Title: Cheap Flights to La Mesa - Expedia.co.uk

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# £242 Cheap Flights to La Mesa

[View £242 flight on Wed, 1 Apr 2026](https://expedia.co.uk/Flights-Search?trip=oneway&leg1=from:GCM,to:PTY,departure:01/04/2026TANYT&passengers=children:0,adults:1,seniors:0,infantinlap:N&mode=search&options=sortby:price&paandi=true&flp=mdl:flights-flex-module,price:241.20&airProductToken=AQpkCjAIwYIBEgQxODE1GMZgIIwCKJ2XiQMwh5iJAzhPQABYAWoETUFJTnIIT05VMk5NTTEKMAjBggESAzMxORiMAiDvxAEopqOJAzDkpIkDOFFAAVgBagRNQUlOcghRTk40TlRNMRIKCAEQARgBKgJBQRgBIgQIARABKAIoAygEMAs) 

[Hotels in La Mesa](https://expedia.co.uk/La-Mesa-Hotels.d553248635975862472.Travel-Guide-Hotels)[La Mesa Car Hire](https://expedia.co.uk/Compare-Cheap-Car-Hire-In-La-Mesa.d553248635975862472.Car-Hire-Guide)[La Mesa Holidays](https://expedia.co.uk/La-Mesa.d553248635975862472.Holidays-City-Breaks)

## Popular airlines

- ![](https://forever.travel-assets.com/flex/flexmanager/images/2024/09/23/landing_airline_sq_logo_AV.svg)  
Avianca  
[](https://www.expedia.co.uk/Flights-Search?leg1=from:CMH,to:La Mesa, Panamá Province, Panama,departure:09/03/2026TANYT&leg2=from:La Mesa, Panamá Province, Panama,to:CMH,departure:16/03/2026TANYT&trip=roundtrip&passengers=adults:1,children:0,infantinlap:N&mode=search&pageId=0&filters=[{"preferredAirlineFilterValue":{"carrierCode":"AV"}}])
- ![](https://forever.travel-assets.com/flex/flexmanager/images/2024/09/23/landing_airline_sq_logo_AA.svg)  
American Airlines  
[](https://www.expedia.co.uk/Flights-Search?leg1=from:CMH,to:La Mesa, Panamá Province, Panama,departure:09/03/2026TANYT&leg2=from:La Mesa, Panamá Province, Panama,to:CMH,departure:16/03/2026TANYT&trip=roundtrip&passengers=adults:1,children:0,infantinlap:N&mode=search&pageId=0&filters=[{"preferredAirlineFilterValue":{"carrierCode":"AA"}}])
- ![](https://forever.travel-assets.com/flex/flexmanager/images/2024/09/23/landing_airline_sq_logo_UA.svg)  
United  
[](https://www.expedia.co.uk/Flights-Search?leg1=from:CMH,to:La Mesa, Panamá Province, Panama,departure:09/03/2026TANYT&leg2=from:La Mesa, Panamá Province, Panama,to:CMH,departure:16/03/2026TANYT&trip=roundtrip&passengers=adults:1,children:0,infantinlap:N&mode=search&pageId=0&filters=[{"preferredAirlineFilterValue":{"carrierCode":"UA"}}])
- ![](https://forever.travel-assets.com/flex/flexmanager/images/2024/09/23/landing_airline_sq_logo_DL.svg)  
Delta  
[](https://www.expedia.co.uk/Flights-Search?leg1=from:CMH,to:La Mesa, Panamá Province, Panama,departure:09/03/2026TANYT&leg2=from:La Mesa, Panamá Province, Panama,to:CMH,departure:16/03/2026TANYT&trip=roundtrip&passengers=adults:1,children:0,infantinlap:N&mode=search&pageId=0&filters=[{"preferredAirlineFilterValue":{"carrierCode":"DL"}}])
- ![](https://forever.travel-assets.com/flex/flexmanager/images/2024/09/23/landing_airline_sq_logo_CM.svg)  
Copa  
[](https://www.expedia.co.uk/Flights-Search?leg1=from:CMH,to:La Mesa, Panamá Province, Panama,departure:09/03/2026TANYT&leg2=from:La Mesa, Panamá Province, Panama,to:CMH,departure:16/03/2026TANYT&trip=roundtrip&passengers=adults:1,children:0,infantinlap:N&mode=search&pageId=0&filters=[{"preferredAirlineFilterValue":{"carrierCode":"CM"}}])
- ![](https://forever.travel-assets.com/flex/flexmanager/images/2024/09/23/landing_airline_sq_logo_AM.svg)  
Aeromexico  
[](https://www.expedia.co.uk/Flights-Search?leg1=from:CMH,to:La Mesa, Panamá Province, Panama,departure:09/03/2026TANYT&leg2=from:La Mesa, Panamá Province, Panama,to:CMH,departure:16/03/2026TANYT&trip=roundtrip&passengers=adults:1,children:0,infantinlap:N&mode=search&pageId=0&filters=[{"preferredAirlineFilterValue":{"carrierCode":"AM"}}])
- ![](https://forever.travel-assets.com/flex/flexmanager/images/2024/09/23/landing_airline_sq_logo_KL.svg)  
KLM  
[](https://www.expedia.co.uk/Flights-Search?leg1=from:CMH,to:La Mesa, Panamá Province, Panama,departure:09/03/2026TANYT&leg2=from:La Mesa, Panamá Province, Panama,to:CMH,departure:16/03/2026TANYT&trip=roundtrip&passengers=adults:1,children:0,infantinlap:N&mode=search&pageId=0&filters=[{"preferredAirlineFilterValue":{"carrierCode":"KL"}}])

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## Cheap round-trip flights to La Mesa

Prices were available within the past 7 days and start at £242 for one-way flights and £317 for round trip, for the period specified. Be sure to select the 'Direct flights only' box above if you are looking for a non stop route. Prices and availability are subject to change. Additional terms apply.

All deals

One way

Return

![Cayman Airways](//images.trvl-media.com/media/content/expus/graphics/static_content/fusion/v0.1b/images/airlines/KX.gif)

Mon, 13 Apr - Thu, 16 Apr

GCM

Grand Cayman

PTY

Panama City

£317

Return

found 6 days ago

[](https://expedia.co.uk/Flights-Search?trip=roundtrip&leg1=from:GCM,to:PTY,departure:13/04/2026TANYT&leg2=from:PTY,to:GCM,departure:16/04/2026TANYT&passengers=children:0,adults:1,seniors:0,infantinlap:N&mode=search&options=sortby:price&paandi=true&flp=mdl:flights-flex-module,price:316.50&airProductToken=AQouCiwIy7ABEgM4NTIYxmAg78QBKP6figMw9qCKAzhWQABYAWoCRUxyBlY3QVBOUgouCiwIy7ABEgM4NTMY78QBIMZgKLDDigMwqMSKAzhWQABYAWoCRUxyBlY3QVBOUhIKCAEQARgBKgJLWBgBIgQIARABKAIoBCgGMAE)

![Copa](//images.trvl-media.com/media/content/expus/graphics/static_content/fusion/v0.1b/images/airlines/CM.gif)

Mon, 30 Mar - Fri, 3 Apr

KIN

Kingston

PTY

Panama City

£323

Return

found 4 days ago

[](https://expedia.co.uk/Flights-Search?trip=roundtrip&leg1=from:KIN,to:PTY,departure:30/03/2026TANYT&leg2=from:PTY,to:KIN,departure:03/04/2026TANYT&passengers=children:0,adults:1,seniors:0,infantinlap:N&mode=search&options=sortby:price&paandi=true&flp=mdl:flights-flex-module,price:322.60&airProductToken=AQoiCiAIw5oBEgM0MTcYimog78QBKI-EiQMwioWJAzhBQABYAQoiCiAIw5oBEgM0MTgY78QBIIpqKNmviQMwzLCJAzhBQABYARIKCAEQARgBKgJDTRgBIgQIARABKAQwAQ)

![American Airlines](//images.trvl-media.com/media/content/expus/graphics/static_content/fusion/v0.1b/images/airlines/AA.gif)

Tue, 18 Aug - Tue, 1 Sept

GCM

Grand Cayman

PTY

Panama City

£451

Return

found 6 days ago

[](https://expedia.co.uk/Flights-Search?trip=roundtrip&leg1=from:GCM,to:PTY,departure:18/08/2026TANYT&leg2=from:PTY,to:GCM,departure:01/09/2026TANYT&passengers=children:0,adults:1,seniors:0,infantinlap:N&mode=search&options=sortby:price&paandi=true&flp=mdl:flights-flex-module,price:450.60&airProductToken=AQpECiAIwYIBEgQxMzAxGMZgIIwCKIa1lQMw5bWVAzhPQABYAQogCMGCARIDOTU5GIwCIO_EASjlv5UDMKjBlQM4UUABWAEKRAohCMGCARIEMjE5MhjvxAEgjAIohNSWAzC91ZYDOFFAAFgBCh8IwYIBEgM5NTYYjAIgxmAotN2WAzCi3pYDOE9AAVgBEgoIARABGAEqAkFBGAEiBAgBEAEoCCgEMAE)

![KLM](//images.trvl-media.com/media/content/expus/graphics/static_content/fusion/v0.1b/images/airlines/KL.gif)

Mon, 13 Apr - Mon, 27 Apr

LHR

London

PTY

Panama City

£588

Return

found 3 days ago

[](https://expedia.co.uk/Flights-Search?trip=roundtrip&leg1=from:LHR,to:PTY,departure:13/04/2026TANYT&leg2=from:PTY,to:LHR,departure:27/04/2026TANYT&passengers=children:0,adults:1,seniors:0,infantinlap:N&mode=search&options=sortby:price&paandi=true&flp=mdl:flights-flex-module,price:587.35&airProductToken=AQppCjMIy5gBEgQxMDE0GOuJASCAkwEo56CKAzCyoYoDOExAAFgBagVMSUdIVHIIR0dMREk3TEkKMgjLmAESAzc1NxiAkwEg78QBKM-oigMw3q2KAzhHQAFYAWoFTElHSFRyCEdHTERJN0xJCmkKMgjLmAESAzc1OBjvxAEggJMBKPbAiwMw4sWLAzhHQABYAWoFTElHSFRyCEdHTERJN0xJCjMIy5gBEgQxMDEzGICTASDriQEok8iLAzDjyIsDOExAAVgBagVMSUdIVHIIR0dMREk3TEkSCggCEAEYAioCS0wYASIECAEQASgCKAMoBDAN)

![Air France](//images.trvl-media.com/media/content/expus/graphics/static_content/fusion/v0.1b/images/airlines/AF.gif)

Sun, 19 Apr - Sun, 26 Apr

MAN

Manchester

PTY

Panama City

£594

Return

found 13 hours ago

[](https://expedia.co.uk/Flights-Search?trip=roundtrip&leg1=from:MAN,to:PTY,departure:19/04/2026TANYT&leg2=from:PTY,to:MAN,departure:26/04/2026TANYT&passengers=children:0,adults:1,seniors:0,infantinlap:N&mode=search&options=sortby:price&paandi=true&flp=mdl:flights-flex-module,price:593.23&airProductToken=AQpmCjEIwYwBEgQxMjY5GIxoIOIwKILeigMw696KAzhMQABYAWoFTElHSFRyCEdHTERJN0xJCjEIwYwBEgM0OTAY4jAg78QBKJniigMwreeKAzhHQAFYAWoFTElHSFRyCEdHTERJN0xJCmYKMQjBjAESAzQ5MRjvxAEg4jAoj7eLAzD2u4sDOEdAAFgBagVMSUdIVHIIR0dMREk3TEkKMQjBjAESBDE2NjgY4jAgjGgovcSLAzCcxYsDOExAAVgBagVMSUdIVHIIR0dMREk3TEkSCggCEAEYAioCQUYYASIECAEQASgCKAMoBDAN)

## Find the cheapest month to fly from Columbus (CMH) to Panama City (PTY)

### October is typically the cheapest month to fly

From £273 - £812 per traveller.

![](https://forever.travel-assets.com/flex/flexmanager/images/2026/02/06/expedia-sale-2026-desktop-uk-fr-de.jpg?impolicy=fcrop&w=1400&h=600&q=mediumHigh)

## 

The Annual Holiday Sale

Members save up to 40% on hotels and holiday homes. Plan this year’s big trip and save.

[Book now](https://expedia.co.uk/cheap-deals?rfrr=FTG_SPRING_PROMO_)

## Book with confidence

# Expedia flights to La Mesa

Searching for cheap flights to La Mesa? No travel company presents more choices than Expedia if you're looking to compare flights to La Mesa. With more airlines, cheaper flights, fewer stops, and more departure and arrival times travellers should ensure they search on Expedia before any holiday to San Martín. Expedia provides the cheapest flights to many destinations in San Martín and you may find even greater savings if you combine your flight with a hotel stay in La Mesa.

Expedia is the largest online travel agency which means that Expedia have access to cheap flights. So make sure you check Expedia regularly for these bargain flights because the cheapest airline tickets sell out fast.

Expedia is not only free for everyone to use but it quick and easy to use. Find the lowest flight prices guaranteed and book directly through Expedia. Browse through hundreds of cheap flight offers to find the one that suits your budget by simply inputting your travel dates. Expedia will then find the cheapest flights to La Mesa for that period and let you choose your preferred time and airline. If you need additional assistance, Expedia Customer Service representatives are available from 8am - 10pm Monday to Friday, and 9am - 10pm at weekends. Our capable staff will be able to help you with any questions regarding your La Mesa flight, or other booking questions that may arise. When you book flights with Expedia you can rest assured that you have booked the best flight at the lowest price.

## Travel information

| Destination airport           | Tocumen Intl. |
| ----------------------------- | ------------- |
| Destination airport IATA code | PTY           |
| Destination city name         | Panama City   |
| Return price                  | £316          |

## Trending flights to La Mesa

Prices were available within the past 7 days and start at £242 for one-way flights and £317 for round trip, for the period specified. Be sure to select the 'Direct flights only' box above if you are looking for a non stop route. Prices and availability are subject to change. Additional terms apply.

All deals

One way

Return

![KLM](//images.trvl-media.com/media/content/expus/graphics/static_content/fusion/v0.1b/images/airlines/KL.gif)

Mon, 13 Apr - Mon, 27 Apr

LHR

London

PTY

Panama City

£588

Return

found 3 days ago

[](https://expedia.co.uk/Flights-Search?trip=roundtrip&leg1=from:LHR,to:PTY,departure:13/04/2026TANYT&leg2=from:PTY,to:LHR,departure:27/04/2026TANYT&passengers=children:0,adults:1,seniors:0,infantinlap:N&mode=search&options=sortby:price&paandi=true&flp=mdl:flights-flex-module,price:587.35&airProductToken=AQppCjMIy5gBEgQxMDE0GOuJASCAkwEo56CKAzCyoYoDOExAAFgBagVMSUdIVHIIR0dMREk3TEkKMgjLmAESAzc1NxiAkwEg78QBKM-oigMw3q2KAzhHQAFYAWoFTElHSFRyCEdHTERJN0xJCmkKMgjLmAESAzc1OBjvxAEggJMBKPbAiwMw4sWLAzhHQABYAWoFTElHSFRyCEdHTERJN0xJCjMIy5gBEgQxMDEzGICTASDriQEok8iLAzDjyIsDOExAAVgBagVMSUdIVHIIR0dMREk3TEkSCggCEAEYAioCS0wYASIECAEQASgCKAMoBDAN)

\*Available to Expedia members.