This information about transportation options in Guaymas might help your romantic trip get off to a smooth start: To get to Guaymas, book a flight to Guaymas, Sonora (GYM-General Jose Maria Yanez Intl.), which is the closest major airport, located 3.6 mi (5.9 km) from the city centre. If you’d like to venture out around the area, you may want a rental car for your journey.