The best area to stay in Agua Prieta is near the main commercial areas, particularly around Avenida 6 and Calle Internacional, for convenience and access to amenities.
This central part of Agua Prieta is where you'll find most of the town's hotels, restaurants, and shops. It's a busy area during the day, making it easy to find everything you might need. The border crossing is also very close by, which is useful for those travelling between Mexico and the USA.
For solo travellers or those on a business trip, staying in this central area is very practical. You'll be close to local businesses and have easy access to dining options without needing to travel far.