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I go to Frankfurt every year for the same conference and I usually stay at the Marriott adjacent to Aparthotel. This was the first year I stayed at Aparthotel and I have definitely been missing out. You get way more for a much better price at the Aparthotel than at the Marriott. This is where I am ...
10 minutes from the airport - great central location but could do with cheaper local supermarket which was still a couple of streets away in the end but high room with a view made up for it.