Antofagasta Region Holidays

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Your Antofagasta Region Holiday

Leave the travel planning up to us with an Antofagasta Region holiday package. With everything arranged before you jet off, all you need to do is relax and enjoy this destination's culture and charm. Your trip to Antofagasta Region wouldn't be complete without exploring some of its most well-known cities, starting with San Pedro de Atacama. A couple of the top attractions here include Piedra del Coyote Overlook and San Pedro Church. Antofagasta is another favourite city with Antofagasta Region travellers. Visitors to this exciting city enjoy Antofagasta Fish Market and Central Market. From the moment you book your Antofagasta Region holiday to when you get back home, Expedia has you covered every step of the way.

Top destinations in Antofagasta Region

FlightsFlightsHotelsHotels

San Pedro de Atacama

San Pedro de Atacama

Antofagasta (region)

Taste fresh seafood from the Pacific Coast and explore the salt flats and arid lava flows of the highlands plateau in this large region in Chile’s north.

With vast arid landscapes that plunge into the cliff-edged Pacific Ocean, Antofagasta is the second-largest region in Chile and is crowned by the city of the same name. The dramatic region is characterized by the altiplano highland plateaus, but is fringed to the west by a string of charming seaside villages and fishing wharves. 

Explore the city of Antofagasta to relax on the waterfront and sample fresh local seafood, or check out inland Calama to experience the desert landscapes that transform into the unparalleled Atacama.

Begin your travels in this vast region with a visit to the city of Antofagasta. Stroll along the city’s charming waterfront and watch fishing boats coming and going from the wharf. At the fishing harbour, you can watch sea lions, pelicans and seabirds being fed fish from the day’s catch. Visit a local fishmonger or a seafood restaurant to try some of the catch for yourself.

Visit geological formations at La Portada Natural Monument, which is an impressive coastal cliff comprised of volcanic rocks and fossils. Explore the vast beaches of Playa Grande when you check out the nearby town of Mejillones.

Explore inland to the town of Calama to reach the gateway to Antofagasta’s remote wilderness. You can visit a vast open-cut mine, Chuquicamata, in this town. If you are up to the challenge, rent a four-wheel drive and explore the moonscape scenery of the surrounding salt flats. You can also reach Chiu-Chiu and its ruins, churches and lagoons.

Continue northeast to reach the eerie plumes of the Geyser of Tatio. Calama is an interesting stopover for travellers heading toward San Pedro de Atacama and the Atacama Desert.

Reach Antofagasta via the airports in Calama or the city of Antofagasta. There are several buses that connect the towns and smaller communities in Antofagasta and its neighbour, Atacama. In the region’s towns, you can hire taxis, catch local buses or explore on foot. 

With its fascinating desert landscapes and scenic coastal towns, Antofagasta is an ideal destination on your adventures in Northern Chile.

Antofagasta Region Essential Information

Language
Spanish
Currency
Chilean pesos
Local Welcome
¡Hola!
Local Goodbye
Adiós
Closest Airport
Cerro Moreno Intl. Airport (ANF)
Population
309,800
Top Sights
Valley of the Moon, Arco Iris Valley and Piedra del Coyote Overlook

Top hotels in Antofagasta Region

Diego de Almagro San Pedro de Atacama

Diego de Almagro San Pedro de Atacama

3 out of 5
Toconao 460 San Pedro de Atacama Antofagasta
The price is £78 per night from 6 May to 7 May
£78
6 May - 7 May
8.2/10 Very Good! (378 reviews)
Nice welcome

Reviewed on 21 Apr 2026

Diego de Almagro San Pedro de Atacama
Hotel La Casa de Don Tomas

Hotel La Casa de Don Tomas

3 out of 5
Calle Tocopilla Sitio 18 San Pedro de Atacama
Fully refundableReserve now, pay when you stay
The price is £155 per night from 8 May to 9 May
£155
8 May - 9 May
9.2/10 Wonderful! (408 reviews)
todo muy bien

Reviewed on 10 Apr 2026

Hotel La Casa de Don Tomas
Terrado Suites Antofagasta

Terrado Suites Antofagasta

4 out of 5
Baquedano 015 Antofagasta Antofagasta
Fully refundableReserve now, pay when you stay
The price is £53 per night from 15 May to 16 May
£53
15 May - 16 May
8.4/10 Very Good! (317 reviews)
Good breakfast, welcoming and helpful staff, nice restaurant. Great views from the room.

Reviewed on 10 Apr 2026

Terrado Suites Antofagasta
See all 315 properties in Antofagasta Region
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Frequently asked questions

How much does an Antofagasta Region travel package cost?
Perhaps less than you imagined — from a low , as a matter of fact! By bundling flights, hotels and car rentals into a custom-made package, your Antofagasta Region escape is just clicks away.
If I'm not able to travel, can I cancel my Antofagasta Region travel package?
We totally get it — life can throw you the odd curveball. If you've locked in an Antofagasta Region travel package and have to cancel or change it, we're here to help. We recommend having a look at our Customer Service Portal first for information. But generally, if you've taken out your package in the last 24 hours, you may be able to cancel and rebook at no cost. If it's been more than 24 hours, your airline, hotel or car rental company may impose a fee.
How do I get a cheap travel package to Antofagasta Region?
If you love scoring a bargain, bundle your bookings into an Antofagasta Region travel package. Whether you're chasing hotels, flights, tours or rental cars, you can book everything in one place. You'll have loads of choice at your fingertips too. Expedia has more than 550 airlines and 1,000,000 hotel options throughout the world to pick from. Fly with who you want, stay where you like and save your hard-earned money — now that's the ideal escape!
Does Expedia offer Book Now, Pay Later Antofagasta Region holidays?
Yes. Expedia has joined forces with online lender Klarna to help you easily pay for your trip in manageable instalments. Simply pick the payment plan that suits you best during checkout and take away the stress of budgeting for your next trip. Don't forget to bundle your flights, hotel and car hire with Expedia to get the biggest bang for your holiday buck. Take a look at our flexible payment options below:

  • Pay monthly holidays: Klarna offers manageable monthly payment plans that fit all budgets, so you can book that well-earned holiday sooner.
  • Pay in instalments holidays: With this Book Now, Pay Later option, Klarna makes it easy to pay off your holiday over multiple transactions.
  • Low deposit holidays: Hitting the "book now" button is easier with this plan. Simply put down a small deposit on your escape and then start packing your bags.

What are the top hotels in Antofagasta Region?
Hotel Antofagasta and Terrado Suites Antofagasta know how to make their guests feel welcome in Antofagasta. If your travel plans also include San Pedro de Atacama, take a look at Terrantai Lodge Hotel and Altiplánico San Pedro de Atacama. Both are very popular with travellers.
How far in advance should I book my Antofagasta Region holiday?
While not all air carriers release ticket prices early, it's usually possible to start comparing international flights on Expedia up to a year in advance. This is when you can score some fantastic bargains. If you're booking last minute, there's a chance you could get lucky. Discounted prices occasionally appear just weeks before departure.
What does an Expedia Antofagasta Region travel package include?
Expedia has everything you need to book your Antofagasta Region getaway, but how you structure your package is entirely up to you. Select from any combination of hotels, rental cars and flights. In search of some tours or activities to keep you on the go? Once you've made your booking, you can add them on too. Whatever your style, there's a deal to match your needs.
What should I know before booking an Antofagasta Region travel package?
You'll save big with an Expedia travel package. Bundle your flights, rental cars and hotels and score fabulous discounts. Hotels aren't your only option, though. Book with us and select from beachfront villas, rural cottages and just about everything in between!
Can I choose my airline with an Antofagasta Region Expedia travel package?
Yes — and it's easy too. Expedia has access to more than 550 partner airlines globally. Our packages give you the flexibility to take your pick of available flights, hotels and activities that fit your needs.

* Savings based on package bookings compared to the price of the same components booked separately. Savings not available on all packages. Flight-inclusive packages are ATOL protected.