We have stayed here three or four times now, and this Centara is hard to fault. It's location is not ideal for Bangkok-bound tourists as it is quite a way from the centre of the city and the kinds of places you are likely to want to visit. But if, like us, you have specific needs or business in this part of Bangkok it is definitely the place to stay.
Having said that, outside of rush hour, twenty minutes or less will see you in Silom or Sukhumvit. Not bad by Bangkok standards!
The Centara chain is quite unpredictable (I've stayed at one that I wouldn't give more than two stars to), but the Ladprao one is superb. The rooms are terrific, the service good (and staff attitudes most commendable), and it has a true five-star ambience.
This visit, I booked a Club Deluxe Suite for THB5,800 -- excellent value. Because I wanted a smoking room we were upgraded to a slightly larger suite on the fifth floor with separate living/sleeping rooms. Other than a slightly odd layout to the bathroom, the room was well designed and in excellent condition. Very comfortable in every regard. And the Club Lounge is super -- wonderful service, great breakfast (unless you want Thai food), and terrific cocktail hour nibbles.
Connected to the hotel is the massive Ladprao Central shopping mall, and a 50 Baht cab ride away is Chatachuk Market where you could easily spend the whole weekend browsing the various departments.