The hotel itself is situated 1 minutes walk to Market Street where most of the shopping is located the convenience itself is a plus. The staff is really fantastic they give guest the feel of home especially for a first time guest of the city their service in my opinion surpass the 5 stars hotel.
As to safety the area in general there are a lot of homeless people asking for money and cigarette you just have to be polite and reject them no need to be mean or aggressive towards them mind you there is also 5 star hotel in the same area but the hotel staff really do their part by not letting non guest to enter the hotel which includes the use of their toilets. I would strongly advice family visitors do not let their children roam about in the nights.
If you need a cab let the front desk know so that they get their regular/trusted cab drivers to service you but as most of the things are nearby the only time you may need the cab is to the airport.
My hsuband and I stayed here, while he had a class, and I did my Xmas shopping ! Great location....about a 5 min walk to Union Square, and all the stores around that area. I loved how the hotel has Jaspers restaurant attached to it......they had the most delish stuffed french toast, I have ever had !! Would stay here again....:)
The Mark Twain Hotel never pretends to be other than it is. It is a hotel built long before Big Macs and Starbucks. The windows open (no air conditioning) and you get a nice breeze. Newly updated (paint, carpet, etc.) the rooms are scrupulously clean! If you want a little more space, choose one of the larger rooms. Yes, there is street noise in some of the rooms, but you are in a city, after all.
The staff was helpful and breakfast items were plentiful (I grabbed a coffee, banana, and yogurt). Food in the immediate neighborhood was good. There is a cafe next door that had a line down the street during the breakfast rush (got breakfast later, around 11:30, and it was quick, and excellent.
There is a taxi stand across the street, and transit is close. I didn't rent a car as it is expensive to house them, and you don't really need one in the city (parking in S.F. can be a challenge.)
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