Title: Cheap Flights to Sancti Spiritu - Expedia.co.uk ![Default HTG hotel image](https://a.travel-assets.com/travel-assets-manager/fallback-images-brand/bex_flights_v2.jpg?impolicy=fcrop&w=1200&h=500&q=medium) ![](https://a.travel-assets.com/travel-assets-manager/fallback-images-brand/bex_flights_v2.jpg?impolicy=fcrop&w=1200&h=500&q=medium) # Cheap Flights to Sancti Spiritu - [Return](?flightType=roundtrip) - [One-way](?flightType=oneway) - [Multi-city](?flightType=multicity) ### Travellers Adults ChildrenAges 2 to 17 InfantsYounger than 2 EconomyPremium economyBusiness classFirst class Leaving from Going to Departing Add a place to stay Direct flights only [Hotels in Sancti Spiritu](https://expedia.co.uk/Sancti-Spiritu-Hotels.d553248635923281288.Travel-Guide-Hotels)[Sancti Spiritu Car Hire](https://expedia.co.uk/Compare-Cheap-Car-Hire-In-Sancti-Spiritu.d553248635923281288.Car-Hire-Guide)[Sancti Spiritu Holidays](https://expedia.co.uk/Sancti-Spiritu.d553248635923281288.Holidays-City-Breaks) ## Popular airlines to Sancti Spiritu - ![Aerolineas Argentinas](https://forever.travel-assets.com/flex/flexmanager/images/2024/09/23/landing_airline_sq_logo_AR.svg) Aerolineas Argentinas [](https://www.expedia.co.uk/Flights-Search?leg1=from:CMH,to:Sancti Spiritu, Santa Fe Province, Argentina,departure:29/09/2025TANYT&leg2=from:Sancti Spiritu, Santa Fe Province, Argentina,to:CMH,departure:06/10/2025TANYT&trip=roundtrip&passengers=adults:1,children:0,infantinlap:N&mode=search&pageId=0&filters=[{"preferredAirlineFilterValue":{"carrierCode":"AR"}}]) - ![LATAM Airlines Group](https://forever.travel-assets.com/flex/flexmanager/images/2024/09/23/landing_airline_sq_logo_LA.svg) LATAM Airlines Group [](https://www.expedia.co.uk/Flights-Search?leg1=from:CMH,to:Sancti Spiritu, Santa Fe Province, Argentina,departure:29/09/2025TANYT&leg2=from:Sancti Spiritu, Santa Fe Province, Argentina,to:CMH,departure:06/10/2025TANYT&trip=roundtrip&passengers=adults:1,children:0,infantinlap:N&mode=search&pageId=0&filters=[{"preferredAirlineFilterValue":{"carrierCode":"LA"}}]) - ![Copa](https://forever.travel-assets.com/flex/flexmanager/images/2024/09/23/landing_airline_sq_logo_CM.svg) Copa [](https://www.expedia.co.uk/Flights-Search?leg1=from:CMH,to:Sancti Spiritu, Santa Fe Province, Argentina,departure:29/09/2025TANYT&leg2=from:Sancti Spiritu, Santa Fe Province, Argentina,to:CMH,departure:06/10/2025TANYT&trip=roundtrip&passengers=adults:1,children:0,infantinlap:N&mode=search&pageId=0&filters=[{"preferredAirlineFilterValue":{"carrierCode":"CM"}}]) - ![GOL Linhas Aereas S.A.](https://forever.travel-assets.com/flex/flexmanager/images/2024/09/23/landing_airline_sq_logo_G3.svg) GOL Linhas Aereas S.A. [](https://www.expedia.co.uk/Flights-Search?leg1=from:CMH,to:Sancti Spiritu, Santa Fe Province, Argentina,departure:29/09/2025TANYT&leg2=from:Sancti Spiritu, Santa Fe Province, Argentina,to:CMH,departure:06/10/2025TANYT&trip=roundtrip&passengers=adults:1,children:0,infantinlap:N&mode=search&pageId=0&filters=[{"preferredAirlineFilterValue":{"carrierCode":"G3"}}]) - ![American Airlines](https://forever.travel-assets.com/flex/flexmanager/images/2024/09/23/landing_airline_sq_logo_AA.svg) American Airlines [](https://www.expedia.co.uk/Flights-Search?leg1=from:CMH,to:Sancti Spiritu, Santa Fe Province, Argentina,departure:29/09/2025TANYT&leg2=from:Sancti Spiritu, Santa Fe Province, Argentina,to:CMH,departure:06/10/2025TANYT&trip=roundtrip&passengers=adults:1,children:0,infantinlap:N&mode=search&pageId=0&filters=[{"preferredAirlineFilterValue":{"carrierCode":"AA"}}]) - ![KLM](https://forever.travel-assets.com/flex/flexmanager/images/2024/09/23/landing_airline_sq_logo_KL.svg) KLM [](https://www.expedia.co.uk/Flights-Search?leg1=from:CMH,to:Sancti Spiritu, Santa Fe Province, Argentina,departure:29/09/2025TANYT&leg2=from:Sancti Spiritu, Santa Fe Province, Argentina,to:CMH,departure:06/10/2025TANYT&trip=roundtrip&passengers=adults:1,children:0,infantinlap:N&mode=search&pageId=0&filters=[{"preferredAirlineFilterValue":{"carrierCode":"KL"}}]) - ![Aeromexico](https://forever.travel-assets.com/flex/flexmanager/images/2024/09/23/landing_airline_sq_logo_AM.svg) Aeromexico [](https://www.expedia.co.uk/Flights-Search?leg1=from:CMH,to:Sancti Spiritu, Santa Fe Province, Argentina,departure:29/09/2025TANYT&leg2=from:Sancti Spiritu, Santa Fe Province, Argentina,to:CMH,departure:06/10/2025TANYT&trip=roundtrip&passengers=adults:1,children:0,infantinlap:N&mode=search&pageId=0&filters=[{"preferredAirlineFilterValue":{"carrierCode":"AM"}}]) - ## Plan, book, fly with confidence - ### Be in the know Get alerts if flight prices drop or rise\* - ### Book smarter Save up to 25% on select hotels after you book a flight\* - ### Earn twice Earn your airline miles on top of our rewards [Sign in](https://www.expedia.co.uk/login) ## Expedia flights to Sancti Spiritu Searching for cheap flights to Sancti Spiritu? No travel company presents more choices than Expedia if you're looking to compare flights to Sancti Spiritu. With more airlines, cheaper flights, fewer stops, and more departure and arrival times travellers should ensure they search on Expedia before any holiday to Santa Fe Province. Expedia provides the cheapest flights to many destinations in Santa Fe Province and you may find even greater savings if you combine your flight with a hotel stay in Sancti Spiritu. Expedia is the largest online travel agency which means that Expedia have access to cheap flights. So make sure you check Expedia regularly for these bargain flights because the cheapest airline tickets sell out fast. Expedia is not only free for everyone to use but it quick and easy to use. Find the lowest flight prices guaranteed and book directly through Expedia. Browse through hundreds of cheap flight offers to find the one that suits your budget by simply inputting your travel dates. Expedia will then find the cheapest flights to Sancti Spiritu for that period and let you choose your preferred time and airline. If you need additional assistance, Expedia Customer Service representatives are available from 8am - 10pm Monday to Friday, and 9am - 10pm at weekends. Our capable staff will be able to help you with any questions regarding your Sancti Spiritu flight, or other booking questions that may arise. When you book flights with Expedia you can rest assured that you have booked the best flight at the lowest price. - Top Flights Destinations - Related Airlines ### Top Flight Destinations - [Flights to Buenos Aires](https://expedia.co.uk/Cheap-Flights-To-Buenos-Aires.d178242.Travel-Guide-Flights) - [Flights to Ushuaia](https://expedia.co.uk/Cheap-Flights-To-Ushuaia.d3654.Travel-Guide-Flights) - [Flights to El Calafate](https://expedia.co.uk/Cheap-Flights-To-El-Calafate.d6023812.Travel-Guide-Flights) - [Flights to San Carlos de Bariloche](https://expedia.co.uk/Cheap-Flights-To-San-Carlos-De-Bariloche.d6085464.Travel-Guide-Flights) - [Flights to Puerto Iguazú](https://expedia.co.uk/Cheap-Flights-To-Puerto-Iguazu.d6126331.Travel-Guide-Flights) - [Flights to Mendoza](https://expedia.co.uk/Cheap-Flights-To-Mendoza.d2255.Travel-Guide-Flights) - [Flights to Salta](https://expedia.co.uk/Cheap-Flights-To-Salta.d3199.Travel-Guide-Flights) - [Flights to Cordoba](https://expedia.co.uk/Cheap-Flights-To-Cordoba.d6054205.Travel-Guide-Flights) - [Flights to El Chalten](https://expedia.co.uk/Cheap-Flights-To-El-Chalten.d6055664.Travel-Guide-Flights) - [Flights to Rosario](https://expedia.co.uk/Cheap-Flights-To-Rosario.d3026.Travel-Guide-Flights) - [Flights to Mar del Plata](https://expedia.co.uk/Cheap-Flights-To-Mar-Del-Plata.d2252.Travel-Guide-Flights) - [Flights to Puerto Madryn](https://expedia.co.uk/Cheap-Flights-To-Puerto-Madryn.d500751.Travel-Guide-Flights) - [Flights to La Plata](https://expedia.co.uk/Cheap-Flights-To-La-Plata.d2119.Travel-Guide-Flights) - [Flights to Villa La Angostura](https://expedia.co.uk/Cheap-Flights-To-Villa-La-Angostura.d6035429.Travel-Guide-Flights) - [Flights to San Martín de los Andes](https://expedia.co.uk/Cheap-Flights-To-San-Martin-De-Los-Andes.d903.Travel-Guide-Flights) - [Flights to Tucuman](https://expedia.co.uk/Cheap-Flights-To-Tucuman.d6210982.Travel-Guide-Flights) - [Flights to San Salvador de Jujuy](https://expedia.co.uk/Cheap-Flights-To-San-Salvador-De-Jujuy.d6126344.Travel-Guide-Flights) ### Top Flight Destinations In World - [Flights to Thailand](https://expedia.co.uk/Destinations-In-Thailand.d178.Flight-Destinations) - [Flights to India](https://expedia.co.uk/Destinations-In-India.d80.Flight-Destinations) - [Flights to Australia](https://expedia.co.uk/Destinations-In-Australia.d10.Flight-Destinations) - [Flights to Japan](https://expedia.co.uk/Destinations-In-Japan.d89.Flight-Destinations) - [Flights to Türkiye](https://expedia.co.uk/Destinations-In-Turkiye.d183.Flight-Destinations) - [Flights to United States of America](https://expedia.co.uk/Destinations-In-United-States-Of-America.d201.Flight-Destinations) - [Flights to Canada](https://expedia.co.uk/Destinations-In-Canada.d31.Flight-Destinations) - [Flights to New Zealand](https://expedia.co.uk/Destinations-In-New-Zealand.d133.Flight-Destinations) - [Flights to Spain](https://expedia.co.uk/Destinations-In-Spain.d166.Flight-Destinations) - [Flights to Philippines](https://expedia.co.uk/Destinations-In-Philippines.d145.Flight-Destinations) - [Flights to Portugal](https://expedia.co.uk/Destinations-In-Portugal.d147.Flight-Destinations) - [Flights to South Africa](https://expedia.co.uk/Destinations-In-South-Africa.d165.Flight-Destinations) - [Flights to Italy](https://expedia.co.uk/Destinations-In-Italy.d86.Flight-Destinations) - [Flights to Vietnam](https://expedia.co.uk/Destinations-In-Vietnam.d194.Flight-Destinations) - [Flights to Egypt](https://expedia.co.uk/Destinations-In-Egypt.d52.Flight-Destinations) - [Flights to Greece](https://expedia.co.uk/Destinations-In-Greece.d67.Flight-Destinations) - [Flights to Germany](https://expedia.co.uk/Destinations-In-Germany.d64.Flight-Destinations) - [Flights to Ireland](https://expedia.co.uk/Destinations-In-Ireland.d84.Flight-Destinations) - [Flights to Morocco](https://expedia.co.uk/Destinations-In-Morocco.d122.Flight-Destinations) - [Flights to Russia](https://expedia.co.uk/Destinations-In-Russia.d153.Flight-Destinations) ### Related Airlines - [Amber Air](https://expedia.co.uk/Amber-Air-Flights.c0A.Travel-Guide-Airlines) - [BlueAir](https://expedia.co.uk/BlueAir-Flights.c0B.Travel-Guide-Airlines) - [Catovair](https://expedia.co.uk/Cobra-Aviation-Flights.c0C.Travel-Guide-Airlines) - [Darwin Airline SA Lugano](https://expedia.co.uk/Darwin-Airline-SA-Lugano-Flights.c0D.Travel-Guide-Airlines) - [Evergreen International](https://expedia.co.uk/Evergreen-International-Flights.c0E.Travel-Guide-Airlines) - [Ghadames Air Transport](https://expedia.co.uk/Ghadames-Air-Transport-Flights.c0G.Travel-Guide-Airlines) - [Aircompany Kokshetau](https://expedia.co.uk/AirCompany-Kokshetau-Flights.c0K.Travel-Guide-Airlines) - [Vietnam Air Service Co.](https://expedia.co.uk/Vietnam-Air-Service-Co-Flights.c0V.Travel-Guide-Airlines) - [West Caribbean Costa Rica](https://expedia.co.uk/West-Caribbean-Costa-Rica-Flights.c0W.Travel-Guide-Airlines) - [Olympus Airways](https://expedia.co.uk/Olympus-Airways-Flights.c11.Travel-Guide-Airlines) - [SkyService](https://expedia.co.uk/SkyService-Flights.c1S.Travel-Guide-Airlines) - [Bulgarian Air Charter](https://expedia.co.uk/Bulgarian-Air-Charter-Flights.c1T.Travel-Guide-Airlines) - [Branson Air Express](https://expedia.co.uk/Branson-Air-Express-Flights.c1X.Travel-Guide-Airlines) - [Deutsche Bahn](https://expedia.co.uk/Deutsche-Bahn-Flights.c2A.Travel-Guide-Airlines) - [Albawings](https://expedia.co.uk/Albawings-Flights.c2B.Travel-Guide-Airlines) - [S.N.C.F. French Rail](https://expedia.co.uk/SNCF-French-Rail-Flights.c2C.Travel-Guide-Airlines) \*Available to Expedia members. ![](https://a.travel-assets.com/mad-service/footer/bnaBanners/BEX_Footer.jpg) ## Go further with the Expedia app Save on select hotels when you book in the app. Our app deals help you to save on trips so you can travel more and manage it all on the go. Scan the QR code with your device camera and download our app ![QR code to download the app](data:image/png;base64,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)