breakfast was very good." ![United States](https://a.travel-assets.com/egds/marks/flags/us.svg) Iris £84 includes taxes & fees 6 Feb - 7 Feb [](https://www.expedia.co.uk/Midland-Hotels-TownePlace-Suites-By-Marriott-Odessa.h2602858.Hotel-Information) ![Desk, laptop workspace, blackout curtains, iron/ironing board](https://images.trvl-media.com/lodging/3000000/2450000/2442700/2442694/8fc75a19.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Free daily full breakfast ](https://images.trvl-media.com/lodging/3000000/2450000/2442700/2442694/6f0dafaa.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Lobby](https://images.trvl-media.com/lodging/3000000/2450000/2442700/2442694/b6bfc9f0.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Exterior](https://images.trvl-media.com/lodging/3000000/2450000/2442700/2442694/608e6014.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ### Comfort Inn & Suites, Odessa I-20 [](https://www.expedia.co.uk/Midland-Hotels-Comfort-Inn-And-Suites.h2442694.Hotel-Information) 2.5 mi from Odessa Regional Medical Center South Campus 7.8/10 Good (574 reviews) "Room was clean and comfortable " ![United States](https://a.travel-assets.com/egds/marks/flags/us.svg) Dolores £64 includes taxes & fees 8 Feb - 9 Feb [](https://www.expedia.co.uk/Midland-Hotels-Comfort-Inn-And-Suites.h2442694.Hotel-Information) ![Full-sized fridge, microwave](https://images.trvl-media.com/lodging/12000000/11250000/11244300/11244225/ec1392f3.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Interior](https://images.trvl-media.com/lodging/12000000/11250000/11244300/11244225/9f9f962d.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Shower, hair dryer, towels, soap](https://images.trvl-media.com/lodging/12000000/11250000/11244300/11244225/2883d33b.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Premium bedding, pillow-top beds, desk, free WiFi](https://images.trvl-media.com/lodging/12000000/11250000/11244300/11244225/2f16ed82.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ### Parkway Inn [](https://www.expedia.co.uk/Midland-Hotels-Parkway-Inn.h11244225.Hotel-Information) 2.7 mi from Odessa Regional Medical Center South Campus 8.2/10 Very good (40 reviews) "Staff was very friendly and the remodeled rooms were very comfortable and enjoyable! " ![United States](https://a.travel-assets.com/egds/marks/flags/us.svg) Eric £72 includes taxes & fees 21 Jan - 22 Jan [](https://www.expedia.co.uk/Midland-Hotels-Parkway-Inn.h11244225.Hotel-Information) ![Lobby](https://images.trvl-media.com/lodging/13000000/12270000/12266800/12266800/900081c0.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Iron/ironing board, cots/infant beds, rollaway beds, free WiFi](https://images.trvl-media.com/lodging/13000000/12270000/12266800/12266800/c0b2e641.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Iron/ironing board, cots/infant beds, rollaway beds, free WiFi](https://images.trvl-media.com/lodging/13000000/12270000/12266800/12266800/0e60b214.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Free daily on-the-go breakfast ](https://images.trvl-media.com/lodging/13000000/12270000/12266800/12266800/fc32a6ad.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ### Days Inn by Wyndham Odessa [](https://www.expedia.co.uk/Midland-Hotels-Days-Inn-By-Wyndham-Odessa.h12266800.Hotel-Information) 2.5 mi from Odessa Regional Medical Center South Campus 7.4/10 Good (234 reviews) "Good staff, clean room" ![United States](https://a.travel-assets.com/egds/marks/flags/us.svg) Michael £61 includes taxes & fees 24 Jan - 25 Jan [](https://www.expedia.co.uk/Midland-Hotels-Days-Inn-By-Wyndham-Odessa.h12266800.Hotel-Information) ![Restaurant](https://images.trvl-media.com/lodging/1000000/20000/18600/18517/c10b9f23.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Children’s play area – indoor](https://images.trvl-media.com/lodging/1000000/20000/18600/18517/8060dfd1.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Fitness facility](https://images.trvl-media.com/lodging/1000000/20000/18600/18517/f7b30bfc.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Exterior](https://images.trvl-media.com/lodging/1000000/20000/18600/18517/7b41ecd2.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ### MCM Grande Hotel FunDome Odessa [](https://www.expedia.co.uk/Midland-Hotels-MCM-Grande-Hotel-FunDome-Odessa.h18517.Hotel-Information) 3.6 mi from Odessa Regional Medical Center South Campus 8.6/10 Excellent (1,274 reviews) "Good fresh breakfast, clean room, friendly employees " ![United States](https://a.travel-assets.com/egds/marks/flags/us.svg) Yolanda £65 includes taxes & fees 5 Feb - 6 Feb [](https://www.expedia.co.uk/Midland-Hotels-MCM-Grande-Hotel-FunDome-Odessa.h18517.Hotel-Information) Lowest nightly price found within the past 24 hours based on a 1 night stay for 2 adults. Prices and availability subject to change. Additional terms may apply. [View all properties](https://expedia.co.uk/Hotel-Search?startDate=2026-02-03&endDate=2026-02-04®ionId=624557412445270016&adults=2&sort=RECOMMENDED&openPlayBack=true) ## Top Odessa Regional Medical Center South Campus Hotel Reviews ![MCM Grande Hotel FunDome Odessa](https://images.trvl-media.com/lodging/1000000/20000/18600/18517/c10b9f23_y.jpg) ### MCM Grande Hotel FunDome Odessa 10/10 Excellent "We had the Jacuzzi suites and they were amazing. Beds were very comfortable, I have a hard sleeping and no issues with the pillows and the bed. It was an amazing time with the playground, the indoor pool, the hot tub was great. Breakfast was amazing!! Many varieties to choose from as well as an omelet and waffle bar. This was the best choice to go for my daughters Sweet 16th birthday her party was in our room and it was an amazing weekend. OMG!! The staff was amazing, very helpful, very clean facility, I loved the Police on property made me felt even safer!! Thank you MCM for an amazing weekend" [](https://expedia.co.uk/Midland-Hotels-MCM-Grande-Hotel-FunDome-Odessa.h18517.Hotel-Information) ![Holiday Inn Odessa by IHG](https://images.trvl-media.com/lodging/2000000/1660000/1652900/1652839/c51ad69d_y.jpg) ### Holiday Inn Odessa by IHG 10/10 Excellent "We did not eat breakfast." [](https://expedia.co.uk/Midland-Hotels-Holiday-Inn-Odessa.h1652839.Hotel-Information) ![MCM Elegante Hotel and Conference Center Odessa](https://images.trvl-media.com/lodging/10000000/9740000/9734200/9734121/e03442b2_y.jpg) ### MCM Elegante Hotel and Conference Center Odessa 10/10 Excellent "Yes" [](https://expedia.co.uk/Midland-Hotels-MCM-Elegante-Hotel-And-Conference-Center-Odessa.h9734121.Hotel-Information) ![Motel 6 Odessa, TX - 2nd Street](https://images.trvl-media.com/lodging/30000000/29280000/29276400/29276350/da90876d_y.jpg) ### Motel 6 Odessa, TX - 2nd Street 10/10 Excellent "We broke down Saturday night and needed a room because no mechanics open that late. Room was clean comfortable for our needs. Staff was efficient and friendly! Betty gave me a name for a Mechanic she trusted on Sunday when I had to ask to stay another night. Mechanic was still working on our truck Monday at check out! Betty gave us a later checkout so we didn’t have to sit in the cold! Definitely a place I recommend! If you stop in El Paso! " [](https://expedia.co.uk/Midland-Hotels-Motel-6-Odessa.h29276350.Hotel-Information) ![Studio 6 Odessa, TX](https://images.trvl-media.com/lodging/16000000/15860000/15858700/15858627/53d5751e_y.jpg) ### Studio 6 Odessa, TX 10/10 Excellent "Clean and quiet " [](https://expedia.co.uk/Midland-Hotels-Studio-6-Odessa.h15858627.Hotel-Information) ![Executive Inn Odessa](https://images.trvl-media.com/lodging/31000000/30670000/30661500/30661490/5c92bb91_y.jpg) ### Executive Inn Odessa 10/10 Excellent "Not a good location. It is in the industrial area of Odessa. " [](https://expedia.co.uk/Midland-Hotels-Executive-Inn-Odessa.h30661490.Hotel-Information) ![Parkway Inn](https://images.trvl-media.com/lodging/12000000/11250000/11244300/11244225/ec1392f3_y.jpg) ### Parkway Inn 10/10 Excellent "The place is very clean, but the bathroom towels had a strange smell..." [](https://expedia.co.uk/Midland-Hotels-Parkway-Inn.h11244225.Hotel-Information) ![Odessa Marriott Hotel & Conference Center](https://images.trvl-media.com/lodging/37000000/36290000/36287900/36287889/ddcb28d1_y.jpg) ### Odessa Marriott Hotel & Conference Center 10/10 Excellent "Clean Room and Great amenities" [](https://expedia.co.uk/Midland-Hotels-Odessa-Marriott-Hotel-Conference-Center.h36287889.Hotel-Information) ![Motel 6 Odessa, TX](https://images.trvl-media.com/lodging/2000000/1030000/1030000/1029935/8b539e14_y.jpg) ### Motel 6 Odessa, TX 10/10 Excellent "The room was very clean. And management was very helpful." [](https://expedia.co.uk/Midland-Hotels-Motel-6-Odessa.h1029935.Hotel-Information) ## Hotels near other Odessa Regional Medical Center South Campus attractions ### White-Pool House 4.3/5 (20 reviews) You can find out about the history of Odessa when you stop by White-Pool House. Experience the area's entertainment venues or attend a sporting event. [See properties](https://www.expedia.co.uk/Hotel-Search?rfrrid=TG.LP..PointOfInterests®ionId=553248621533114193) ### Parker House Museum 3.9/5 (53 reviews) You can spend time studying the exhibits at Parker House Museum in Odessa. While in this family-friendly area, you can savour the top-notch restaurants. [See properties](https://www.expedia.co.uk/Hotel-Search?rfrrid=TG.LP..PointOfInterests®ionId=6198194) ### Odessa Jackrabbit Statue You can learn about the history of Odessa when you stop by Odessa Jackrabbit Statue. While in this family-friendly area, you can savour the top-notch restaurants. [See properties](https://www.expedia.co.uk/Hotel-Search?rfrrid=TG.LP..PointOfInterests®ionId=951046741873315840) ### Globe of the Great Southwest 4.0/5 (56 reviews) You can get tickets for a performance at Globe of the Great Southwest on your trip to Odessa. While in this family-friendly area, you can savour the top-notch restaurants. [See properties](https://www.expedia.co.uk/Hotel-Search?rfrrid=TG.LP..PointOfInterests®ionId=6091889) ### McKinney Park 4.1/5 (85 reviews) Explore the great outdoors at McKinney Park, a lovely green space in Odessa. While in this family-friendly area, you can savour the top-notch restaurants. [See properties](https://www.expedia.co.uk/Hotel-Search?rfrrid=TG.LP..PointOfInterests®ionId=553248621561865664) ### Ellen Noel Art Museum 4.3/5 (8 reviews) You can browse the exhibits at Ellen Noel Art Museum, a museum with a story of its own, during your travels to Odessa. Experience the entertainment venues and theatre scene in this family-friendly area. [See properties](https://www.expedia.co.uk/Hotel-Search?rfrrid=TG.LP..PointOfInterests®ionId=6198192) ### Presidential Museum and Leadership Library 3.9/5 (62 reviews) You can browse the exhibits at Presidential Museum and Leadership Library, a museum with a story of its own, during your holiday in Odessa. Experience the entertainment venues and theatre scene in this family-friendly area. [See properties](https://www.expedia.co.uk/Hotel-Search?rfrrid=TG.LP..PointOfInterests®ionId=6198190) ### Music City Mall 4.1/5 (333 reviews) You can browse for the perfect souvenirs at Music City Mall during your trip to Odessa. Experience the entertainment venues and theatre scene in this family-friendly area. [See properties](https://www.expedia.co.uk/Hotel-Search?rfrrid=TG.LP..PointOfInterests®ionId=553248621561865667) ## Frequently asked questions ### What's the area like around Odessa Regional Medical Center South Campus? ### What's the best hotel to stay near Odessa Regional Medical Center South Campus? ### How many hotels will I be able to find close to Odessa Regional Medical Center South Campus? ### If I need to cancel the hotel reservation for my stay near Odessa Regional Medical Center South Campus, will I receive a refund? ### What can I see and do near Odessa Regional Medical Center South Campus?