Beginning of main content
Trip Type
Flight 1
Flight 2
Flight 3
Flight 4
Flight 5

Search 321,000 hotels worldwide.

Get the best price available for your trip.

No Expedia cancellation fee to change or cancel almost any hotel reservation.


Featured Downtown San Francisco Boutique Hotels

See all 183 Hotels in Downtown San Francisco
Mystic Hotel by Charlie Palmer

Mystic Hotel by Charlie Palmer

417 Stockton St, San Francisco
3.5 out of 5.0
4.0 out of 5 (2,362 reviews)
Great stay Had a great experience. Only downfall, the lady that checked me out seems to not have much knowledge of how the hotel works, how the parking works, or much else. Says she's been there for a few months but doesn't know how parking works. I checked out Sunday 11/5. That aside, I don't want to take ...
  10 Nov 2017

£111

£111
Hotel Diva

Hotel Diva

440 Geary St, San Francisco
3.5 out of 5.0
3.9 out of 5 (2,768 reviews)
Clean RoomStaff was very helpful, rooms were clean. Walking distance to Union Square
  20 Nov 2017

£85

£85
Hotel Rex San Francisco

Hotel Rex San Francisco

562 Sutter St, San Francisco
3.5 out of 5.0
4.2 out of 5 (1,619 reviews)
Great hotel, perfect location!After missing our flight, hotel Rex was so accommodating! Enjoyed our short stay, loved the Library Bar, & walked out the door into beautiful San Francisco Union Square!
  18 Nov 2017

£107

£107
The Marker San Francisco, a Joie de Vivre Hotel

The Marker San Francisco, a Joie de Vivre Hotel

501 Geary St, San Francisco
4.0 out of 5.0
4.4 out of 5 (2,183 reviews)
Nice and close to union sqrCloser to union square with tea and wine time with a confortable chimeney
  21 Nov 2017

£113

£113
Clift

Clift

495 Geary St, San Francisco
4.0 out of 5.0
4.1 out of 5 (3,916 reviews)
Perfect location to all my tech events Excellent location. Staff was super friendly. Breakfast in the velvet room was incredible. Stayed here at the recommendation of a friend. Will certainly stay again.
  22 Nov 2017

£121

£121
Villa Florence San Francisco on Union Square

Villa Florence San Francisco on Union Square

225 Powell St, San Francisco
4.0 out of 5.0
4.0 out of 5 (3,493 reviews)
Great location Great location, nice size room. Hotel is undergoing renovations.
  19 Nov 2017

£94

£94
The Scarlet Huntington Hotel

The Scarlet Huntington Hotel

1075 California St, San Francisco
4.5 out of 5.0
4.6 out of 5 (1,569 reviews)
Great location Hotel restaurant was wonderfulVery nice boutique hotel across from Grace Cathedral, a beautiful site atnight
  20 Nov 2017

£150

£150
Hotel Abri - Union Square

Hotel Abri - Union Square

127 Ellis Street, San Francisco
3.5 out of 5.0
4.2 out of 5 (2,508 reviews)
Great hotel close to all the main areasThe hotel was clean, the staff were friendly and helpful. Out TV and remote didn't work one night, we told the front desk and they promptly sent someone upstairs to fix it, which was great. I would definitely recommend.
  19 Nov 2017

£90

£90
Kensington Park Hotel

Kensington Park Hotel

450 Post St, San Francisco
3.5 out of 5.0
4.1 out of 5 (2,167 reviews)
Class and location Great hotel. Very friendly staff, comfortable rooms, good location.
  22 Nov 2017

£90

£90
Inn At Union Square - A Greystone Hotel

Inn At Union Square - A Greystone Hotel

440 Post St, San Francisco
3.5 out of 5.0
4.6 out of 5 (1,035 reviews)
OutstandingI can't remember using the word "Outstanding" in a review but this time it really seems appropriate. The combination of the room, the staff, and the location make it stand out in our experience (probably been to two dozen SF locations over the years). Not exactly sure how we ended up there since ...
  20 Nov 2017

£156

£156
Map

Recently booked Downtown San Francisco hotels

Hotel Nikko San Francisco
4.0 out of 5.0
Last booking: 4 minutes ago
Hotel Metropolis
3.0 out of 5.0
Last booking: 6 minutes ago
Serrano Hotel
4.0 out of 5.0
Last booking: 9 minutes ago
Park Central Hotel San Francisco, a Starwood Hotel
4.0 out of 5.0
Last booking: 18 minutes ago
Hampton Inn San Francisco Downtown/Convention Center
3.0 out of 5.0
Last booking: 22 minutes ago
COVA Hotel
3.0 out of 5.0
Last booking: 25 minutes ago
Hotel Whitcomb
3.5 out of 5.0
Last booking: 26 minutes ago
Phoenix Hotel, a Joie de Vivre Boutique Hotel
2.5 out of 5.0
Last booking: 27 minutes ago
The Opal San Francisco
2.5 out of 5.0
Last booking: 29 minutes ago

Pocket Guide: Boutique Hotels in Downtown San Francisco

Search for Boutique Hotels in Downtown San Francisco on Expedia.co.uk. You can easily find your Boutique Hotels in Downtown San Francisco using one of the methods below:

  • View our selection of featured hotels in Downtown San Francisco
  • Use the map to find budget hotels in the Downtown San Francisco neighborhood you prefer
  • Use the filters to see hotels in a specific area of Downtown San Francisco, select a specific theme, brand, or hotel class in Downtown San Francisco
  • Enter your travel dates to view the best deals on hotels in Downtown San Francisco - while they last