Beginning of main content

Downtown San Francisco hotel guide. Independent hotels in Downtown San Francisco, San Francisco

Search Flights

Trip Type
Flight 1
Flight 2
Flight 3
Flight 4
Flight 5

Downtown San Francisco Hotels

Search Flight + Hotel

Advanced options

Search 321,000 hotels worldwide.

Get the price guarantee available for your trip.

No Expedia cancellation fee to change or cancel almost any hotel reservation.


Featured Downtown San Francisco Independent Hotels

See all 172 Hotels in Downtown San Francisco
Inn At Union Square
Inn At Union Square
440 Post St, San Francisco
3.5 out of 5.0
4.6 out of 5 (418 reviews)
Short Trip in SF We were in SF for three days and wanted to be in downtown area (near Union Square) and chose this h … - 

£172

£172
Orchard Garden Hotel
Orchard Garden Hotel
466 Bush St, San Francisco
4.0 out of 5.0
4.5 out of 5 (604 reviews)
Close to China town and Union Square!. Great Location. Helpful and friendly staff. Excellent price. - 

£163

£163
Orchard Hotel
Orchard Hotel
665 Bush St, San Francisco
4.0 out of 5.0
4.6 out of 5 (800 reviews)
Would stay here again. Clean room, clean bed (mattress); which is paramount. Great location. Polite staff. - 

£145

£145
Villa Florence
Villa Florence
225 Powell St, San Francisco
4.0 out of 5.0
3.7 out of 5 (489 reviews)
Nice hotel convenient to union square and cable ca Nice hotel. Great staff, easy check in. Wifi was spotty, I would expect better since you pay extra … - 

£121

£121
Tilden Hotel
Tilden Hotel
345 Taylor St, San Francisco
3.5 out of 5.0
3.2 out of 5 (79 reviews)
Comfortable clean hotel for cheap This place is nice - has everything it needs. Not the fanciest hotel so set expectations accordingl … - 

£134

£134
Axiom Hotel San Francisco
Axiom Hotel San Francisco
28 Cyril Magnin Street, San Francisco
4.0 out of 5.0
4.4 out of 5 (140 reviews)
Great location and super friendly staff. The rooms are trendy. Overall was a great experience stayi … - 

£159

£159
White Swan Inn
White Swan Inn
845 Bush St, San Francisco
3.5 out of 5.0
4.5 out of 5 (302 reviews)
Great downtown location We were driving to San Francisco to visit my son in College and had no plans with no rooms booked a … - 

£172

£172
Hotel G San Francisco
Hotel G San Francisco
386 Geary Street, San Francisco
4.0 out of 5.0
4.1 out of 5 (456 reviews)
Great hotel with friendly and accommodating staff The hotel decor was modern yet rustic and the rooms are clean and comfortable. Being placed on a lo … - 

£152

£152
Serrano Hotel
Serrano Hotel
405 Taylor St, San Francisco
4.0 out of 5.0
4.0 out of 5 (1,486 reviews)
Nice hotel in dt good location, near union square asks 5th ave, Macy's, nice hotel in dt. price was not that high. - 

£93

£93
Map

Recently booked Downtown San Francisco hotels

Artmar Hotel
2.5 out of 5.0
Last booking: 5 minutes ago
Grand Hyatt San Francisco Union Square
4.0 out of 5.0
Last booking: 5 minutes ago
Villa Florence
4.0 out of 5.0
Last booking: 6 minutes ago
InterContinental Mark Hopkins
4.0 out of 5.0
Last booking: 11 minutes ago
Inn on Folsom
2.0 out of 5.0
Last booking: 15 minutes ago
Fairmont San Francisco
5.0 out of 5.0
Last booking: 16 minutes ago
Civic Center Motor Inn
2.0 out of 5.0
Last booking: 16 minutes ago
San Francisco Marriott Marquis
4.0 out of 5.0
Last booking: 20 minutes ago
Hotel EPIK
3.5 out of 5.0
Last booking: 29 minutes ago

Pocket Guide: Independent Hotels in Downtown San Francisco

Search for hotels in Downtown San Francisco on Expedia. You can easily find your hotels in Downtown San Francisco using one of the methods below:

  • View our selection of featured hotels in Downtown San Francisco
  • Use the map to find hotels in the Downtown San Francisco neighborhood you prefer
  • Use the filters to see hotels in a specific area of Downtown San Francisco, select a specific theme, brand, or hotel class from basic (1 Star) to luxury hotels (5 Stars) in Downtown San Francisco
  • Enter your travel dates to view the best deals on hotels in Downtown San Francisco - while they last