Beginning of main content

Downtown San Francisco Hotel Guide - Business Hotel in Downtown San Francisco, San Francisco

Search Flights

Trip Type
Flight 1
Flight 2
Flight 3
Flight 4
Flight 5

Downtown San Francisco Hotels

Search Flight + Hotel

Advanced options

Search 321,000 hotels worldwide.

Get the price guarantee available for your trip.

No Expedia cancellation fee to change or cancel almost any hotel reservation.


Featured Downtown San Francisco Business Hotel

See all 172 Hotels in Downtown San Francisco
SF Plaza Hotel
SF Plaza Hotel
510 Bush Street, San Francisco
2.5 out of 5.0
2.6 out of 5 (247 reviews)
Hide review
Affordable, right next to Chinatown I stayed here for an American Chemical Society meeting. Affordable rooms get booked very quickly. This hotel is few blocks from Moscone Center and even closer to some of the other convention hotels, so it's a convenient location (especially in the great weather during the convention). Front desk ...
  6 Apr 2017

£129

£129
Monarch Hotel
Monarch Hotel
1015 Geary St, San Francisco
2.0 out of 5.0
3.1 out of 5 (963 reviews)
Hide review
Good enough! Got the JOB DONE. The staff was great, it's an old hotel, that's all there is too it. Imagine a very clean, very old, hotel. Staff was GREAT!
  22 May 2017

£85

£85
The Mosser
The Mosser
54 4th Street, San Francisco
2.5 out of 5.0
3.9 out of 5 (1,729 reviews)
Hide review
Cozy hip place in good spot Liked the location, the room was small but good for what we needed it for. Had a room with a private bathroom. Overall would stay again.
  25 May 2017

£76

£76
Civic Center Inn
Civic Center Inn
790 Ellis St, San Francisco
2.0 out of 5.0
1.9 out of 5 (545 reviews)
Hide review
Decent hotel near the Bill Graham Has free parking and is close to bill graham. Seems a little sketchy there's bums trash etc in the nearby streets. However, it makes up for it in the price and short walking distance to the bill graham and plenty of good food choices near by. The rooms are cleaner than other hotels I've stayed ...
  30 Jan 2017

£96

£96
Adrian Hotel
Adrian Hotel
493 Eddy Street, San Francisco
2.0 out of 5.0
3.0 out of 5 (199 reviews)
Hide review
Good hotel, strange neighborhood I enjoyed my stay at the Adrian. My room was comfortable and very clean. I chose to rent a room with communal bathrooms. The bathrooms were clean, but if I had the choice to do it over again, I would choose a bathroom simply because the communal bathrooms were often occupied. The neighborhood the ...
  21 Apr 2017

£66

£66
The Cartwright Hotel - Union Square BW Premier Collection
The Cartwright Hotel - Union Square BW Premier Collection
524 Sutter Street, San Francisco
3.5 out of 5.0
3.9 out of 5 (1,023 reviews)
Hide review
Nice clean little place to sleep. Firstly great location just a short walk to lots of public transport. Room was actually bigger than i expected having read a few reviews however bathroom is quite small. That being said the shower itself has some room so you wont be knocking your elbows. The heater didnt work at all the first night ...
  22 May 2017

£134

£134
Serrano Hotel
Serrano Hotel
405 Taylor St, San Francisco
4.0 out of 5.0
3.9 out of 5 (1,490 reviews)
Hide review
Nice place but more expensive than Expedia shows. There was an additional urban tax not shown on Expedia. Parking was also an additional $60/day. Staff and service were great. Lobby had strange smell. Room and bathroom were tiny with very little storage for clothing. There was no refrigerator or ...
  25 May 2017

£93

£93
Mithila Hotel
Mithila Hotel
972 Sutter St, San Francisco
2.0 out of 5.0
2.8 out of 5 (273 reviews)
Hide review
Close to Union Sq It was a pleasant hotel. It was a close walking distance to Union Sq and loads of eateries to choose from. Thoroughly enjoyed my time there. And a nice little history shared about the hotel by its staff. Overall I would consider staying here again.
  24 May 2017

£66

£66
Grant Plaza Hotel
Grant Plaza Hotel
465 Grant Ave, San Francisco
2.0 out of 5.0
3.2 out of 5 (755 reviews)
Hide review
Location!! This hotel has the perfect location. Right by Chinatown but only a block away from union square and hundreds of great restaurants and shopping in every direction. Staff super nice and helpful. Room very clean and great shower but bed could be a little more soft but that's literally the only negative ...
  18 May 2017

£101

£101
Map

Recently booked Downtown San Francisco hotels

Serrano Hotel
4.0 out of 5.0
Last booking: 5 minutes ago
Inn At Union Square
3.5 out of 5.0
Last booking: 13 minutes ago
Hotel Abri - Union Square
3.5 out of 5.0
Last booking: 13 minutes ago
JW Marriott San Francisco Union Square
4.0 out of 5.0
Last booking: 15 minutes ago
Kensington Park Hotel
3.5 out of 5.0
Last booking: 18 minutes ago
Executive Hotel Vintage Court
3.0 out of 5.0
Last booking: 28 minutes ago
Calista Organic Hotel
3.0 out of 5.0
Last booking: 44 minutes ago
Villa Florence
4.0 out of 5.0
Last booking: 47 minutes ago
Clift
4.0 out of 5.0
Last booking: 57 minutes ago

Pocket Guide: Business Hotel Hotels in Downtown San Francisco

Search for hotels in Downtown San Francisco on Expedia.co.uk. You can easily find your hotels in Downtown San Francisco using one of the methods below:

  • View our selection of featured hotels in Downtown San Francisco
  • Use the map to find hotels in the Downtown San Francisco neighborhood you prefer
  • Use the filters to see hotels in a specific area of Downtown San Francisco, select a specific theme, brand, or hotel class from basic (1 Star) to luxury hotels (5 Stars) in Downtown San Francisco
  • Enter your travel dates to view the best deals on hotels in Downtown San Francisco - while they last