Beginning of main content
Trip Type
Flight 1
Flight 2
Flight 3
Flight 4
Flight 5

Search 321,000 hotels worldwide.

Get the best price available for your trip.

No Expedia cancellation fee to change or cancel almost any hotel reservation.


Featured Downtown San Francisco Hyatt Hotels Hotels

See all 180 Hotels in Downtown San Francisco
Hyatt Regency San Francisco

Hyatt Regency San Francisco

5 Embarcadero Center, San Francisco
4.5 out of 5.0
4.3 out of 5 (3,164 reviews)
Nice hotel at Embarcadero The hotel is in a great location, where you go in a walking distance to the City sites. Cable car i … - 

£119

£119
Grand Hyatt San Francisco Union Square

Grand Hyatt San Francisco Union Square

345 Stockton St, San Francisco
4.5 out of 5.0
4.4 out of 5 (3,345 reviews)
Very friendly hotel staff. Helped my husband find our room .... Let us have a late checkout. - 

£125

£125
Map

Recently booked Downtown San Francisco hotels

Civic Center Motor Inn
2.5 out of 5.0
Last booking: 1 hour ago
Adante Hotel, a C-Two Hotel
3.5 out of 5.0
Last booking: 2 hours ago
HTL 587, an Ascend Hotel Collection Member
3.0 out of 5.0
Last booking: 2 hours ago
Hotel Fusion, a C-Two Hotel
4.0 out of 5.0
Last booking: 2 hours ago
The Westin St. Francis San Francisco on Union Square
4.5 out of 5.0
Last booking: 2 hours ago
Hotel Union Square
4.0 out of 5.0
Last booking: 2 hours ago
Clift
4.5 out of 5.0
Last booking: 3 hours ago
San Francisco Marriott Marquis
4.5 out of 5.0
Last booking: 3 hours ago
W San Francisco
4.5 out of 5.0
Last booking: 3 hours ago

Pocket Guide: Downtown San Francisco Hyatt Hotels Hotels

Search for hotels in Downtown San Francisco on Expedia.co.uk. You can easily find your hotels in Downtown San Francisco using one of the methods below:

  • View our selection of featured hotels in Downtown San Francisco
  • Use the map to find hotels in the Downtown San Francisco neighborhood you prefer
  • Use the filters to see hotels in a specific area of Downtown San Francisco, select a specific theme, brand, or hotel class from basic (1 Star) to luxury hotels (5 Stars) in Downtown San Francisco
  • Enter your travel dates to view the best deals on hotels in Downtown San Francisco - while they last