Beginning of main content

Search 321,000 hotels worldwide.

Get the price guarantee available for your trip.

No Expedia cancellation fee to change or cancel almost any hotel reservation.


Top Trending Hotels Near John Wayne, Santa Ana

See all 1,036 Hotels in John Wayne

Get 200 Nectar points when you book your hotel

Simply enter your Nectar card number when prompted. Your points will be credited 30 days after you return from your trip.

Hotel Irvine

Hotel Irvine

17900 Jamboree Rd, Irvine
4.0 out of 5.0
Last booking: 1 hour ago
25 others viewing this property now

Situated near the airport, this eco-friendly hotel is 0.8 mi (1.3 km) from Boomers and 2.9 mi (4.7 km) from University of California-Irvine. Irvine Museum and ...

£101

£101
Ayres Hotel & Suites Costa Mesa/Newport Beach

Ayres Hotel & Suites Costa Mesa/Newport Beach

325 Bristol Street, Costa Mesa
4.5 out of 5.0
Last booking: 2 hours ago
22 others viewing this property now

Located in the heart of Costa Mesa, this hotel is 1.1 mi (1.7 km) from Tewinkle Park and 2.2 mi (3.6 km) from Segerstrom Center for the Arts. Lyon Air Museum ...

£103

£103
Great Wolf Lodge Garden Grove/Anaheim

Great Wolf Lodge Garden Grove/Anaheim

12681 Harbor Blvd, Garden Grove
3.5 out of 5.0
Last booking: 1 hour ago
109 others viewing this property now

Situated in Garden Grove, this spa resort is within 3 miles (5 km) of The Outlets at Orange, Disney California Adventure® Park and Disneyland®. Crystal Cathedral ...

£133

£133
The Resort at Pelican Hill

The Resort at Pelican Hill

22701 Pelican Hill Road S, Newport Beach
5.0 out of 5.0
Last booking: 20 hours ago
94 others viewing this property now

This family-friendly Newport Beach resort is located by the ocean, within 3 mi (5 km) of Crystal Cove, Sherman Library and Garden and Corona del Mar State Beach. ...

£235

£235
Anaheim Camelot Inn & Suites

Anaheim Camelot Inn & Suites

1520 S Harbor Blvd, Anaheim
3.5 out of 5.0
Last booking: 4 hours ago
51 others viewing this property now

Situated in the entertainment district, this hotel is within a 15-minute walk of Disney California Adventure® Park, Disneyland® and Downtown Disney® District. ...

£110

£110
Laguna Hills Inn by Irvine Spectrum

Laguna Hills Inn by Irvine Spectrum

23061 Avenida De La Carlota, Laguna Hills
3.0 out of 5.0
Last booking: 43 minutes ago
6 others viewing this property now

Situated in Laguna Hills, this hotel is 1.7 mi (2.7 km) from Laguna Hills Mall and 2.7 mi (4.4 km) from Irvine Spectrum Center. Saddleback Memorial Medical Center ...

£58

£58
Ayres Hotel Anaheim

Ayres Hotel Anaheim

2550 E Katella Ave, Anaheim
4.0 out of 5.0
Last booking: 9 minutes ago
39 others viewing this property now

Located in the heart of Anaheim, this hotel is within 1 mile (2 km) of Flightdeck Flight Simulation Center, Honda Center and Angel Stadium of Anaheim. Disney ...

£93

£93
Tropicana Inn and Suites

Tropicana Inn and Suites

1540 S Harbor Blvd, Anaheim
3.0 out of 5.0
Last booking: 44 minutes ago
29 others viewing this property now

Situated in Anaheim, this motel is within a 15-minute walk of Disney California Adventure® Park, Disneyland® and Downtown Disney® District. Angel Stadium of ...

£96

£96
BLVD Hotel, an Ascend Hotel Collection Member

BLVD Hotel, an Ascend Hotel Collection Member

2430 Newport Blvd, Costa Mesa
3.0 out of 5.0
Last booking: 4 hours ago

Situated near the airport, this motel is 0.7 mi (1.2 km) from Orange County Fairgrounds and 2.9 mi (4.7 km) from Segerstrom Center for the Arts. Tewinkle Park ...

£52

£52
Best Western Plus Newport Mesa Inn

Best Western Plus Newport Mesa Inn

2642 Newport Blvd, Costa Mesa
3.0 out of 5.0
Last booking: 18 minutes ago
11 others viewing this property now

Situated in Costa Mesa, this hotel is 0.4 mi (0.6 km) from Orange County Fairgrounds and 2.4 mi (3.8 km) from Segerstrom Center for the Arts. Tewinkle Park and ...

£71

£71