Beginning of main content

Independent hotels in Downtown San Francisco, San Francisco

Search Flights

Trip Type
Flight 1
Flight 2
Flight 3
Flight 4
Flight 5

Downtown San Francisco Hotels

Search Flight + Hotel

Search 321,000 hotels worldwide.

Get the price guarantee available for your trip.

No Expedia cancellation fee to change or cancel almost any hotel reservation.


Featured Downtown San Francisco Independent Hotels

See all 177 Hotels in Downtown San Francisco
Serrano Hotel

Serrano Hotel

405 Taylor St, San Francisco
4.0 out of 5.0
3.9 out of 5 (1,560 reviews)
Pleasant stay in financial district. Parking garage across the street worked out great and eliminated the need for more expensive valet … - 

£124

£124
Hyatt Regency San Francisco

Hyatt Regency San Francisco

5 Embarcadero Center, San Francisco
4.0 out of 5.0
4.3 out of 5 (1,273 reviews)
We were please with our entire stay. It was my husband's birthday and we were treated by the reserv … - 

£176

£176
Handlery Union Square Hotel

Handlery Union Square Hotel

351 Geary St, San Francisco
3.5 out of 5.0
3.9 out of 5 (1,536 reviews)
Great customer service I love the location of the hotel and my stay was enjoyable. What took my experience over the top ho … - 

£137

£137
Hotel Whitcomb

Hotel Whitcomb

1231 Market St, San Francisco
3.5 out of 5.0
3.1 out of 5 (3,121 reviews)
Central location but old hotel The price for the location is great. It's within walking distance to union square or the tram. The … - 

£111

£111
Fairmont San Francisco

Fairmont San Francisco

950 Mason Street Atop Nob Hill, San Francisco
5.0 out of 5.0
4.4 out of 5 (2,008 reviews)
Our stay in San Francisco We had lovely time! What an amazing hotel. We had a marvelous time. - 

£155

£155
Chancellor Hotel on Union Square

Chancellor Hotel on Union Square

433 Powell St, San Francisco
3.0 out of 5.0
4.3 out of 5 (2,115 reviews)
Conveniently located and wonderful desk staff Everything was perfect. We asked for extra pillows and they were arrived in minutes. The bedding wa … - 

£152

£152
The Westin St Francis San Francisco on Union Square

The Westin St Francis San Francisco on Union Square

335 Powell Street, San Francisco
4.0 out of 5.0
4.1 out of 5 (1,771 reviews)
Great location to stay when visiting San Francisco Excellent location to take in all the sites in San Francisco. Easy access from SFO on the BART or a … - 

£150

£150
Grand Hyatt San Francisco Union Square

Grand Hyatt San Francisco Union Square

345 Stockton St, San Francisco
4.0 out of 5.0
4.3 out of 5 (1,343 reviews)
Very nice hotel in downtown San Francisco Very nice hotel and the staff was super friendly. The curbside staff (including valet) was excellen … - 

£158

£158
San Francisco Marriott Marquis

San Francisco Marriott Marquis

780 Mission Street, San Francisco
4.0 out of 5.0
4.4 out of 5 (1,613 reviews)
Great hotel centrally located to everything Staff was very helpful at all times. One single point of issue is the lobby restaurant. Its underst … - 

£138

£138
Monarch Hotel

Monarch Hotel

1015 Geary St, San Francisco
2.0 out of 5.0
3.1 out of 5 (1,012 reviews)
Nice hotel not too far from downtown San Francisco The hotel was very clean, the staff at the front desk were very welcoming and nice. Tea, coffees an … - 

£85

£85
Map

Recently booked Downtown San Francisco hotels

The Westin St Francis San Francisco on Union Square
4.0 out of 5.0
Last booking: 27 minutes ago
Americas Best Value Inn & Suites SoMa
2.0 out of 5.0
Last booking: 28 minutes ago
Hotel Zeppelin San Francisco
4.0 out of 5.0
Last booking: 32 minutes ago
The Marker San Francisco, a Joie de Vivre Hotel
4.0 out of 5.0
Last booking: 42 minutes ago
Clift
4.0 out of 5.0
Last booking: 44 minutes ago
Grand Hyatt San Francisco Union Square
4.0 out of 5.0
Last booking: 1 hour ago
JW Marriott San Francisco Union Square
4.0 out of 5.0
Last booking: 1 hour ago
The Cartwright Hotel - Union Square BW Premier Collection
3.5 out of 5.0
Last booking: 2 hours ago

Pocket Guide: Downtown San Francisco Independent Hotels

Search for hotels in Downtown San Francisco on Expedia.co.uk. You can easily find your hotels in Downtown San Francisco using one of the methods below:

  • View our selection of featured hotels in Downtown San Francisco
  • Use the map to find hotels in the Downtown San Francisco neighborhood you prefer
  • Use the filters to see hotels in a specific area of Downtown San Francisco, select a specific theme, brand, or hotel class from basic (1 Star) to luxury hotels (5 Stars) in Downtown San Francisco
  • Enter your travel dates to view the best deals on hotels in Downtown San Francisco - while they last